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541 related items for PubMed ID: 11535123

  • 1. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
    Sandy JD, Verscharen C.
    Biochem J; 2001 Sep 15; 358(Pt 3):615-26. PubMed ID: 11535123
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  • 2. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
    Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS.
    Osteoarthritis Cartilage; 2006 Feb 15; 14(2):101-13. PubMed ID: 16188468
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  • 5. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
    Lohmander LS, Neame PJ, Sandy JD.
    Arthritis Rheum; 1993 Sep 15; 36(9):1214-22. PubMed ID: 8216415
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  • 6. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
    Chockalingam PS, Zeng W, Morris EA, Flannery CR.
    Arthritis Rheum; 2004 Sep 15; 50(9):2839-48. PubMed ID: 15457452
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  • 10. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD, Pratta MA, Fox JW, Arner EC.
    J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721
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  • 11. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
    Fosang AJ, Last K, Maciewicz RA.
    J Clin Invest; 1996 Nov 15; 98(10):2292-9. PubMed ID: 8941646
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  • 12. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis.
    Lohmander LS, Saxne T, Heinegård DK.
    Ann Rheum Dis; 1994 Jan 15; 53(1):8-13. PubMed ID: 8311563
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  • 14. Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice.
    Chambers MG, Cox L, Chong L, Suri N, Cover P, Bayliss MT, Mason RM.
    Arthritis Rheum; 2001 Jun 15; 44(6):1455-65. PubMed ID: 11407708
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  • 15. The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
    Sandy JD, Thompson V, Doege K, Verscharen C.
    Biochem J; 2000 Oct 01; 351(Pt 1):161-6. PubMed ID: 10998358
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  • 18. Mechanism of catabolism of aggrecan by articular cartilage.
    Ilic MZ, Handley CJ, Robinson HC, Mok MT.
    Arch Biochem Biophys; 1992 Apr 01; 294(1):115-22. PubMed ID: 1550337
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