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Journal Abstract Search

302 related items for PubMed ID: 11727321

  • 1. The prediction of human clearance from hepatic microsomal metabolism data.
    Obach RS.
    Curr Opin Drug Discov Devel; 2001 Jan; 4(1):36-44. PubMed ID: 11727321
    [Abstract] [Full Text] [Related]

  • 2. Use of intrinsic clearance for prediction of human hepatic clearance.
    Chao P, Uss AS, Cheng KC.
    Expert Opin Drug Metab Toxicol; 2010 Feb; 6(2):189-98. PubMed ID: 20073997
    [Abstract] [Full Text] [Related]

  • 3. [Advances and related issues in the use of in vitro methods to predict metabolic clearance rate of new drugs].
    Zhang Q, Wang GJ.
    Yao Xue Xue Bao; 2007 Oct; 42(10):1023-8. PubMed ID: 18229605
    [Abstract] [Full Text] [Related]

  • 4. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.
    Obach RS.
    Drug Metab Dispos; 1999 Nov; 27(11):1350-9. PubMed ID: 10534321
    [Abstract] [Full Text] [Related]

  • 5. Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.
    Hosea NA, Collard WT, Cole S, Maurer TS, Fang RX, Jones H, Kakar SM, Nakai Y, Smith BJ, Webster R, Beaumont K.
    J Clin Pharmacol; 2009 May; 49(5):513-33. PubMed ID: 19299532
    [Abstract] [Full Text] [Related]

  • 6. Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs.
    Nikolic K, Agababa D.
    J Mol Graph Model; 2009 Oct; 28(3):245-52. PubMed ID: 19713138
    [Abstract] [Full Text] [Related]

  • 7. Prediction of drug bioavailability in humans using immobilized artificial membrane phosphatidylcholine column chromatography and in vitro hepatic metabolic clearance.
    Shin BS, Yoon CH, Balthasar JP, Choi BY, Hong SH, Kim HJ, Lee JB, Hwang SW, Yoo SD.
    Biomed Chromatogr; 2009 Jul; 23(7):764-9. PubMed ID: 19296531
    [Abstract] [Full Text] [Related]

  • 8. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.
    Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, Rance DJ, Wastall P.
    J Pharmacol Exp Ther; 1997 Oct; 283(1):46-58. PubMed ID: 9336307
    [Abstract] [Full Text] [Related]

  • 9. Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
    Yang Z, Zadjura L, D'Arienzo C, Marino A, Santone K, Klunk L, Greene D, Lin PF, Colonno R, Wang T, Meanwell N, Hansel S.
    Biopharm Drug Dispos; 2005 Dec; 26(9):387-402. PubMed ID: 16142720
    [Abstract] [Full Text] [Related]

  • 10. The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.
    De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ.
    Drug Metab Dispos; 2007 Apr; 35(4):649-59. PubMed ID: 17267621
    [Abstract] [Full Text] [Related]

  • 11. Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data.
    Cubitt HE, Houston JB, Galetin A.
    Drug Metab Dispos; 2011 May; 39(5):864-73. PubMed ID: 21303923
    [Abstract] [Full Text] [Related]

  • 12. Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Oct; 59(10):1427-31. PubMed ID: 17910819
    [Abstract] [Full Text] [Related]

  • 13. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
    [Abstract] [Full Text] [Related]

  • 14. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y, Terashita S, Kimura S, Suzuki A, Kagayama A, Sugiyama Y.
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
    [Abstract] [Full Text] [Related]

  • 15. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.
    Miners JO, Knights KM, Houston JB, Mackenzie PI.
    Biochem Pharmacol; 2006 May 28; 71(11):1531-9. PubMed ID: 16455060
    [Abstract] [Full Text] [Related]

  • 16. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
    Obach RS.
    Drug Metab Dispos; 1997 Dec 28; 25(12):1359-69. PubMed ID: 9394025
    [Abstract] [Full Text] [Related]

  • 17. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.
    Shibata Y, Takahashi H, Ishii Y.
    Drug Metab Dispos; 2000 Dec 28; 28(12):1518-23. PubMed ID: 11095592
    [Abstract] [Full Text] [Related]

  • 18. Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.
    Camenisch G, Umehara K.
    Biopharm Drug Dispos; 2012 May 28; 33(4):179-94. PubMed ID: 22407504
    [Abstract] [Full Text] [Related]

  • 19. Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.
    Ashforth EI, Carlile DJ, Chenery R, Houston JB.
    J Pharmacol Exp Ther; 1995 Aug 28; 274(2):761-6. PubMed ID: 7636740
    [Abstract] [Full Text] [Related]

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