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150 related items for PubMed ID: 11923470

  • 1. Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
    Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S.
    Mol Endocrinol; 2002 Apr; 16(4):736-46. PubMed ID: 11923470
    [Abstract] [Full Text] [Related]

  • 2. Effects of mutations involving the highly conserved S281HCC motif in the extracellular domain of the thyrotropin (TSH) receptor on TSH binding and constitutive activity.
    Ho SC, Van Sande J, Lefort A, Vassart G, Costagliola S.
    Endocrinology; 2001 Jul; 142(7):2760-7. PubMed ID: 11415994
    [Abstract] [Full Text] [Related]

  • 3. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
    Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD.
    Mol Endocrinol; 1993 Aug; 7(8):1009-20. PubMed ID: 7901757
    [Abstract] [Full Text] [Related]

  • 4. Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
    Neumann S, Claus M, Paschke R.
    Eur J Endocrinol; 2005 Apr; 152(4):625-34. PubMed ID: 15817920
    [Abstract] [Full Text] [Related]

  • 5. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.
    Kosugi S, Kohn LD, Akamizu T, Mori T.
    Mol Endocrinol; 1994 Apr; 8(4):498-509. PubMed ID: 7914349
    [Abstract] [Full Text] [Related]

  • 6. Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.
    Parma J, Van Sande J, Swillens S, Tonacchera M, Dumont J, Vassart G.
    Mol Endocrinol; 1995 Jun; 9(6):725-33. PubMed ID: 8592518
    [Abstract] [Full Text] [Related]

  • 7. A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
    Neumann S, Krause G, Chey S, Paschke R.
    Mol Endocrinol; 2001 Aug; 15(8):1294-305. PubMed ID: 11463854
    [Abstract] [Full Text] [Related]

  • 8. Signal transduction by the human thyrotropin receptor: studies on the role of individual amino acid residues in the carboxyl terminal region of the third cytoplasmic loop.
    Chazenbalk GD, Nagayama Y, Wadsworth H, Russo D, Rapoport B.
    Mol Endocrinol; 1991 Oct; 5(10):1523-6. PubMed ID: 1663578
    [Abstract] [Full Text] [Related]

  • 9. The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
    Gu WX, Du GG, Kopp P, Rentoumis A, Albanese C, Kohn LD, Madison LD, Jameson JL.
    Endocrinology; 1995 Jul; 136(7):3146-53. PubMed ID: 7789342
    [Abstract] [Full Text] [Related]

  • 10. On the functional importance of thyrotropin receptor intramolecular cleavage.
    Chazenbalk GD, Tanaka K, McLachlan SM, Rapoport B.
    Endocrinology; 1999 Oct; 140(10):4516-20. PubMed ID: 10499506
    [Abstract] [Full Text] [Related]

  • 11. The hinge region of the TSH receptor stabilizes ligand binding and determines different signaling profiles of human and bovine TSH.
    Jaeschke H, Schaarschmidt J, Günther R, Mueller S.
    Endocrinology; 2011 Oct; 152(10):3986-96. PubMed ID: 21846801
    [Abstract] [Full Text] [Related]

  • 12. Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity.
    Ho SC, Goh SS, Su Q, Khoo DH.
    Mol Cell Endocrinol; 2005 Dec 21; 245(1-2):158-68. PubMed ID: 16364538
    [Abstract] [Full Text] [Related]

  • 13. Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling.
    Alvarez CA, Narayan P, Huang J, Puett D.
    Endocrinology; 1999 Apr 21; 140(4):1775-82. PubMed ID: 10098515
    [Abstract] [Full Text] [Related]

  • 14. Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction.
    Nagayama Y, Rapoport B.
    Endocrinology; 1992 Aug 21; 131(2):548-52. PubMed ID: 1322272
    [Abstract] [Full Text] [Related]

  • 15. Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist.
    Frändberg PA, Doufexis M, Kapas S, Chhajlani V.
    Biochem Biophys Res Commun; 2001 Mar 09; 281(4):851-7. PubMed ID: 11237737
    [Abstract] [Full Text] [Related]

  • 16. The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells.
    Kudo M, Chen T, Nakabayashi K, Hsu SY, Hsueh AJ.
    Mol Endocrinol; 2000 Feb 09; 14(2):272-84. PubMed ID: 10674399
    [Abstract] [Full Text] [Related]

  • 17. Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.
    Paschke R, Tonacchera M, Van Sande J, Parma J, Vassart G.
    J Clin Endocrinol Metab; 1994 Dec 09; 79(6):1785-9. PubMed ID: 7989485
    [Abstract] [Full Text] [Related]

  • 18. An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
    Jaeschke H, Neumann S, Kleinau G, Mueller S, Claus M, Krause G, Paschke R.
    Endocrinology; 2006 Apr 09; 147(4):1753-60. PubMed ID: 16410307
    [Abstract] [Full Text] [Related]

  • 19. Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor.
    Kosugi S, Shenker A, Mori T.
    FEBS Lett; 1994 Dec 19; 356(2-3):291-4. PubMed ID: 7805857
    [Abstract] [Full Text] [Related]

  • 20. Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas.
    Porcellini A, Ciullo I, Pannain S, Fenzi G, Avvedimento E.
    Oncogene; 1995 Sep 21; 11(6):1089-93. PubMed ID: 7566968
    [Abstract] [Full Text] [Related]

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