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109 related items for PubMed ID: 11786382

  • 1. Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin.
    Annerén C.
    J Endocrinol; 2002 Jan; 172(1):145-53. PubMed ID: 11786382
    [Abstract] [Full Text] [Related]

  • 2. Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK.
    Annerén C, Welsh M.
    Mol Med; 2001 May; 7(5):301-10. PubMed ID: 11474576
    [Abstract] [Full Text] [Related]

  • 3. GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
    Annerén C, Welsh M.
    Mol Med; 2002 Nov; 8(11):705-13. PubMed ID: 12520087
    [Abstract] [Full Text] [Related]

  • 4. Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.
    Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.
    Mol Med; 1999 Mar; 5(3):169-80. PubMed ID: 10404514
    [Abstract] [Full Text] [Related]

  • 5. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.
    Welsh N, Makeeva N, Welsh M.
    Mol Med; 2002 Nov; 8(11):695-704. PubMed ID: 12520086
    [Abstract] [Full Text] [Related]

  • 6. Role of tyrosine kinase signaling for beta-cell replication and survival.
    Welsh M, Annerén C, Lindholm C, Kriz V, Oberg-Welsh C.
    Ups J Med Sci; 2000 Nov; 105(2):7-15. PubMed ID: 11095102
    [Abstract] [Full Text] [Related]

  • 7. GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase.
    Annerén C, Reedquist KA, Bos JL, Welsh M.
    J Biol Chem; 2000 Sep 15; 275(37):29153-61. PubMed ID: 10878015
    [Abstract] [Full Text] [Related]

  • 8. The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.
    Annerén C, Lindholm CK, Kriz V, Welsh M.
    Curr Mol Med; 2003 Jun 15; 3(4):313-24. PubMed ID: 12776987
    [Abstract] [Full Text] [Related]

  • 9. Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets.
    Alenkvist I, Dyachok O, Tian G, Li J, Mehrabanfar S, Jin Y, Birnir B, Tengholm A, Welsh M.
    J Endocrinol; 2014 Dec 15; 223(3):267-75. PubMed ID: 25274988
    [Abstract] [Full Text] [Related]

  • 10. Impaired glucose homeostasis in Shb-/- mice.
    Akerblom B, Barg S, Calounova G, Mokhtari D, Jansson L, Welsh M.
    J Endocrinol; 2009 Nov 15; 203(2):271-9. PubMed ID: 19696098
    [Abstract] [Full Text] [Related]

  • 11. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells.
    Karlsson T, Kullander K, Welsh M.
    Cell Growth Differ; 1998 Sep 15; 9(9):757-66. PubMed ID: 9751119
    [Abstract] [Full Text] [Related]

  • 12. Shb is a ubiquitously expressed Src homology 2 protein.
    Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L.
    Oncogene; 1994 Jan 15; 9(1):19-27. PubMed ID: 8302579
    [Abstract] [Full Text] [Related]

  • 13. In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.
    Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.
    Diabetologia; 2004 Oct 15; 47(10):1819-30. PubMed ID: 15480536
    [Abstract] [Full Text] [Related]

  • 14. Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes.
    Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M, Gomis R.
    Diabetologia; 2004 Apr 15; 47(4):686-94. PubMed ID: 15298346
    [Abstract] [Full Text] [Related]

  • 15. Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia.
    Jamalpour M, Li X, Gustafsson K, Tyner JW, Welsh M.
    Tumour Biol; 2018 Apr 15; 40(4):1010428318771472. PubMed ID: 29792386
    [Abstract] [Full Text] [Related]

  • 16. Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.
    Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.
    Diabetes; 2002 Oct 15; 51(10):3003-13. PubMed ID: 12351440
    [Abstract] [Full Text] [Related]

  • 17. mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice.
    Li W, Zhang H, Nie A, Ni Q, Li F, Ning G, Li X, Gu Y, Wang Q.
    Endocrine; 2016 Jul 15; 53(1):117-28. PubMed ID: 26818915
    [Abstract] [Full Text] [Related]

  • 18. The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.
    Welsh M, Welsh C, Ekman M, Dixelius J, Hägerkvist R, Annerén C, Akerblom B, Mahboobi S, Chandrasekharan S, Liu ET.
    Biochem J; 2004 Aug 15; 382(Pt 1):261-8. PubMed ID: 15186217
    [Abstract] [Full Text] [Related]

  • 19. Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter.
    Annerén C, Welsh M, Jansson L.
    Am J Physiol Endocrinol Metab; 2007 Apr 15; 292(4):E1183-90. PubMed ID: 17179392
    [Abstract] [Full Text] [Related]

  • 20. Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice.
    Mokhtari D, Kerblom B, Mehmeti I, Wang X, Funa NS, Olerud J, Lenzen S, Welsh N, Welsh M.
    Biochem Biophys Res Commun; 2009 Sep 25; 387(3):553-7. PubMed ID: 19615333
    [Abstract] [Full Text] [Related]

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