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158 related items for PubMed ID: 11599009

  • 1. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
    Popescu BO, Cedazo-Minguez A, Popescu LM, Winblad B, Cowburn RF, Ankarcrona M.
    J Neurosci Res; 2001 Oct 01; 66(1):122-34. PubMed ID: 11599009
    [Abstract] [Full Text] [Related]

  • 2. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
    Tanii H, Ankarcrona M, Flood F, Nilsberth C, Mehta ND, Perez-Tur J, Winblad B, Benedikz E, Cowburn RF.
    Neuroscience; 2000 Oct 01; 95(2):593-601. PubMed ID: 10658639
    [Abstract] [Full Text] [Related]

  • 3. Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress.
    Vestling M, Wiehager B, Tanii H, Cowburn RF.
    J Neurosci Res; 2001 Nov 01; 66(3):448-56. PubMed ID: 11746362
    [Abstract] [Full Text] [Related]

  • 4. Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.
    Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M.
    J Neurochem; 2006 Apr 01; 97(2):356-64. PubMed ID: 16539675
    [Abstract] [Full Text] [Related]

  • 5. Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Apr 01; 16(3):551-64. PubMed ID: 19276550
    [Abstract] [Full Text] [Related]

  • 6. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
    Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE.
    J Neurochem; 1999 Dec 01; 73(6):2278-85. PubMed ID: 10582585
    [Abstract] [Full Text] [Related]

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  • 8. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 9. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC, Ghadge GD, Miller RJ, Roos RP.
    J Neurochem; 1999 Jul 15; 73(1):31-40. PubMed ID: 10386952
    [Abstract] [Full Text] [Related]

  • 10. Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.
    Popescu BO, Cedazo-Minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, Cowburn RF.
    J Biol Chem; 2004 Feb 20; 279(8):6455-64. PubMed ID: 14625299
    [Abstract] [Full Text] [Related]

  • 11. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP.
    Neurobiol Dis; 2002 Oct 20; 11(1):2-19. PubMed ID: 12460542
    [Abstract] [Full Text] [Related]

  • 12. GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis.
    Bando Y, Katayama T, Aleshin AN, Manabe T, Tohyama M.
    Apoptosis; 2004 Jul 20; 9(4):501-8. PubMed ID: 15192333
    [Abstract] [Full Text] [Related]

  • 13. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
    Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.
    J Neurochem; 2006 Sep 20; 98(5):1610-8. PubMed ID: 16923170
    [Abstract] [Full Text] [Related]

  • 14. Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line.
    Flood F, Sundström E, Samuelsson EB, Wiehager B, Seiger A, Johnston JA, Cowburn RF.
    Neurochem Int; 2004 Jun 20; 44(7):487-96. PubMed ID: 15209417
    [Abstract] [Full Text] [Related]

  • 15. Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.
    Smith IF, Boyle JP, Vaughan PF, Pearson HA, Cowburn RF, Peers CS.
    Brain Res; 2002 Sep 13; 949(1-2):105-11. PubMed ID: 12213305
    [Abstract] [Full Text] [Related]

  • 16. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Sep 13; 16(3):565-75. PubMed ID: 19276551
    [Abstract] [Full Text] [Related]

  • 17. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.
    Cedazo-Minguez A, Popescu BO, Ankarcrona M, Nishimura T, Cowburn RF.
    J Biol Chem; 2002 Sep 27; 277(39):36646-55. PubMed ID: 12121968
    [Abstract] [Full Text] [Related]

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  • 19. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec 27; 1(8):479-85. PubMed ID: 10587643
    [Abstract] [Full Text] [Related]

  • 20. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
    Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE.
    Science; 1997 Jul 18; 277(5324):373-6. PubMed ID: 9219695
    [Abstract] [Full Text] [Related]

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