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Journal Abstract Search

354 related items for PubMed ID: 11684296

  • 1. Influence of relative binding affinity on efficacy in a panel of anti-CD3 scFv immunotoxins.
    Hexham JM, Dudas D, Hugo R, Thompson J, King V, Dowling C, Neville DM, Digan ME, Lake P.
    Mol Immunol; 2001 Sep; 38(5):397-408. PubMed ID: 11684296
    [Abstract] [Full Text] [Related]

  • 2. Optimization of the anti-(human CD3) immunotoxin DT389-scFv(UCHT1) N-terminal sequence to yield a homogeneous protein.
    Hexham JM, King V, Dudas D, Graff P, Mahnke M, Wang YK, Goetschy JF, Plattner D, Zurini M, Bitsch F, Lake P, Digan ME.
    Biotechnol Appl Biochem; 2001 Dec; 34(3):183-7. PubMed ID: 11730486
    [Abstract] [Full Text] [Related]

  • 3. Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion.
    Thompson J, Stavrou S, Weetall M, Hexham JM, Digan ME, Wang Z, Woo JH, Yu Y, Mathias A, Liu YY, Ma S, Gordienko I, Lake P, Neville DM.
    Protein Eng; 2001 Dec; 14(12):1035-41. PubMed ID: 11809934
    [Abstract] [Full Text] [Related]

  • 4. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
    Benhar I, Pastan I.
    Clin Cancer Res; 1995 Sep; 1(9):1023-9. PubMed ID: 9816075
    [Abstract] [Full Text] [Related]

  • 5. Construction and in vitro evaluation of RFT5(scFv)-ETA', a new recombinant single-chain immunotoxin with specific cytotoxicity toward CD25+ Hodgkin-derived cell lines.
    Barth S, Huhn M, Wels W, Diehl V, Engert A.
    Int J Mol Med; 1998 Jan; 1(1):249-56. PubMed ID: 9852227
    [Abstract] [Full Text] [Related]

  • 6. New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells.
    Du X, Ho M, Pastan I.
    J Immunother; 2007 Sep; 30(6):607-13. PubMed ID: 17667524
    [Abstract] [Full Text] [Related]

  • 7. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
    Benhar I, Pastan I.
    J Biol Chem; 1995 Oct 06; 270(40):23373-80. PubMed ID: 7559495
    [Abstract] [Full Text] [Related]

  • 8. Target-specific cytotoxic activity of recombinant immunotoxin scFv(MUC1)-ETA on breast carcinoma cells and primary breast tumors.
    Singh R, Samant U, Hyland S, Chaudhari PR, Wels WS, Bandyopadhyay D.
    Mol Cancer Ther; 2007 Feb 06; 6(2):562-9. PubMed ID: 17308054
    [Abstract] [Full Text] [Related]

  • 9. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.
    Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, FitzGerald DJ, Pastan I.
    Blood; 2009 Apr 16; 113(16):3792-800. PubMed ID: 18988862
    [Abstract] [Full Text] [Related]

  • 10. Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A.
    Onda M, Olafsen T, Tsutsumi Y, Bruland OS, Pastan I.
    J Immunother; 2001 Apr 16; 24(2):144-50. PubMed ID: 11265772
    [Abstract] [Full Text] [Related]

  • 11. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
    Reiter Y, Wright AF, Tonge DW, Pastan I.
    Int J Cancer; 1996 Jul 03; 67(1):113-23. PubMed ID: 8690511
    [Abstract] [Full Text] [Related]

  • 12. Recombinant immunotoxins for the treatment of Hodgkin's disease (Review).
    Matthey B, Engert A, Barth S.
    Int J Mol Med; 2000 Nov 03; 6(5):509-14. PubMed ID: 11029515
    [Abstract] [Full Text] [Related]

  • 13. Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
    Brinkmann U, Lee BK, Pastan I.
    J Immunol; 1993 Apr 01; 150(7):2774-82. PubMed ID: 8454854
    [Abstract] [Full Text] [Related]

  • 14. Improvement of a recombinant anti-monkey anti-CD3 diphtheria toxin based immunotoxin by yeast display affinity maturation of the scFv.
    Wang Z, Kim GB, Woo JH, Liu YY, Mathias A, Stavrou S, Neville DM.
    Bioconjug Chem; 2007 Apr 01; 18(3):947-55. PubMed ID: 17352456
    [Abstract] [Full Text] [Related]

  • 15. Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
    Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I.
    Cancer Res; 2001 Jul 01; 61(13):5070-7. PubMed ID: 11431343
    [Abstract] [Full Text] [Related]

  • 16. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
    Benhar I, Padlan EA, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1994 Dec 06; 91(25):12051-5. PubMed ID: 7991583
    [Abstract] [Full Text] [Related]

  • 17. In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA' in a human acute myeloid leukemia xenograft tumor model.
    Tur MK, Huhn M, Jost E, Thepen T, Brümmendorf TH, Barth S.
    Int J Cancer; 2011 Sep 01; 129(5):1277-82. PubMed ID: 21077160
    [Abstract] [Full Text] [Related]

  • 18. Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells.
    Tur MK, Huhn M, Thepen T, Stöcker M, Krohn R, Vogel S, Jost E, Osieka R, van de Winkel JG, Fischer R, Finnern R, Barth S.
    Cancer Res; 2003 Dec 01; 63(23):8414-9. PubMed ID: 14679004
    [Abstract] [Full Text] [Related]

  • 19. Design of a modular immunotoxin connected by polyionic adapter peptides.
    Kleinschmidt M, Rudolph R, Lilie H.
    J Mol Biol; 2003 Mar 21; 327(2):445-52. PubMed ID: 12628249
    [Abstract] [Full Text] [Related]

  • 20. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma.
    Onda M, Wang QC, Guo HF, Cheung NK, Pastan I.
    Cancer Res; 2004 Feb 15; 64(4):1419-24. PubMed ID: 14973056
    [Abstract] [Full Text] [Related]

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