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Journal Abstract Search

134 related items for PubMed ID: 11972752

  • 1.
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  • 2. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.
    Wang B, Nimkar K, Wang W, Zhang H, Shan D, Gudmundsson O, Gangwar S, Siahaan T, Borchardt RT.
    J Pept Res; 1999 Apr; 53(4):370-82. PubMed ID: 10406215
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  • 4. A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
    Ouyang H, Tang F, Siahaan TJ, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):794-801. PubMed ID: 12134949
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  • 5. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.
    Bak A, Siahaan TJ, Gudmundsson OS, Gangwar S, Friis GJ, Borchardt RT.
    J Pept Res; 1999 Apr; 53(4):393-402. PubMed ID: 10406217
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  • 9. Optimizing oral absorption of peptides using prodrug strategies.
    Borchardt RT.
    J Control Release; 1999 Nov 01; 62(1-2):231-8. PubMed ID: 10518655
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  • 10. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM, Borchardt RT.
    J Pharm Sci; 2005 Oct 01; 94(10):2198-206. PubMed ID: 16136552
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  • 11. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT.
    Pharm Res; 1999 Jan 01; 16(1):16-23. PubMed ID: 9950273
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  • 12. The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.
    Gudmundsson OS, Jois SD, Vander Velde DG, Siahaan TJ, Wang B, Borchardt RT.
    J Pept Res; 1999 Apr 01; 53(4):383-92. PubMed ID: 10406216
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  • 13. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A, Gudmundsson OS, Friis GJ, Siahaan TJ, Borchardt RT.
    Pharm Res; 1999 Jan 01; 16(1):24-9. PubMed ID: 9950274
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  • 14. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa.
    Nofsinger R, Borchardt RT.
    J Pharm Sci; 2012 Sep 01; 101(9):3500-10. PubMed ID: 22337204
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  • 15. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.
    Gudmundsson OS, Pauletti GM, Wang W, Shan D, Zhang H, Wang B, Borchardt RT.
    Pharm Res; 1999 Jan 01; 16(1):7-15. PubMed ID: 9950272
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  • 16. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun 01; 19(6):787-93. PubMed ID: 12134948
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  • 17. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide.
    Pauletti GM, Gangwar S, Okumu FW, Siahaan TJ, Stella VJ, Borchardt RT.
    Pharm Res; 1996 Nov 01; 13(11):1615-23. PubMed ID: 8956324
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  • 18. The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties.
    Zych LA, Yang W, Liao Y, Griffin KR, Wang B.
    Bioorg Chem; 2004 Apr 01; 32(2):109-23. PubMed ID: 14990309
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  • 19. Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan 01; 98(1):349-61. PubMed ID: 18537150
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  • 20. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism.
    Nofsinger R, Fuchs-Knotts T, Borchardt RT.
    J Pharm Sci; 2012 Sep 01; 101(9):3486-99. PubMed ID: 22411763
    [Abstract] [Full Text] [Related]

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