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Journal Abstract Search

151 related items for PubMed ID: 11695901

  • 1.
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  • 2. New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
    Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA.
    Biochemistry; 1999 Dec 21; 38(51):16783-93. PubMed ID: 10606510
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  • 3. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
    Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606
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  • 5. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 27; 10(8):2739-49. PubMed ID: 12057663
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  • 6. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
    Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA.
    Biochemistry; 2002 Dec 03; 41(48):14206-15. PubMed ID: 12450384
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  • 8. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
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  • 9. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 01; 5(9):1847-52. PubMed ID: 9354240
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  • 10. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 01; 5(9):1839-46. PubMed ID: 9354239
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  • 11. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem Lett; 2000 Jul 03; 10(13):1471-5. PubMed ID: 10888335
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  • 12. Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
    Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM.
    Biochemistry; 2000 Aug 01; 39(30):8791-802. PubMed ID: 10913290
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  • 13. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
    Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA.
    Biochemistry; 2003 Sep 23; 42(37):10904-14. PubMed ID: 12974624
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  • 14. Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.
    Chen P, Schulze-Gahmen U, Stura EA, Inglese J, Johnson DL, Marolewski A, Benkovic SJ, Wilson IA.
    J Mol Biol; 1992 Sep 05; 227(1):283-92. PubMed ID: 1522592
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  • 18. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4487-501. PubMed ID: 13129585
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  • 20. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3593-9. PubMed ID: 15848772
    [Abstract] [Full Text] [Related]

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