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Journal Abstract Search

267 related items for PubMed ID: 11884127

  • 1. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.
    J Mol Biol; 2002 Mar 01; 316(4):869-74. PubMed ID: 11884127
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  • 2. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 01; 17(3):252-65. PubMed ID: 8272424
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  • 3. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
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  • 4. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
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  • 6. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.
    Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ.
    J Mol Biol; 2001 Aug 17; 311(3):549-55. PubMed ID: 11493008
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  • 7. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 17; 7(2):243-53. PubMed ID: 9521099
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  • 9. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
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  • 10. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 13. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 24; 5(6):1174-83. PubMed ID: 8762149
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  • 14. Potent bivalent thrombin inhibitors: replacement of the scissile peptide bond at P(1)-P(1)' with arginyl ketomethylene isosteres.
    Steinmetzer T, Zhu BY, Konishi Y.
    J Med Chem; 1999 Aug 12; 42(16):3109-15. PubMed ID: 10447955
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  • 15. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.
    Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.
    Biochemistry; 1999 Jun 22; 38(25):7969-77. PubMed ID: 10387040
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  • 17. The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.
    Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1999 Jan 22; 8(1):91-5. PubMed ID: 10210187
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  • 18. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
    Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD.
    Biochemistry; 1996 Mar 12; 35(10):3147-55. PubMed ID: 8605148
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  • 19. The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
    van de Locht A, Stubbs MT, Bode W, Friedrich T, Bollschweiler C, Höffken W, Huber R.
    EMBO J; 1996 Nov 15; 15(22):6011-7. PubMed ID: 8947023
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