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Journal Abstract Search

712 related items for PubMed ID: 11744168

  • 1. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL.
    Brain Res Mol Brain Res; 2001 Dec 16; 97(1):103-13. PubMed ID: 11744168
    [Abstract] [Full Text] [Related]

  • 2. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
    Nunan J, Shearman MS, Checler F, Cappai R, Evin G, Beyreuther K, Masters CL, Small DH.
    Eur J Biochem; 2001 Oct 16; 268(20):5329-36. PubMed ID: 11606195
    [Abstract] [Full Text] [Related]

  • 3. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 16; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 4. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A, Hata S, Suzuki T.
    J Biol Chem; 2016 Nov 11; 291(46):24041-24053. PubMed ID: 27687728
    [Abstract] [Full Text] [Related]

  • 5. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 11; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 6. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 7. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
    Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S.
    Acta Neuropathol Commun; 2023 Jun 01; 11(1):87. PubMed ID: 37259128
    [Abstract] [Full Text] [Related]

  • 8. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 01; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 9. Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.
    Pellegrini L, Passer BJ, Tabaton M, Ganjei JK, D'Adamio L.
    J Biol Chem; 1999 Jul 23; 274(30):21011-6. PubMed ID: 10409650
    [Abstract] [Full Text] [Related]

  • 10. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.
    McPhie DL, Lee RK, Eckman CB, Olstein DH, Durham SP, Yager D, Younkin SG, Wurtman RJ, Neve RL.
    J Biol Chem; 1997 Oct 03; 272(40):24743-6. PubMed ID: 9312066
    [Abstract] [Full Text] [Related]

  • 11. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 03; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 12. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS.
    J Biol Chem; 1996 Apr 19; 271(16):9390-7. PubMed ID: 8621605
    [Abstract] [Full Text] [Related]

  • 13. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
    Tomita S, Kirino Y, Suzuki T.
    J Biol Chem; 1998 Mar 13; 273(11):6277-84. PubMed ID: 9497354
    [Abstract] [Full Text] [Related]

  • 14. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K.
    Am J Geriatr Psychiatry; 2013 May 13; 21(5):474-83. PubMed ID: 23570890
    [Abstract] [Full Text] [Related]

  • 15. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S, Refolo LM, Sambamurti K.
    J Mol Neurosci; 2004 May 13; 24(1):137-43. PubMed ID: 15314262
    [Abstract] [Full Text] [Related]

  • 16. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
    Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW.
    Cell; 1999 Apr 30; 97(3):395-406. PubMed ID: 10319819
    [Abstract] [Full Text] [Related]

  • 17. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.
    De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B.
    Hum Mol Genet; 2001 Aug 01; 10(16):1665-71. PubMed ID: 11487570
    [Abstract] [Full Text] [Related]

  • 18. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
    Kinoshita A, Whelan CM, Berezovska O, Hyman BT.
    J Biol Chem; 2002 Aug 09; 277(32):28530-6. PubMed ID: 12032152
    [Abstract] [Full Text] [Related]

  • 19. Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay.
    Law BM, Guest AL, Pullen MWJ, Perkinton MS, Williams RJ.
    J Alzheimers Dis; 2018 Aug 09; 61(2):673-688. PubMed ID: 29254083
    [Abstract] [Full Text] [Related]

  • 20. Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.
    Zhang W, Espinoza D, Hines V, Innis M, Mehta P, Miller DL.
    Biochim Biophys Acta; 1997 Nov 27; 1359(2):110-22. PubMed ID: 9409808
    [Abstract] [Full Text] [Related]

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