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Journal Abstract Search

176 related items for PubMed ID: 11689072

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  • 2. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
    Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL.
    Chem Biol; 2001 Nov; 8(11):1107-21. PubMed ID: 11731301
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  • 3. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
    Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME.
    J Mol Biol; 2004 Nov 19; 344(2):527-47. PubMed ID: 15522303
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  • 7. Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
    Wendt MD, Rockway TW, Geyer A, McClellan W, Weitzberg M, Zhao X, Mantei R, Nienaber VL, Stewart K, Klinghofer V, Giranda VL.
    J Med Chem; 2004 Jan 15; 47(2):303-24. PubMed ID: 14711304
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  • 9. (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
    Sperl S, Jacob U, Arroyo de Prada N, Stürzebecher J, Wilhelm OG, Bode W, Magdolen V, Huber R, Moroder L.
    Proc Natl Acad Sci U S A; 2000 May 09; 97(10):5113-8. PubMed ID: 10805774
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  • 10. 3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis.
    Bhongade BA, Gouripur VV, Gadad AK.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2773-82. PubMed ID: 15781388
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  • 11. 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
    Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J.
    Bioorg Med Chem Lett; 2002 Aug 05; 12(15):2019-22. PubMed ID: 12113832
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  • 12. Comparative molecular modeling analysis of-5-amidinoindole and benzamidine binding to thrombin and trypsin: specific H-bond formation contributes to high 5-amidinoindole potency and selectivity for thrombin and factor Xa.
    Zhou Y, Johnson ME.
    J Mol Recognit; 1999 Aug 05; 12(4):235-41. PubMed ID: 10440994
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  • 13. Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
    West CW, Adler M, Arnaiz D, Chen D, Chu K, Gualtieri G, Ho E, Huwe C, Light D, Phillips G, Pulk R, Sukovich D, Whitlow M, Yuan S, Bryant J.
    Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5712-5. PubMed ID: 19703768
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  • 15. Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors.
    Zeslawska E, Jacob U, Schweinitz A, Coombs G, Bode W, Madison E.
    J Mol Biol; 2003 Apr 18; 328(1):109-18. PubMed ID: 12684001
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  • 18. Inhibitors of the protease domain of urokinase-type plasminogen activator.
    Rockway TW, Nienaber V, Giranda VL.
    Curr Pharm Des; 2002 Apr 18; 8(28):2541-58. PubMed ID: 12369939
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