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136 related items for PubMed ID: 11955525

  • 1. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats.
    Scarpace PJ, Matheny M, Zhang Y, Tümer N, Frase CD, Shek EW, Hong B, Prima V, Zolotukhin S.
    Neuropharmacology; 2002 Mar; 42(4):548-61. PubMed ID: 11955525
    [Abstract] [Full Text] [Related]

  • 2. Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats.
    Shek EW, Scarpace PJ.
    Regul Pept; 2000 Aug 25; 92(1-3):65-71. PubMed ID: 11024567
    [Abstract] [Full Text] [Related]

  • 3. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.
    Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS.
    Regul Pept; 2001 Jun 15; 99(2-3):69-77. PubMed ID: 11384767
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  • 4. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance.
    Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tümer N.
    Endocrinology; 2002 Aug 15; 143(8):3026-35. PubMed ID: 12130569
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  • 6. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.
    Scarpace PJ, Matheny M, Tümer N, Cheng KY, Zhang Y.
    Diabetologia; 2005 Jun 15; 48(6):1075-83. PubMed ID: 15864530
    [Abstract] [Full Text] [Related]

  • 7. Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity.
    Wilsey J, Zolotukhin S, Prima V, Scarpace PJ.
    Am J Physiol Regul Integr Comp Physiol; 2003 Nov 15; 285(5):R1011-20. PubMed ID: 14557234
    [Abstract] [Full Text] [Related]

  • 8. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats.
    Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ.
    Neuroscience; 2002 Nov 15; 115(3):879-89. PubMed ID: 12435426
    [Abstract] [Full Text] [Related]

  • 9. The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.
    Zhang J, Scarpace PJ.
    Br J Pharmacol; 2009 Sep 15; 158(2):475-82. PubMed ID: 19422379
    [Abstract] [Full Text] [Related]

  • 10. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats.
    Scarpace PJ, Matheny M, Tümer N.
    Neuroscience; 2001 Sep 15; 104(4):1111-7. PubMed ID: 11457594
    [Abstract] [Full Text] [Related]

  • 11. Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels.
    Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP.
    Diabetes; 2002 Jun 15; 51(6):1729-36. PubMed ID: 12031959
    [Abstract] [Full Text] [Related]

  • 12. iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery.
    Côté I, Sakarya Y, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ.
    Am J Physiol Endocrinol Metab; 2018 Mar 01; 314(3):E224-E231. PubMed ID: 29089334
    [Abstract] [Full Text] [Related]

  • 13. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.
    Li G, Mobbs CV, Scarpace PJ.
    Diabetes; 2003 Aug 01; 52(8):1951-7. PubMed ID: 12882910
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  • 15. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.
    Zhang J, Matheny MK, Tümer N, Mitchell MK, Scarpace PJ.
    Am J Physiol Regul Integr Comp Physiol; 2007 Feb 01; 292(2):R868-74. PubMed ID: 17023670
    [Abstract] [Full Text] [Related]

  • 16. Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness.
    Li G, Zhang Y, Cheng KY, Scarpace PJ.
    Diabetologia; 2007 Jul 01; 50(7):1490-9. PubMed ID: 17505816
    [Abstract] [Full Text] [Related]

  • 17. Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin.
    Bagnasco M, Dube MG, Katz A, Kalra PS, Kalra SP.
    Obes Res; 2003 Dec 01; 11(12):1463-70. PubMed ID: 14694210
    [Abstract] [Full Text] [Related]

  • 18. Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.
    Scarpace PJ, Matheny M, Zhang Y, Cheng KY, Tümer N.
    J Pharmacol Exp Ther; 2007 Feb 01; 320(2):706-12. PubMed ID: 17082312
    [Abstract] [Full Text] [Related]

  • 19. Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes.
    Beretta E, Dube MG, Kalra PS, Kalra SP.
    Pediatr Res; 2002 Aug 01; 52(2):189-98. PubMed ID: 12149495
    [Abstract] [Full Text] [Related]

  • 20. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus.
    Dhillon H, Kalra SP, Kalra PS.
    Mol Ther; 2001 Aug 01; 4(2):139-45. PubMed ID: 11482985
    [Abstract] [Full Text] [Related]

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