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Journal Abstract Search

82 related items for PubMed ID: 11554544

  • 1. Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
    Naimi E, Duan W, Wiebe LI, Knaus EE.
    Nucleosides Nucleotides Nucleic Acids; 2001 Aug; 20(8):1533-53. PubMed ID: 11554544
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  • 3. Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related alpha-anomers, and their evaluation as antiviral and anticancer agents.
    Wang ZX, Duan W, Wiebe LI, Balzarini J, De Clercq E, Knaus EE.
    Nucleosides Nucleotides Nucleic Acids; 2001 Aug; 20(1-2):11-40. PubMed ID: 11303557
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  • 4. Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]- derivatives of 5-substituted-2,4-difluorobenzene: unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents.
    Wang ZX, Duan W, Wiebe LI, De Clercq E, Balzarini J, Knaus EE.
    Nucleosides Nucleotides Nucleic Acids; 2000 Sep; 19(9):1397-411. PubMed ID: 11092311
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  • 6. Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
    Moharram S, Zhou A, Wiebe LI, Knaus EE.
    J Med Chem; 2004 Mar 25; 47(7):1840-6. PubMed ID: 15027876
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
    Morin KW, Atrazheva ED, Knaus EE, Wiebe LI.
    J Med Chem; 1997 Jul 04; 40(14):2184-90. PubMed ID: 9216837
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  • 8. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
    Balzarini J, Bohman C, Walker RT, de Clercq E.
    Mol Pharmacol; 1994 Jun 04; 45(6):1253-8. PubMed ID: 8022417
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  • 9. Synthesis and evaluation of novel thymidine analogs as antitumor and antiviral agents.
    Chen X, Bastow K, Goz B, Kucera LS, Morris-Natschke SL, Ishaq KS.
    J Med Chem; 1996 Aug 16; 39(17):3412-7. PubMed ID: 8765526
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  • 10. 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
    Cristofoli WA, Wiebe LI, De Clercq E, Andrei G, Snoeck R, Balzarini J, Knaus EE.
    J Med Chem; 2007 Jun 14; 50(12):2851-7. PubMed ID: 17518459
    [Abstract] [Full Text] [Related]

  • 11. Cyclosaligenyl pronucleotides of 5-iodo and 5-trifluoromethyl-1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluorobenzene mimics of thymidine: synthesis and evaluation of this pronucleotide monophosphate delivery system for compounds with potential anticancer activity.
    Sun WY, Zhou A, Wiebe LI, Knaus EE.
    Nucleosides Nucleotides Nucleic Acids; 2003 Dec 14; 22(12):2121-32. PubMed ID: 14714761
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides.
    Meade EA, Wotring LL, Drach JC, Townsend LB.
    J Med Chem; 1997 Feb 28; 40(5):794-801. PubMed ID: 9057866
    [Abstract] [Full Text] [Related]

  • 13. 5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
    Germann C, Shields AF, Grierson JR, Morr I, Haberkorn U.
    J Nucl Med; 1998 Aug 28; 39(8):1418-23. PubMed ID: 9708520
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  • 14. Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.
    Migawa MT, Drach JC, Townsend LB.
    J Med Chem; 2005 Jun 02; 48(11):3840-51. PubMed ID: 15916436
    [Abstract] [Full Text] [Related]

  • 15. (E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
    Hamel W, Zirkel D, Mehdorn HM, Westphal M, Israel MA.
    Cancer Gene Ther; 2001 May 02; 8(5):388-96. PubMed ID: 11477459
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  • 16. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
    Hernandez AI, Familiar O, Negri A, Rodríguez-Barrios F, Gago F, Karlsson A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ.
    J Med Chem; 2006 Dec 28; 49(26):7766-73. PubMed ID: 17181158
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  • 17. Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity.
    Renau TE, Wotring LL, Drach JC, Townsend LB.
    J Med Chem; 1996 Feb 16; 39(4):873-80. PubMed ID: 8632411
    [Abstract] [Full Text] [Related]

  • 18. 6-Azathymidine-4'-thionucleosides: synthesis and antiviral evaluation.
    Jasamai M, Balzarini J, Simons C.
    J Enzyme Inhib Med Chem; 2008 Feb 16; 23(1):56-61. PubMed ID: 18341254
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  • 19. 6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
    Maslen HL, Hughes D, Hursthouse M, De Clercq E, Balzarini J, Simons C.
    J Med Chem; 2004 Oct 21; 47(22):5482-91. PubMed ID: 15481985
    [Abstract] [Full Text] [Related]

  • 20. The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.
    Balzarini J, Celen S, Karlsson A, de Groot T, Verbruggen A, Bormans G.
    Antivir Chem Chemother; 2006 Oct 21; 17(1):17-23. PubMed ID: 16542002
    [Abstract] [Full Text] [Related]

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