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Journal Abstract Search

302 related items for PubMed ID: 11727321

  • 21. Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro.
    Kuhnz W, Gieschen H.
    Drug Metab Dispos; 1998 Nov; 26(11):1120-7. PubMed ID: 9806955
    [Abstract] [Full Text] [Related]

  • 22. Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.
    De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA.
    Drug Metab Dispos; 2007 Oct; 35(10):1766-80. PubMed ID: 17620347
    [Abstract] [Full Text] [Related]

  • 23. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.
    McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ.
    Drug Metab Dispos; 2004 Nov; 32(11):1247-53. PubMed ID: 15286053
    [Abstract] [Full Text] [Related]

  • 24. Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage.
    Emoto C, Murase S, Iwasaki K.
    Xenobiotica; 2006 Aug; 36(8):671-83. PubMed ID: 16891248
    [Abstract] [Full Text] [Related]

  • 25. Direct determination of unbound intrinsic drug clearance in the microsomal stability assay.
    Giuliano C, Jairaj M, Zafiu CM, Laufer R.
    Drug Metab Dispos; 2005 Sep; 33(9):1319-24. PubMed ID: 15951446
    [Abstract] [Full Text] [Related]

  • 26. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ, McGinnity DF, Austin RP.
    Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
    [Abstract] [Full Text] [Related]

  • 27. Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance.
    Ekins S, Obach RS.
    J Pharmacol Exp Ther; 2000 Nov; 295(2):463-73. PubMed ID: 11046077
    [Abstract] [Full Text] [Related]

  • 28. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
    Brown HS, Griffin M, Houston JB.
    Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
    [Abstract] [Full Text] [Related]

  • 29. The use of single sample clearance estimates to probe hepatic drug metabolism: handprinting the influence of cigarette smoking on human hepatic drug metabolism.
    Bachmann KA, Nunlee M, Martin M, Schwartz J, Jauregui L, Forney RB.
    Xenobiotica; 1990 May; 20(5):537-47. PubMed ID: 2112290
    [Abstract] [Full Text] [Related]

  • 30. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 31. Prediction of human pharmacokinetics--gut-wall metabolism.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Oct; 59(10):1335-43. PubMed ID: 17910807
    [Abstract] [Full Text] [Related]

  • 32. Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.
    Kilford PJ, Gertz M, Houston JB, Galetin A.
    Drug Metab Dispos; 2008 Jul; 36(7):1194-7. PubMed ID: 18411401
    [Abstract] [Full Text] [Related]

  • 33. Criticism of pharmacokinetic clearance concepts.
    Keller F, Schoole J.
    Int J Clin Pharmacol Ther Toxicol; 1983 Nov; 21(11):563-8. PubMed ID: 6654532
    [Abstract] [Full Text] [Related]

  • 34. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fu p/fu mic) for refined prediction of phase I mediated metabolic hepatic clearance.
    Deshmukh SV, Harsch A.
    J Pharmacol Toxicol Methods; 2011 Nov; 63(1):35-9. PubMed ID: 20433934
    [Abstract] [Full Text] [Related]

  • 35. A new model-independent physiological approach to study hepatic drug clearance and its applications.
    Chiou WL.
    Int J Clin Pharmacol Ther Toxicol; 1984 Nov; 22(11):577-90. PubMed ID: 6389376
    [Abstract] [Full Text] [Related]

  • 36. Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.
    Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A.
    Drug Metab Dispos; 2009 Jan; 37(1):82-9. PubMed ID: 18832476
    [Abstract] [Full Text] [Related]

  • 37. [Development of antituberculous drugs: current status and future prospects].
    Tomioka H, Namba K.
    Kekkaku; 2006 Dec; 81(12):753-74. PubMed ID: 17240921
    [Abstract] [Full Text] [Related]

  • 38.
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  • 39. Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
    Watanabe T, Maeda K, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
    Drug Metab Dispos; 2009 Jul; 37(7):1471-9. PubMed ID: 19364828
    [Abstract] [Full Text] [Related]

  • 40. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM, Houston JB.
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
    [Abstract] [Full Text] [Related]

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