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166 related items for PubMed ID: 11994273

  • 1. TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
    Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR, Walmsley AR, Wakelam MJ, Warwicker J, Houslay MD.
    J Biol Chem; 2002 Aug 02; 277(31):28298-309. PubMed ID: 11994273
    [Abstract] [Full Text] [Related]

  • 2. Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.
    Huston E, Gall I, Houslay TM, Houslay MD.
    J Cell Sci; 2006 Sep 15; 119(Pt 18):3799-810. PubMed ID: 16940352
    [Abstract] [Full Text] [Related]

  • 3. Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.
    Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.
    Cell Signal; 2001 Apr 15; 13(4):287-97. PubMed ID: 11306246
    [Abstract] [Full Text] [Related]

  • 4. Regulation of cAMP-phosphodiesterases by phosphatidic acid binding.
    Grange M, Sette C, Prigent AF, Lagarde M, Némoz G.
    Lipids; 1999 Apr 15; 34 Suppl():S83. PubMed ID: 10419099
    [No Abstract] [Full Text] [Related]

  • 5. cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
    Huston E, Houslay TM, Baillie GS, Houslay MD.
    Biochem Soc Trans; 2006 Aug 15; 34(Pt 4):504-9. PubMed ID: 16856845
    [Abstract] [Full Text] [Related]

  • 6. The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site.
    Grange M, Sette C, Cuomo M, Conti M, Lagarde M, Prigent AF, Némoz G.
    J Biol Chem; 2000 Oct 27; 275(43):33379-87. PubMed ID: 10938092
    [Abstract] [Full Text] [Related]

  • 7. UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.
    Beard MB, Olsen AE, Jones RE, Erdogan S, Houslay MD, Bolger GB.
    J Biol Chem; 2000 Apr 07; 275(14):10349-58. PubMed ID: 10744723
    [Abstract] [Full Text] [Related]

  • 8. Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.
    Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.
    J Biol Chem; 2000 Dec 08; 275(49):38749-61. PubMed ID: 10952971
    [Abstract] [Full Text] [Related]

  • 9. Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B.
    Zhang W, Ke H, Tretiakova AP, Jameson B, Colman RW.
    Protein Sci; 2001 Aug 08; 10(8):1481-9. PubMed ID: 11468344
    [Abstract] [Full Text] [Related]

  • 10. Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.
    Scotland G, Houslay MD.
    Biochem J; 1995 Jun 01; 308 ( Pt 2)(Pt 2):673-81. PubMed ID: 7772057
    [Abstract] [Full Text] [Related]

  • 11. In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.
    Beard MB, Huston E, Campbell L, Gall I, McPhee I, Yarwood S, Scotland G, Houslay MD.
    Cell Signal; 2002 May 01; 14(5):453-65. PubMed ID: 11882390
    [Abstract] [Full Text] [Related]

  • 12. Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs.
    Smith KJ, Scotland G, Beattie J, Trayer IP, Houslay MD.
    J Biol Chem; 1996 Jul 12; 271(28):16703-11. PubMed ID: 8663181
    [Abstract] [Full Text] [Related]

  • 13. The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
    Richter W, Conti M.
    J Biol Chem; 2004 Jul 16; 279(29):30338-48. PubMed ID: 15131123
    [Abstract] [Full Text] [Related]

  • 14. Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.
    He Q, Wang F, Liu S, Zhu D, Cong H, Gao F, Li B, Wang H, Lin Z, Liao J, Gu L.
    J Biol Chem; 2016 Feb 12; 291(7):3668-81. PubMed ID: 26668313
    [Abstract] [Full Text] [Related]

  • 15. The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution.
    Huston E, Beard M, McCallum F, Pyne NJ, Vandenabeele P, Scotland G, Houslay MD.
    J Biol Chem; 2000 Sep 08; 275(36):28063-74. PubMed ID: 10829034
    [Abstract] [Full Text] [Related]

  • 16. Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
    Johnston LA, Erdogan S, Cheung YF, Sullivan M, Barber R, Lynch MJ, Baillie GS, Van Heeke G, Adams DR, Huston E, Houslay MD.
    Biochem J; 2004 Jun 01; 380(Pt 2):371-84. PubMed ID: 15025561
    [Abstract] [Full Text] [Related]

  • 17. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
    Houslay MD, Adams DR.
    Biochem J; 2003 Feb 15; 370(Pt 1):1-18. PubMed ID: 12444918
    [Abstract] [Full Text] [Related]

  • 18. Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
    Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD.
    Cell Signal; 2003 Oct 15; 15(10):955-71. PubMed ID: 12873709
    [Abstract] [Full Text] [Related]

  • 19. Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
    Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD.
    J Biol Chem; 2003 Aug 29; 278(35):33351-63. PubMed ID: 12810716
    [Abstract] [Full Text] [Related]

  • 20. The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).
    O'Connell JC, McCallum JF, McPhee I, Wakefield J, Houslay ES, Wishart W, Bolger G, Frame M, Houslay MD.
    Biochem J; 1996 Aug 15; 318 ( Pt 1)(Pt 1):255-61. PubMed ID: 8761480
    [Abstract] [Full Text] [Related]

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