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681 related items for PubMed ID: 11358816

  • 1. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
    Brognard J, Clark AS, Ni Y, Dennis PA.
    Cancer Res; 2001 May 15; 61(10):3986-97. PubMed ID: 11358816
    [Abstract] [Full Text] [Related]

  • 2. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
    Kandasamy K, Srivastava RK.
    Cancer Res; 2002 Sep 01; 62(17):4929-37. PubMed ID: 12208743
    [Abstract] [Full Text] [Related]

  • 3. Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
    Tanno S, Yanagawa N, Habiro A, Koizumi K, Nakano Y, Osanai M, Mizukami Y, Okumura T, Testa JR, Kohgo Y.
    Cancer Res; 2004 May 15; 64(10):3486-90. PubMed ID: 15150102
    [Abstract] [Full Text] [Related]

  • 4. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
    Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    J Biol Chem; 2001 Oct 19; 276(42):38361-9. PubMed ID: 11461904
    [Abstract] [Full Text] [Related]

  • 5. Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway.
    Nguyen DM, Chen GA, Reddy R, Tsai W, Schrump WD, Cole G, Schrump DS.
    J Thorac Cardiovasc Surg; 2004 Feb 19; 127(2):365-75. PubMed ID: 14762343
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo.
    Denlinger CE, Rundall BK, Jones DR.
    J Thorac Cardiovasc Surg; 2005 Nov 19; 130(5):1422-9. PubMed ID: 16256798
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells.
    Chen YL, Law PY, Loh HH.
    Cancer Res; 2004 Dec 01; 64(23):8723-30. PubMed ID: 15574783
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.
    Uddin S, Hussain AR, Al-Hussein KA, Manogaran PS, Wickrema A, Gutierrez MI, Bhatia KG.
    Clin Cancer Res; 2005 Apr 15; 11(8):3102-8. PubMed ID: 15837766
    [Abstract] [Full Text] [Related]

  • 9. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
    Clark AS, West K, Streicher S, Dennis PA.
    Mol Cancer Ther; 2002 Jul 15; 1(9):707-17. PubMed ID: 12479367
    [Abstract] [Full Text] [Related]

  • 10. Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
    Brognard J, Dennis PA.
    Cell Death Differ; 2002 Sep 15; 9(9):893-904. PubMed ID: 12181740
    [Abstract] [Full Text] [Related]

  • 11. The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.
    Semba S, Itoh N, Ito M, Harada M, Yamakawa M.
    Clin Cancer Res; 2002 Jun 15; 8(6):1957-63. PubMed ID: 12060641
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
    Tsurutani J, West KA, Sayyah J, Gills JJ, Dennis PA.
    Cancer Res; 2005 Sep 15; 65(18):8423-32. PubMed ID: 16166321
    [Abstract] [Full Text] [Related]

  • 13. Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons.
    Virdee K, Xue L, Hemmings BA, Goemans C, Heumann R, Tolkovsky AM.
    Brain Res; 1999 Aug 07; 837(1-2):127-42. PubMed ID: 10433995
    [Abstract] [Full Text] [Related]

  • 14. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
    Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L, Ruggeri A, Conte R, Cocco L.
    Leukemia; 2003 Sep 07; 17(9):1794-805. PubMed ID: 12970779
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy.
    Krystal GW, Sulanke G, Litz J.
    Mol Cancer Ther; 2002 Sep 07; 1(11):913-22. PubMed ID: 12481412
    [Abstract] [Full Text] [Related]

  • 16. Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway.
    Birkenkamp KU, Geugien M, Schepers H, Westra J, Lemmink HH, Vellenga E.
    Leukemia; 2004 Jan 07; 18(1):103-12. PubMed ID: 14574326
    [Abstract] [Full Text] [Related]

  • 17. The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.
    Moore SM, Rintoul RC, Walker TR, Chilvers ER, Haslett C, Sethi T.
    Cancer Res; 1998 Nov 15; 58(22):5239-47. PubMed ID: 9823338
    [Abstract] [Full Text] [Related]

  • 18. Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells.
    Lee HY, Moon H, Chun KH, Chang YS, Hassan K, Ji L, Lotan R, Khuri FR, Hong WK.
    J Natl Cancer Inst; 2004 Oct 20; 96(20):1536-48. PubMed ID: 15494604
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.
    Gottschalk AR, Doan A, Nakamura JL, Haas-Kogan DA, Stokoe D.
    Int J Radiat Oncol Biol Phys; 2005 Mar 15; 61(4):1183-8. PubMed ID: 15752900
    [Abstract] [Full Text] [Related]

  • 20. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells.
    Söderlund K, Pérez-Tenorio G, Stål O.
    Int J Oncol; 2005 Jan 15; 26(1):25-32. PubMed ID: 15586221
    [Abstract] [Full Text] [Related]

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