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Journal Abstract Search

176 related items for PubMed ID: 11918801

  • 1. Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei.
    Shahi SK, Krauth-Siegel RL, Clayton CE.
    Mol Microbiol; 2002 Mar; 43(5):1129-38. PubMed ID: 11918801
    [Abstract] [Full Text] [Related]

  • 2. The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
    Alibu VP, Richter C, Voncken F, Marti G, Shahi S, Renggli CK, Seebeck T, Brun R, Clayton C.
    Mol Biochem Parasitol; 2006 Mar; 146(1):38-44. PubMed ID: 16343658
    [Abstract] [Full Text] [Related]

  • 3. Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.
    Fairlamb AH, Carter NS, Cunningham M, Smith K.
    Mol Biochem Parasitol; 1992 Jul; 53(1-2):213-22. PubMed ID: 1501641
    [Abstract] [Full Text] [Related]

  • 4. Combined contribution of TbAT1 and TbMRPA to drug resistance in Trypanosoma brucei.
    Lüscher A, Nerima B, Mäser P.
    Mol Biochem Parasitol; 2006 Dec; 150(2):364-6. PubMed ID: 16935360
    [No Abstract] [Full Text] [Related]

  • 5. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
    Ariyanayagam MR, Oza SL, Guther ML, Fairlamb AH.
    Biochem J; 2005 Oct 15; 391(Pt 2):425-32. PubMed ID: 16008527
    [Abstract] [Full Text] [Related]

  • 6. Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
    Huynh TT, Huynh VT, Harmon MA, Phillips MA.
    J Biol Chem; 2003 Oct 10; 278(41):39794-800. PubMed ID: 12888552
    [Abstract] [Full Text] [Related]

  • 7. Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.
    Mukherjee A, Padmanabhan PK, Singh S, Roy G, Girard I, Chatterjee M, Ouellette M, Madhubala R.
    J Antimicrob Chemother; 2007 Feb 10; 59(2):204-11. PubMed ID: 17213267
    [Abstract] [Full Text] [Related]

  • 8. A Trypanosoma brucei ORFeome-Based Gain-of-Function Library Identifies Genes That Promote Survival during Melarsoprol Treatment.
    Carter M, Gomez S, Gritz S, Larson S, Silva-Herzog E, Kim HS, Schulz D, Hovel-Miner G.
    mSphere; 2020 Oct 07; 5(5):. PubMed ID: 33028684
    [Abstract] [Full Text] [Related]

  • 9. A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes.
    Ebersoll S, Bogacz M, Günter LM, Dick TP, Krauth-Siegel RL.
    Elife; 2020 Jan 31; 9():. PubMed ID: 32003744
    [Abstract] [Full Text] [Related]

  • 10. Drug transport and drug resistance in African trypanosomes.
    Mäser P, Lüscher A, Kaminsky R.
    Drug Resist Updat; 2003 Oct 31; 6(5):281-90. PubMed ID: 14643298
    [Abstract] [Full Text] [Related]

  • 11. RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
    Xiao Y, McCloskey DE, Phillips MA.
    Eukaryot Cell; 2009 May 31; 8(5):747-55. PubMed ID: 19304951
    [Abstract] [Full Text] [Related]

  • 12. Trypanothione is the primary target for arsenical drugs against African trypanosomes.
    Fairlamb AH, Henderson GB, Cerami A.
    Proc Natl Acad Sci U S A; 1989 Apr 31; 86(8):2607-11. PubMed ID: 2704738
    [Abstract] [Full Text] [Related]

  • 13. Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
    Stewart ML, Krishna S, Burchmore RJ, Brun R, de Koning HP, Boykin DW, Tidwell RR, Hall JE, Barrett MP.
    Lancet; 1989 Apr 31; 366(9484):486-7. PubMed ID: 16084257
    [Abstract] [Full Text] [Related]

  • 14. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
    González-Chávez Z, Vázquez C, Mejia-Tlachi M, Márquez-Dueñas C, Manning-Cela R, Encalada R, Rodríguez-Enríquez S, Michels PAM, Moreno-Sánchez R, Saavedra E.
    Redox Biol; 2019 Sep 31; 26():101231. PubMed ID: 31203195
    [Abstract] [Full Text] [Related]

  • 15. Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
    Yarlett N, Goldberg B, Nathan HC, Garofalo J, Bacchi CJ.
    Exp Parasitol; 1991 Feb 31; 72(2):205-15. PubMed ID: 1849084
    [Abstract] [Full Text] [Related]

  • 16. Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.
    König J, Wyllie S, Wells G, Stevens MF, Wyatt PG, Fairlamb AH.
    J Biol Chem; 2011 Mar 11; 286(10):8523-8533. PubMed ID: 21212280
    [Abstract] [Full Text] [Related]

  • 17. Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
    Alghamdi AH, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, Smart G, Anderson LF, Woodley CM, Kelly SPY, Ibrahim HM, Hulpia F, Al-Salabi MI, Eze AA, Sprenger T, Teka IA, Gudin S, Weyand S, Field M, Dardonville C, Tidwell RR, Carrington M, O'Neill P, Boykin DW, Zachariae U, De Koning HP.
    Elife; 2020 Aug 11; 9():. PubMed ID: 32762841
    [Abstract] [Full Text] [Related]

  • 18. Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
    de Koning HP, MacLeod A, Barrett MP, Cover B, Jarvis SM.
    Mol Biochem Parasitol; 2000 Feb 25; 106(1):181-5. PubMed ID: 10743623
    [No Abstract] [Full Text] [Related]

  • 19. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
    Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, Mäser P.
    Cell Mol Life Sci; 2016 Sep 25; 73(17):3387-400. PubMed ID: 26973180
    [Abstract] [Full Text] [Related]

  • 20. High-throughput decoding of antitrypanosomal drug efficacy and resistance.
    Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berriman M, Horn D.
    Nature; 2012 Jan 25; 482(7384):232-6. PubMed ID: 22278056
    [Abstract] [Full Text] [Related]

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