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Journal Abstract Search

126 related items for PubMed ID: 11899248

  • 1. Discovery of the factor Xa inhibitor, ZK 807834 (CI-1031).
    Light DR, Guilford WJ.
    Curr Top Med Chem; 2001 Jun; 1(2):121-36. PubMed ID: 11899248
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  • 3. Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.
    Wiley MR, Weir LC, Briggs S, Bryan NA, Buben J, Campbell C, Chirgadze NY, Conrad RC, Craft TJ, Ficorilli JV, Franciskovich JB, Froelich LL, Gifford-Moore DS, Goodson T, Herron DK, Klimkowski VJ, Kurz KD, Kyle JA, Masters JJ, Ratz AM, Milot G, Shuman RT, Smith T, Smith GF, Tebbe AL, Tinsley JM.
    J Med Chem; 2000 Mar 09; 43(5):883-99. PubMed ID: 10715155
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  • 5. Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.
    Adler M, Davey DD, Phillips GB, Kim SH, Jancarik J, Rumennik G, Light DR, Whitlow M.
    Biochemistry; 2000 Oct 17; 39(41):12534-42. PubMed ID: 11027132
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  • 7. Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors.
    Maduskuie TP, McNamara KJ, Ru Y, Knabb RM, Stouten PF.
    J Med Chem; 1998 Jan 01; 41(1):53-62. PubMed ID: 9438022
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  • 8. Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
    Phillips G, Guilford WJ, Buckman BO, Davey DD, Eagen KA, Koovakkat S, Liang A, McCarrick M, Mohan R, Ng HP, Pinkerton M, Subramanyam B, Ho E, Trinh L, Whitlow M, Wu S, Xu W, Morrissey MM.
    J Med Chem; 2002 Jun 06; 45(12):2484-93. PubMed ID: 12036356
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  • 9. Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
    Phillips G, Davey DD, Eagen KA, Koovakkat SK, Liang A, Ng HP, Pinkerton M, Trinh L, Whitlow M, Beatty AM, Morrissey MM.
    J Med Chem; 1999 May 20; 42(10):1749-56. PubMed ID: 10346927
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  • 10. Discovery of R-142086 as a factor Xa (FXa) inhibitor: syntheses and structure-activity relationships of cinnamyl derivatives.
    Noguchi T, Tanaka N, Nishimata T, Goto R, Hayakawa M, Sugidachi A, Ogawa T, Niitsu Y, Asai F, Ishizuka T, Fujimoto K.
    Chem Pharm Bull (Tokyo); 2009 Jan 20; 57(1):22-33. PubMed ID: 19122312
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  • 12. Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors.
    Dudley DA, Bunker AM, Chi L, Cody WL, Holland DR, Ignasiak DP, Janiczek-Dolphin N, McClanahan TB, Mertz TE, Narasimhan LS, Rapundalo ST, Trautschold JA, Van Huis CA, Edmunds JJ.
    J Med Chem; 2000 Nov 02; 43(22):4063-70. PubMed ID: 11063603
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  • 14. Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors.
    Han Q, Dominguez C, Stouten PF, Park JM, Duffy DE, Galemmo RA, Rossi KA, Alexander RS, Smallwood AM, Wong PC, Wright MM, Luettgen JM, Knabb RM, Wexler RR.
    J Med Chem; 2000 Nov 16; 43(23):4398-415. PubMed ID: 11087565
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  • 15. Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.
    Guertin KR, Gardner CJ, Klein SI, Zulli AL, Czekaj M, Gong Y, Spada AP, Cheney DL, Maignan S, Guilloteau JP, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Dunwiddie CT, Leadley RJ, Pauls HW.
    Bioorg Med Chem Lett; 2002 Jun 17; 12(12):1671-4. PubMed ID: 12039587
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  • 16. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 17. Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.
    Sagi K, Nakagawa T, Yamanashi M, Makino S, Takahashi M, Takayanagi M, Takenaka K, Suzuki N, Oono S, Kataoka N, Ishikawa K, Shima S, Fukuda Y, Kayahara T, Takehana S, Shima Y, Tashiro K, Yamamoto H, Yoshimoto R, Iwata S, Tsuji T, Sakurai K, Shoji M.
    J Med Chem; 2003 May 08; 46(10):1845-57. PubMed ID: 12723948
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