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Journal Abstract Search

128 related items for PubMed ID: 11792684

  • 1. Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.
    Yamamoto Y, Yamazaki H, Ikeda T, Watanabe T, Iwabuchi H, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2002 Feb; 30(2):155-60. PubMed ID: 11792684
    [Abstract] [Full Text] [Related]

  • 2. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes.
    Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T.
    Drug Metab Dispos; 1999 Nov; 27(11):1260-6. PubMed ID: 10534310
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  • 3. Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
    He K, Woolf TF, Kindt EK, Fielder AE, Talaat RE.
    Biochem Pharmacol; 2001 Jul 15; 62(2):191-8. PubMed ID: 11389877
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  • 4. Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells.
    Yamamoto Y, Nakajima M, Yamazaki H, Yokoi T.
    Life Sci; 2001 Dec 14; 70(4):471-82. PubMed ID: 11798015
    [Abstract] [Full Text] [Related]

  • 5. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
    Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.
    Chem Res Toxicol; 2001 Jan 14; 14(1):62-70. PubMed ID: 11170509
    [Abstract] [Full Text] [Related]

  • 6. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug 14; 14(8):965-74. PubMed ID: 11511170
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  • 7. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

  • 8. An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.
    Vignati L, Turlizzi E, Monaci S, Grossi P, Kanter Rd, Monshouwer M.
    Toxicology; 2005 Dec 15; 216(2-3):154-67. PubMed ID: 16169652
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  • 9. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
    Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW.
    Drug Metab Dispos; 2003 Apr 15; 31(4):439-46. PubMed ID: 12642470
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  • 11. The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.
    Kostrubsky VE, Sinclair JF, Ramachandran V, Venkataramanan R, Wen YH, Kindt E, Galchev V, Rose K, Sinz M, Strom SC.
    Drug Metab Dispos; 2000 Oct 15; 28(10):1192-7. PubMed ID: 10997939
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  • 13. Toxic effect of troglitazone on cultured rat hepatocytes.
    Toyoda Y, Tsuchida A, Iwami E, Miwa I.
    Life Sci; 2001 Mar 09; 68(16):1867-76. PubMed ID: 11292064
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  • 14. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.
    Kubota T, Koshizuka K, Williamson EA, Asou H, Said JW, Holden S, Miyoshi I, Koeffler HP.
    Cancer Res; 1998 Aug 01; 58(15):3344-52. PubMed ID: 9699665
    [Abstract] [Full Text] [Related]

  • 15. Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.
    Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I.
    Drug Metab Dispos; 2004 Mar 01; 32(3):291-4. PubMed ID: 14977862
    [Abstract] [Full Text] [Related]

  • 16. Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver.
    Honma W, Shimada M, Sasano H, Ozawa S, Miyata M, Nagata K, Ikeda T, Yamazoe Y.
    Drug Metab Dispos; 2002 Aug 01; 30(8):944-9. PubMed ID: 12124314
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  • 18. Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors.
    Lloyd S, Hayden MJ, Sakai Y, Fackett A, Silber PM, Hewitt NJ, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):57-71. PubMed ID: 12399155
    [Abstract] [Full Text] [Related]

  • 19. Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells.
    Yoshida K, Tanabe K, Fujii D, Oue N, Yasui W, Toge T.
    Anticancer Res; 2003 Nov 10; 23(1A):267-73. PubMed ID: 12680223
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