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Journal Abstract Search

130 related items for PubMed ID: 11527724

  • 1. Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
    Dener JM, Wang VR, Rice KD, Gangloff AR, Kuo EY, Newcomb WS, Putnam D, Wong M.
    Bioorg Med Chem Lett; 2001 Sep 03; 11(17):2325-30. PubMed ID: 11527724
    [Abstract] [Full Text] [Related]

  • 2. Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors.
    Rice KD, Gangloff AR, Kuo EY, Dener JM, Wang VR, Lum R, Newcomb WS, Havel C, Putnam D, Cregar L, Wong M, Warne RL.
    Bioorg Med Chem Lett; 2000 Oct 16; 10(20):2357-60. PubMed ID: 11055355
    [Abstract] [Full Text] [Related]

  • 3. Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.
    Dener JM, Rice KD, Newcomb WS, Wang VR, Young WB, Gangloff AR, Kuo EY, Cregar L, Putnam D, Wong M.
    Bioorg Med Chem Lett; 2001 Jul 09; 11(13):1629-33. PubMed ID: 11425524
    [Abstract] [Full Text] [Related]

  • 4. Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
    Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M.
    J Pharmacol Sci; 2003 Aug 09; 92(4):420-3. PubMed ID: 12939527
    [Abstract] [Full Text] [Related]

  • 5. Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors.
    Ono S, Kuwahara S, Takeuchi M, Sakashita H, Naito Y, Kondo T.
    Bioorg Med Chem Lett; 1999 Dec 06; 9(23):3285-90. PubMed ID: 10612586
    [Abstract] [Full Text] [Related]

  • 6. Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
    Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2859-72. PubMed ID: 15781396
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of human mast cell tryptase by benzamidine derivatives.
    Stürzebecher J, Prasa D, Sommerhoff CP.
    Biol Chem Hoppe Seyler; 1992 Oct 15; 373(10):1025-30. PubMed ID: 1418674
    [Abstract] [Full Text] [Related]

  • 8. Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.
    Rice KD, Wang VR, Gangloff AR, Kuo EY, Dener JM, Newcomb WS, Young WB, Putnam D, Cregar L, Wong M, Simpson PJ.
    Bioorg Med Chem Lett; 2000 Oct 16; 10(20):2361-6. PubMed ID: 11055356
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of tryptase for the treatment of mast cell-mediated diseases.
    Rice KD, Tanaka RD, Katz BA, Numerof RP, Moore WR.
    Curr Pharm Des; 1998 Oct 16; 4(5):381-96. PubMed ID: 10197050
    [Abstract] [Full Text] [Related]

  • 10. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.
    Selwood T, Elrod KC, Schechter NM.
    Biol Chem; 2003 Dec 16; 384(12):1605-11. PubMed ID: 14719803
    [Abstract] [Full Text] [Related]

  • 11. Combinatorial approaches towards the discovery of new tryptase inhibitors.
    del Fresno M, Fernández-Forner D, Miralpeix M, Segarra V, Ryder H, Royo M, Albericio F.
    Bioorg Med Chem Lett; 2005 Mar 15; 15(6):1659-64. PubMed ID: 15745817
    [Abstract] [Full Text] [Related]

  • 12. Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases.
    Caughey GH, Raymond WW, Bacci E, Lombardy RJ, Tidwell RR.
    J Pharmacol Exp Ther; 1993 Feb 15; 264(2):676-82. PubMed ID: 8437115
    [Abstract] [Full Text] [Related]

  • 13. Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.
    Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M.
    Bioorg Med Chem Lett; 2004 Oct 04; 14(19):4819-23. PubMed ID: 15341931
    [Abstract] [Full Text] [Related]

  • 14. Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug.
    Erba F, Fiorucci L, Pascarella S, Menegatti E, Ascenzi P, Ascoli F.
    Biochem Pharmacol; 2001 Feb 01; 61(3):271-6. PubMed ID: 11172730
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of potent and highly selective inhibitors of human tryptase.
    Slusarchyk WA, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Sutton JC, Treuner U, Zahler R, Zhao G, Bisacchi GS.
    Bioorg Med Chem Lett; 2002 Nov 04; 12(21):3235-8. PubMed ID: 12372541
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
    Jackson DS, Fraser SA, Ni LM, Kam CM, Winkler U, Johnson DA, Froelich CJ, Hudig D, Powers JC.
    J Med Chem; 1998 Jun 18; 41(13):2289-301. PubMed ID: 9632362
    [Abstract] [Full Text] [Related]

  • 17. Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.
    Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R.
    Bioorg Med Chem Lett; 2003 Apr 17; 13(8):1495-8. PubMed ID: 12668020
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
    Bisacchi GS, Slusarchyk WA, Bolton SA, Hartl KS, Jacobs G, Mathur A, Meng W, Ogletree ML, Pi Z, Sutton JC, Treuner U, Zahler R, Zhao G, Seiler SM.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2227-31. PubMed ID: 15081014
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors.
    Miyazaki Y, Kato Y, Manabe T, Shimada H, Mizuno M, Egusa T, Ohkouchi M, Shiromizu I, Matsusue T, Yamamoto I.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2986-90. PubMed ID: 16540315
    [Abstract] [Full Text] [Related]

  • 20. Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
    Sutton JC, Bolton SA, Davis ME, Hartl KS, Jacobson B, Mathur A, Ogletree ML, Slusarchyk WA, Zahler R, Seiler SM, Bisacchi GS.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2233-9. PubMed ID: 15081015
    [Abstract] [Full Text] [Related]

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