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522 related items for PubMed ID: 11940647

  • 1. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
    Kwak MK, Itoh K, Yamamoto M, Kensler TW.
    Mol Cell Biol; 2002 May; 22(9):2883-92. PubMed ID: 11940647
    [Abstract] [Full Text] [Related]

  • 2. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
    Kwak MK, Itoh K, Yamamoto M, Sutter TR, Kensler TW.
    Mol Med; 2001 Feb; 7(2):135-45. PubMed ID: 11471548
    [Abstract] [Full Text] [Related]

  • 3. Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
    Pietsch EC, Chan JY, Torti FM, Torti SV.
    J Biol Chem; 2003 Jan 24; 278(4):2361-9. PubMed ID: 12435735
    [Abstract] [Full Text] [Related]

  • 4. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
    Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK.
    Eur J Pharmacol; 2007 Dec 22; 577(1-3):17-27. PubMed ID: 17854798
    [Abstract] [Full Text] [Related]

  • 5. Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway.
    Wang L, Wang M, Hu J, Shen W, Hu J, Yao Y, Wang X, Afzal CM, Ma R, Li G.
    Eur J Pharmacol; 2017 Jan 15; 795():115-123. PubMed ID: 27939991
    [Abstract] [Full Text] [Related]

  • 6. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury.
    Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y.
    FEBS Lett; 2005 Jun 06; 579(14):3029-36. PubMed ID: 15896789
    [Abstract] [Full Text] [Related]

  • 7. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.
    Dhakshinamoorthy S, Jain AK, Bloom DA, Jaiswal AK.
    J Biol Chem; 2005 Apr 29; 280(17):16891-900. PubMed ID: 15734732
    [Abstract] [Full Text] [Related]

  • 8. Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes.
    Miao W, Hu L, Scrivens PJ, Batist G.
    J Biol Chem; 2005 May 27; 280(21):20340-8. PubMed ID: 15790560
    [Abstract] [Full Text] [Related]

  • 9. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway.
    Kwak MK, Wakabayashi N, Greenlaw JL, Yamamoto M, Kensler TW.
    Mol Cell Biol; 2003 Dec 27; 23(23):8786-94. PubMed ID: 14612418
    [Abstract] [Full Text] [Related]

  • 10. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.
    Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW.
    J Biol Chem; 2003 Mar 07; 278(10):8135-45. PubMed ID: 12506115
    [Abstract] [Full Text] [Related]

  • 11. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
    McMahon M, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2003 Jun 13; 278(24):21592-600. PubMed ID: 12682069
    [Abstract] [Full Text] [Related]

  • 12. Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo.
    Otieno MA, Kensler TW, Guyton KZ.
    Free Radic Biol Med; 2000 Mar 15; 28(6):944-52. PubMed ID: 10802226
    [Abstract] [Full Text] [Related]

  • 13. Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.
    Arinze IJ, Kawai Y.
    J Biol Chem; 2005 Mar 18; 280(11):9786-95. PubMed ID: 15640523
    [Abstract] [Full Text] [Related]

  • 14. Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
    Bloom D, Dhakshinamoorthy S, Jaiswal AK.
    Oncogene; 2002 Mar 28; 21(14):2191-200. PubMed ID: 11948402
    [Abstract] [Full Text] [Related]

  • 15. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).
    Keum YS, Owuor ED, Kim BR, Hu R, Kong AN.
    Pharm Res; 2003 Sep 28; 20(9):1351-6. PubMed ID: 14567627
    [Abstract] [Full Text] [Related]

  • 16. Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression.
    Kaspar JW, Jaiswal AK.
    J Biol Chem; 2010 Jan 01; 285(1):153-62. PubMed ID: 19897490
    [Abstract] [Full Text] [Related]

  • 17. Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
    Soriano FX, Léveillé F, Papadia S, Higgins LG, Varley J, Baxter P, Hayes JD, Hardingham GE.
    J Neurochem; 2008 Oct 01; 107(2):533-43. PubMed ID: 18761713
    [Abstract] [Full Text] [Related]

  • 18. Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene.
    Vollrath V, Wielandt AM, Iruretagoyena M, Chianale J.
    Biochem J; 2006 May 01; 395(3):599-609. PubMed ID: 16426233
    [Abstract] [Full Text] [Related]

  • 19. Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway.
    Park HM, Cho JM, Lee HR, Shim GS, Kwak MK.
    Biochem Pharmacol; 2008 Sep 01; 76(5):597-607. PubMed ID: 18656455
    [Abstract] [Full Text] [Related]

  • 20. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression.
    Bloom DA, Jaiswal AK.
    J Biol Chem; 2003 Nov 07; 278(45):44675-82. PubMed ID: 12947090
    [Abstract] [Full Text] [Related]

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