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Journal Abstract Search

153 related items for PubMed ID: 11511170

  • 1. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug; 14(8):965-74. PubMed ID: 11511170
    [Abstract] [Full Text] [Related]

  • 2. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
    Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.
    Chem Res Toxicol; 2001 Jan; 14(1):62-70. PubMed ID: 11170509
    [Abstract] [Full Text] [Related]

  • 3. Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
    He K, Woolf TF, Kindt EK, Fielder AE, Talaat RE.
    Biochem Pharmacol; 2001 Jul 15; 62(2):191-8. PubMed ID: 11389877
    [Abstract] [Full Text] [Related]

  • 4. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

  • 5. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
    He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.
    Drug Metab Dispos; 2004 Jun 10; 32(6):639-46. PubMed ID: 15155556
    [Abstract] [Full Text] [Related]

  • 6. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.
    Sahi J, Hamilton G, Sinz M, Barros S, Huang SM, Lesko LJ, LeCluyse EL.
    Xenobiotica; 2000 Mar 10; 30(3):273-84. PubMed ID: 10752642
    [Abstract] [Full Text] [Related]

  • 7. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
    Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL.
    J Pharmacol Exp Ther; 2010 Jan 10; 332(1):26-34. PubMed ID: 19801447
    [Abstract] [Full Text] [Related]

  • 8. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes.
    Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T.
    Drug Metab Dispos; 1999 Nov 10; 27(11):1260-6. PubMed ID: 10534310
    [Abstract] [Full Text] [Related]

  • 9. Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
    Meechan AJ, Henderson C, Bates CD, Grant MH, Tettey JN.
    J Pharm Pharmacol; 2006 Oct 10; 58(10):1359-65. PubMed ID: 17034659
    [Abstract] [Full Text] [Related]

  • 10. Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping.
    Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K.
    Drug Metab Lett; 2008 Aug 10; 2(3):184-9. PubMed ID: 19356091
    [Abstract] [Full Text] [Related]

  • 11. Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry.
    Baillie TA, Kassahun K.
    Adv Exp Med Biol; 2001 Aug 10; 500():45-51. PubMed ID: 11764978
    [No Abstract] [Full Text] [Related]

  • 12. Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
    Masubuchi Y.
    Drug Metab Pharmacokinet; 2006 Oct 10; 21(5):347-56. PubMed ID: 17072088
    [Abstract] [Full Text] [Related]

  • 13. Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
    Li J, Kaneko T, Wang Y, Qin LQ, Wang PY, Sato A.
    Toxicology; 2002 Jul 01; 176(1-2):91-100. PubMed ID: 12062933
    [Abstract] [Full Text] [Related]

  • 14. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
    Saha S, New LS, Ho HK, Chui WK, Chan EC.
    Toxicol Lett; 2010 Feb 01; 192(2):141-9. PubMed ID: 19854250
    [Abstract] [Full Text] [Related]

  • 15. Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
    He K, Talaat RE, Woolf TF.
    Drug Metab Dispos; 2004 Apr 01; 32(4):442-6. PubMed ID: 15039298
    [Abstract] [Full Text] [Related]

  • 16. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
    Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW.
    Drug Metab Dispos; 2003 Apr 01; 31(4):439-46. PubMed ID: 12642470
    [Abstract] [Full Text] [Related]

  • 17. Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.
    Yamamoto Y, Yamazaki H, Ikeda T, Watanabe T, Iwabuchi H, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2002 Feb 01; 30(2):155-60. PubMed ID: 11792684
    [Abstract] [Full Text] [Related]

  • 18. Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes.
    Ramachandran V, Kostrubsky VE, Komoroski BJ, Zhang S, Dorko K, Esplen JE, Strom SC, Venkataramanan R.
    Drug Metab Dispos; 1999 Oct 01; 27(10):1194-9. PubMed ID: 10497147
    [Abstract] [Full Text] [Related]

  • 19. The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats.
    Kostrubsky VE, Vore M, Kindt E, Burliegh J, Rogers K, Peter G, Altrogge D, Sinz MW.
    Drug Metab Dispos; 2001 Dec 01; 29(12):1561-6. PubMed ID: 11717175
    [Abstract] [Full Text] [Related]

  • 20. Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.
    Yang K, Brouwer KL.
    Drug Metab Dispos; 2014 Jul 01; 42(7):1219-26. PubMed ID: 24799397
    [Abstract] [Full Text] [Related]

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