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Journal Abstract Search

196 related items for PubMed ID: 11846636

  • 1. Preclinical safety evaluation of recombinant human interleukin-10.
    Rosenblum IY, Johnson RC, Schmahai TJ.
    Regul Toxicol Pharmacol; 2002 Feb; 35(1):56-71. PubMed ID: 11846636
    [Abstract] [Full Text] [Related]

  • 2. Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies.
    Ponce R, Abad L, Amaravadi L, Gelzleichter T, Gore E, Green J, Gupta S, Herzyk D, Hurst C, Ivens IA, Kawabata T, Maier C, Mounho B, Rup B, Shankar G, Smith H, Thomas P, Wierda D.
    Regul Toxicol Pharmacol; 2009 Jul; 54(2):164-82. PubMed ID: 19345250
    [Abstract] [Full Text] [Related]

  • 3. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
    EFSA GMO Panel Working Group on Animal Feeding Trials.
    Food Chem Toxicol; 2008 Mar; 46 Suppl 1():S2-70. PubMed ID: 18328408
    [Abstract] [Full Text] [Related]

  • 4. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.
    Int J Toxicol; 2007 Mar; 26 Suppl 1():3-106. PubMed ID: 17365137
    [Abstract] [Full Text] [Related]

  • 5. Safety pharmacology, toxicology and pharmacokinetic assessment of recombinant human omega-interferon produced from CHO-SS cells.
    Buckwold VE, Lang W, Scribner C, Blanchett D, Alessi T, Langecker P.
    Basic Clin Pharmacol Toxicol; 2006 Jul; 99(1):62-70. PubMed ID: 16867173
    [Abstract] [Full Text] [Related]

  • 6. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 7. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.
    Int J Toxicol; 2008 Nov; 27 Suppl 4():1-82. PubMed ID: 19101832
    [Abstract] [Full Text] [Related]

  • 8. Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
    Müller L, Gocke E, Lavé T, Pfister T.
    Toxicol Lett; 2009 Nov 12; 190(3):317-29. PubMed ID: 19443141
    [Abstract] [Full Text] [Related]

  • 9. NTP Toxicology and Carcinogenesis Studies of Salicylazosulfapyridine (CAS No. 599-79-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
    National Toxicology Program .
    Natl Toxicol Program Tech Rep Ser; 1997 May 12; 457():1-327. PubMed ID: 12587019
    [Abstract] [Full Text] [Related]

  • 10. The timing of preclinical toxicological studies: pharmaceutical company approaches to toxicity testing in support of initial clinical investigations.
    Parkinson C, Thomas KE, Lumley CE.
    Regul Toxicol Pharmacol; 1996 Apr 12; 23(2):162-72. PubMed ID: 8661335
    [Abstract] [Full Text] [Related]

  • 11. Amended final report on the safety assessment of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate.
    Int J Toxicol; 2007 Apr 12; 26 Suppl 3():1-30. PubMed ID: 18273450
    [Abstract] [Full Text] [Related]

  • 12. Alternative strategies for toxicity testing of species-specific biopharmaceuticals.
    Bussiere JL, Martin P, Horner M, Couch J, Flaherty M, Andrews L, Beyer J, Horvath C.
    Int J Toxicol; 2009 Apr 12; 28(3):230-53. PubMed ID: 19546261
    [Abstract] [Full Text] [Related]

  • 13. Preclinical safety evaluation of monoclonal antibodies.
    Lynch CM, Grewal IS.
    Handb Exp Pharmacol; 2008 Apr 12; (181):19-44. PubMed ID: 18071940
    [Abstract] [Full Text] [Related]

  • 14. Safety evaluation of biological drugs: what are toxicology studies in primates telling us?
    Baldrick P.
    Regul Toxicol Pharmacol; 2011 Mar 12; 59(2):227-36. PubMed ID: 20937341
    [Abstract] [Full Text] [Related]

  • 15. Safety evaluation to support First-In-Man investigations II: toxicology studies.
    Baldrick P.
    Regul Toxicol Pharmacol; 2008 Jul 12; 51(2):237-43. PubMed ID: 18501490
    [Abstract] [Full Text] [Related]

  • 16. High dose selection in general toxicity studies for drug development: A pharmaceutical industry perspective.
    Buckley LA, Dorato MA.
    Regul Toxicol Pharmacol; 2009 Aug 12; 54(3):301-7. PubMed ID: 19477212
    [Abstract] [Full Text] [Related]

  • 17. Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.
    Cosmetic Ingredient Review Expert PanelCosmetic Ingredient Review, Washington DC 20036, USA..
    Int J Toxicol; 2008 Aug 12; 27 Suppl 1():1-43. PubMed ID: 18569160
    [Abstract] [Full Text] [Related]

  • 18. Safety evaluation of recombinant human interleukin-4. I. Preclinical studies.
    Leach MW, Snyder EA, Sinha DP, Rosenblum IY.
    Clin Immunol Immunopathol; 1997 Apr 12; 83(1):8-11. PubMed ID: 9073526
    [Abstract] [Full Text] [Related]

  • 19. Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH).
    Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Kramer PJ, Schweinfurth H, Wollin KM.
    Arch Toxicol; 2008 Apr 12; 82(4):211-36. PubMed ID: 18322675
    [Abstract] [Full Text] [Related]

  • 20. Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
    Giardina WJ, Dart MJ, Harris RR, Bitner RS, Radek RJ, Fox GB, Chemburkar SR, Marsh KC, Waring JF, Hui JY, Chen J, Curzon P, Grayson GK, Komater VA, Ku Y, Lockwood M, Miner HM, Nikkel AL, Pan JB, Pu YM, Wang L, Bennani Y, Durmuller N, Jolly R, Roux S, Sullivan JP, Decker MW.
    Epilepsia; 2005 Sep 12; 46(9):1349-61. PubMed ID: 16146429
    [Abstract] [Full Text] [Related]

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