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175 related items for PubMed ID: 11854269

  • 1. ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
    Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD.
    J Biol Chem; 2002 May 03; 277(18):16059-66. PubMed ID: 11854269
    [Abstract] [Full Text] [Related]

  • 2. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
    Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M.
    J Biol Chem; 1995 Feb 10; 270(6):2550-6. PubMed ID: 7852317
    [Abstract] [Full Text] [Related]

  • 3. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
    Tortorella MD, Pratta M, Liu RQ, Austin J, Ross OH, Abbaszade I, Burn T, Arner E.
    J Biol Chem; 2000 Jun 16; 275(24):18566-73. PubMed ID: 10751421
    [Abstract] [Full Text] [Related]

  • 4. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
    Mercuri FA, Doege KJ, Arner EC, Pratta MA, Last K, Fosang AJ.
    J Biol Chem; 1999 Nov 05; 274(45):32387-95. PubMed ID: 10542281
    [Abstract] [Full Text] [Related]

  • 5. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ.
    J Biol Chem; 2000 Oct 20; 275(42):33038-45. PubMed ID: 11032846
    [Abstract] [Full Text] [Related]

  • 6. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD, Pratta MA, Fox JW, Arner EC.
    J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721
    [Abstract] [Full Text] [Related]

  • 7. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
    Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H.
    J Biol Chem; 2004 Mar 12; 279(11):10109-19. PubMed ID: 14662755
    [Abstract] [Full Text] [Related]

  • 8. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov 12; 19(6):533-43. PubMed ID: 11068207
    [Abstract] [Full Text] [Related]

  • 9. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA.
    J Biol Chem; 1992 Sep 25; 267(27):19470-4. PubMed ID: 1326552
    [Abstract] [Full Text] [Related]

  • 10. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [Abstract] [Full Text] [Related]

  • 11. ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
    Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD.
    J Biol Chem; 2004 Mar 12; 279(11):10042-51. PubMed ID: 14701864
    [Abstract] [Full Text] [Related]

  • 12. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.
    Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y.
    J Biol Chem; 2000 Dec 08; 275(49):38885-90. PubMed ID: 10986281
    [Abstract] [Full Text] [Related]

  • 13. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R.
    Biochem J; 1995 Apr 01; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4).
    Hashimoto G, Aoki T, Nakamura H, Tanzawa K, Okada Y.
    FEBS Lett; 2001 Apr 13; 494(3):192-5. PubMed ID: 11311239
    [Abstract] [Full Text] [Related]

  • 15. Aggrecanases and cartilage matrix degradation.
    Nagase H, Kashiwagi M.
    Arthritis Res Ther; 2003 Apr 13; 5(2):94-103. PubMed ID: 12718749
    [Abstract] [Full Text] [Related]

  • 16. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
    Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD.
    Osteoarthritis Cartilage; 2005 Apr 13; 13(4):269-77. PubMed ID: 15780640
    [Abstract] [Full Text] [Related]

  • 17. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
    Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman MC, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Burn TC.
    J Biol Chem; 1999 Aug 13; 274(33):23443-50. PubMed ID: 10438522
    [Abstract] [Full Text] [Related]

  • 18. Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373-Ala374.
    Frank JE, Thompson VP, Brown MP, Sandy JD.
    Osteoarthritis Cartilage; 2009 Jun 13; 17(6):777-81. PubMed ID: 19071032
    [Abstract] [Full Text] [Related]

  • 19. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
    Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, Zimmermann DR, Lemire JM, Fischer JW, Wight TN, Clowes AW.
    J Biol Chem; 2001 Apr 20; 276(16):13372-8. PubMed ID: 11278559
    [Abstract] [Full Text] [Related]

  • 20. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
    Tortorella MD, Liu RQ, Burn T, Newton RC, Arner E.
    Matrix Biol; 2002 Oct 20; 21(6):499-511. PubMed ID: 12392761
    [Abstract] [Full Text] [Related]

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