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Journal Abstract Search

186 related items for PubMed ID: 11814784

  • 1. Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
    Mewshaw RE, Meagher KL, Zhou P, Zhou D, Shi X, Scerni R, Smith D, Schechter LE, Andree TH.
    Bioorg Med Chem Lett; 2002 Feb 11; 12(3):307-10. PubMed ID: 11814784
    [Abstract] [Full Text] [Related]

  • 2. Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.
    Ryckmans T, Berton O, Grimée R, Kogej T, Lamberty Y, Pasau P, Talaga P, Genicot C.
    Bioorg Med Chem Lett; 2002 Nov 04; 12(21):3195-8. PubMed ID: 12372532
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  • 4. New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
    Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A.
    J Med Chem; 2001 Feb 01; 44(3):418-28. PubMed ID: 11462981
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  • 5. Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
    Orús L, Pérez-Silanes S, Oficialdegui AM, Martínez-Esparza J, Del Castillo JC, Mourelle M, Langer T, Guccione S, Donzella G, Krovat EM, Poptodorov K, Lasheras B, Ballaz S, Hervías I, Tordera R, Del Río J, Monge A.
    J Med Chem; 2002 Sep 12; 45(19):4128-39. PubMed ID: 12213056
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  • 8. Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
    Moreau X, Jeanningros R, Mazzola-Pomietto P.
    Neuropsychopharmacology; 2001 Jun 12; 24(6):652-62. PubMed ID: 11331145
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  • 9. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
    Orjales A, Mosquera R, Toledo A, Pumar MC, García N, Cortizo L, Labeaga L, Innerárity A.
    J Med Chem; 2003 Dec 04; 46(25):5512-32. PubMed ID: 14640559
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  • 10. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
    Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH.
    J Med Chem; 2004 Jul 15; 47(15):3823-42. PubMed ID: 15239661
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  • 11. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity.
    Mannoury la Cour C, Boni C, Hanoun N, Lesch KP, Hamon M, Lanfumey L.
    J Neurosci; 2001 Mar 15; 21(6):2178-85. PubMed ID: 11245702
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  • 12. Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.
    Takeuchi K, Kohn TJ, Honigschmidt NA, Rocco VP, Spinazze PG, Koch DJ, Atkinson ST, Hertel LW, Nelson DL, Wainscott DB, Ahmad LJ, Shaw J, Threlkeld PG, Wong DT.
    Bioorg Med Chem Lett; 2003 Jul 21; 13(14):2393-7. PubMed ID: 12824042
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  • 13. Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain.
    Duncan MJ, Hensler JG.
    Neuropharmacology; 2002 Jul 21; 43(1):36-44. PubMed ID: 12213257
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  • 14. 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
    Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Böttcher H.
    J Med Chem; 2000 Mar 23; 43(6):1149-57. PubMed ID: 10737747
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  • 15. New 3-[4-(2,3-dihydro-14-benzodioxin-5-yl)piperazin-1-yl]-1-(5-substituted benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT(1A) serotonin receptors and serotonin transporter as a new class of antidepressants.
    Silanes SP, Orús L, Oficialdegui AM, Martínez Esparza J, Lasheras B, Del Río J, Monge A.
    Pharmazie; 2004 Jul 23; 59(7):499-501. PubMed ID: 15296084
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  • 16. Trazodone increases extracellular serotonin levels in the frontal cortex of rats.
    Pazzagli M, Giovannini MG, Pepeu G.
    Eur J Pharmacol; 1999 Nov 03; 383(3):249-57. PubMed ID: 10594316
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  • 17. Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.
    Evrard DA, Zhou P, Yi SY, Zhou D, Smith DL, Sullivan KM, Hornby GA, Schechter LE, Andree TH, Mewshaw RE.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):911-4. PubMed ID: 15686885
    [Abstract] [Full Text] [Related]

  • 18. Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1.
    Takeuchi K, Kohn TJ, Honigschmidt NA, Rocco VP, Spinazze PG, Koch DJ, Nelson DL, Wainscott DB, Ahmad LJ, Shaw J, Threlkeld PG, Wong DT.
    Bioorg Med Chem Lett; 2003 Jun 02; 13(11):1903-5. PubMed ID: 12749894
    [Abstract] [Full Text] [Related]

  • 19. Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4.
    Rocco VP, Spinazze PG, Kohn TJ, Honigschmidt NA, Nelson DL, Bradley Wainscott D, Ahmad LJ, Shaw J, Threlkeld PG, Wong DT, Takeuchi K.
    Bioorg Med Chem Lett; 2004 May 17; 14(10):2653-6. PubMed ID: 15109671
    [Abstract] [Full Text] [Related]

  • 20. 5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice.
    Monaca C, Boutrel B, Hen R, Hamon M, Adrien J.
    Neuropsychopharmacology; 2003 May 17; 28(5):850-6. PubMed ID: 12637954
    [Abstract] [Full Text] [Related]

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