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Journal Abstract Search

160 related items for PubMed ID: 11831901

  • 1. Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
    Wakelin LP, Adams A, Denny WA.
    J Med Chem; 2002 Feb 14; 45(4):894-901. PubMed ID: 11831901
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
    Adams A, Guss JM, Collyer CA, Denny WA, Wakelin LP.
    Biochemistry; 1999 Jul 20; 38(29):9221-33. PubMed ID: 10413496
    [Abstract] [Full Text] [Related]

  • 3. Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons.
    Adams A, Guss JM, Denny WA, Wakelin LP.
    Nucleic Acids Res; 2002 Feb 01; 30(3):719-25. PubMed ID: 11809884
    [Abstract] [Full Text] [Related]

  • 4. Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
    Adams A, Guss JM, Collyer CA, Denny WA, Prakash AS, Wakelin LP.
    Mol Pharmacol; 2000 Sep 01; 58(3):649-58. PubMed ID: 10953060
    [Abstract] [Full Text] [Related]

  • 5. Cytotoxic and DNA-damaging properties of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and its analogues.
    Pastwa E, Ciesielska E, Piestrzeniewicz MK, Denny WA, Gniazdowski M, Szmigiero L.
    Biochem Pharmacol; 1998 Aug 01; 56(3):351-9. PubMed ID: 9744573
    [Abstract] [Full Text] [Related]

  • 6. Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.
    Bridewell DJ, Finlay GJ, Baguley BC.
    Cancer Chemother Pharmacol; 1999 Aug 01; 43(4):302-8. PubMed ID: 10071981
    [Abstract] [Full Text] [Related]

  • 7. Molecular modeling study of intercalation complexes of tricyclic carboxamides with d(CCGGCGCCGG)₂ and d(CGCGAATTCGCG)₂.
    Varvaresou A, Iakovou K.
    J Mol Model; 2011 Aug 01; 17(8):2041-50. PubMed ID: 21153908
    [Abstract] [Full Text] [Related]

  • 8. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
    Todd AK, Adams A, Thorpe JH, Denny WA, Wakelin LP, Cardin CJ.
    J Med Chem; 1999 Feb 25; 42(4):536-40. PubMed ID: 10052960
    [No Abstract] [Full Text] [Related]

  • 9. From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives.
    Finlay GJ, Riou JF, Baguley BC.
    Eur J Cancer; 1996 Apr 25; 32A(4):708-14. PubMed ID: 8695277
    [Abstract] [Full Text] [Related]

  • 10. Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
    Wakelin LP, Bu X, Eleftheriou A, Parmar A, Hayek C, Stewart BW.
    J Med Chem; 2003 Dec 18; 46(26):5790-802. PubMed ID: 14667232
    [Abstract] [Full Text] [Related]

  • 11. Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
    Wakelin LP, Atwell GJ, Rewcastle GW, Denny WA.
    J Med Chem; 1987 May 18; 30(5):855-61. PubMed ID: 3572974
    [Abstract] [Full Text] [Related]

  • 12. In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines.
    Wolf SJ, Wakelin LP, He Z, Stewart BW, Catchpoole DR.
    Cancer Chemother Pharmacol; 2009 Nov 18; 64(6):1059-69. PubMed ID: 19277661
    [Abstract] [Full Text] [Related]

  • 13. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells.
    Padget K, Stewart A, Charlton P, Tilby MJ, Austin CA.
    Biochem Pharmacol; 2000 Sep 15; 60(6):817-21. PubMed ID: 10930536
    [Abstract] [Full Text] [Related]

  • 14. Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues.
    Osman S, Rowlinson-Busza G, Luthra SK, Aboagye EO, Brown GD, Brady F, Myers R, Gamage SA, Denny WA, Baguley BC, Price PM.
    Cancer Res; 2001 Apr 01; 61(7):2935-44. PubMed ID: 11306471
    [Abstract] [Full Text] [Related]

  • 15. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells.
    Hicks KO, Pruijn FB, Baguley BC, Wilson WR.
    J Pharmacol Exp Ther; 2001 Jun 01; 297(3):1088-98. PubMed ID: 11356933
    [Abstract] [Full Text] [Related]

  • 16. Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs.
    Spicer JA, Gamage SA, Rewcastle GW, Finlay GJ, Bridewell DJ, Baguley BC, Denny WA.
    J Med Chem; 2000 Apr 06; 43(7):1350-8. PubMed ID: 10753472
    [Abstract] [Full Text] [Related]

  • 17. 5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.
    Spicer JA, Finlay GJ, Baguley BC, Velea L, Graves DE, Denny WA.
    Anticancer Drug Des; 1999 Feb 06; 14(1):37-45. PubMed ID: 10363026
    [Abstract] [Full Text] [Related]

  • 18. Induction of mitotic crossing-over by the topoisomerase II poison DACA (N-[2-dimethylamino)ethyl]acridine-4-carboxamide) in Saccharomyces cerevisiae.
    Ferguson LR, Turner PM, Baguley BC.
    Mutat Res; 1993 Oct 06; 289(2):157-63. PubMed ID: 7690883
    [Abstract] [Full Text] [Related]

  • 19. Cellular uptake of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).
    Haldane A, Finlay GJ, Hay MP, Denny WA, Baguley BC.
    Anticancer Drug Des; 1999 Jun 06; 14(3):275-80. PubMed ID: 10500502
    [Abstract] [Full Text] [Related]

  • 20. X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.
    Hopcroft NH, Brogden AL, Searcey M, Cardin CJ.
    Nucleic Acids Res; 2006 Jun 06; 34(22):6663-72. PubMed ID: 17145714
    [Abstract] [Full Text] [Related]

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