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486 related items for PubMed ID: 12021625

  • 1. Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
    Pettersson B, Almer S, Albertioni F, Söderhäll S, Peterson C.
    Ther Drug Monit; 2002 Jun; 24(3):351-8. PubMed ID: 12021625
    [Abstract] [Full Text] [Related]

  • 2. Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
    Dervieux T, Meyer G, Barham R, Matsutani M, Barry M, Boulieu R, Neri B, Seidman E.
    Clin Chem; 2005 Nov; 51(11):2074-84. PubMed ID: 16166171
    [Abstract] [Full Text] [Related]

  • 3. The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients.
    Wong DR, Pierik M, Seinen ML, van Bodegraven AA, Gilissen LP, Bus P, Bakker JA, Masclee AA, Neef C, Engels LG, Hooymans PM.
    J Crohns Colitis; 2014 Feb; 8(2):120-8. PubMed ID: 23932783
    [Abstract] [Full Text] [Related]

  • 4. IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.
    Haglund S, Taipalensuu J, Peterson C, Almer S.
    Br J Clin Pharmacol; 2008 Jan; 65(1):69-77. PubMed ID: 17662091
    [Abstract] [Full Text] [Related]

  • 5. Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
    Kwan LY, Devlin SM, Mirocha JM, Papadakis KA.
    Dig Liver Dis; 2008 Jun; 40(6):425-32. PubMed ID: 18304898
    [Abstract] [Full Text] [Related]

  • 6. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
    Relling MV, Hancock ML, Rivera GK, Sandlund JT, Ribeiro RC, Krynetski EY, Pui CH, Evans WE.
    J Natl Cancer Inst; 1999 Dec 01; 91(23):2001-8. PubMed ID: 10580024
    [Abstract] [Full Text] [Related]

  • 7. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
    Gearry RB, Barclay ML.
    J Gastroenterol Hepatol; 2005 Aug 01; 20(8):1149-57. PubMed ID: 16048561
    [Abstract] [Full Text] [Related]

  • 8. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
    Lennard L, Welch JC, Lilleyman JS.
    Br J Clin Pharmacol; 1997 Nov 01; 44(5):455-61. PubMed ID: 9384462
    [Abstract] [Full Text] [Related]

  • 9. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
    Hawwa AF, Millership JS, Collier PS, Vandenbroeck K, McCarthy A, Dempsey S, Cairns C, Collins J, Rodgers C, McElnay JC.
    Br J Clin Pharmacol; 2008 Oct 01; 66(4):517-28. PubMed ID: 18662289
    [Abstract] [Full Text] [Related]

  • 10. Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
    Lennard L, Cartwright CS, Wade R, Richards SM, Vora A.
    Br J Clin Pharmacol; 2013 Jul 01; 76(1):125-36. PubMed ID: 23252716
    [Abstract] [Full Text] [Related]

  • 11. Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.
    Vikingsson S, Andersson D, Almer S, Peterson C, Hindorf U.
    J Crohns Colitis; 2014 Dec 01; 8(12):1702-9. PubMed ID: 25239576
    [Abstract] [Full Text] [Related]

  • 12. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
    Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM.
    Clin Pharmacol Ther; 1987 Jan 01; 41(1):18-25. PubMed ID: 3467886
    [Abstract] [Full Text] [Related]

  • 13. ITPA Activity in Adults and Children Treated With or Without Azathioprine: Relationship Between TPMT Activity, Thiopurine Metabolites, and Co-medications.
    Citterio-Quentin A, Moulsma M, Gustin MP, Boulieu R.
    Ther Drug Monit; 2017 Oct 01; 39(5):483-491. PubMed ID: 28650902
    [Abstract] [Full Text] [Related]

  • 14. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia.
    Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM.
    Lancet; 1990 Jul 28; 336(8709):225-9. PubMed ID: 1973780
    [Abstract] [Full Text] [Related]

  • 15. The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.
    Haglund S, Vikingsson S, Söderman J, Hindorf U, Grännö C, Danelius M, Coulthard S, Peterson C, Almer S.
    Ther Drug Monit; 2011 Apr 28; 33(2):200-8. PubMed ID: 21311411
    [Abstract] [Full Text] [Related]

  • 16. Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.
    González-Lama Y, Bermejo F, López-Sanromán A, García-Sánchez V, Esteve M, Cabriada JL, McNicholl AG, Pajares R, Casellas F, Merino O, Carpio D, Vera MI, Muñoz C, Calvo M, Benito LM, Bujanda L, García-Fernández FJ, Ricart E, Ginard D, Velasco M, Carneros JA, Manceñido N, Calvo M, Algaba A, Froilan C, Cara C, Maté J, Abreu L, Gisbert JP, "Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU)".
    Aliment Pharmacol Ther; 2011 Sep 28; 34(5):544-54. PubMed ID: 21722149
    [Abstract] [Full Text] [Related]

  • 17. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.
    Lowry PW, Franklin CL, Weaver AL, Pike MG, Mays DC, Tremaine WJ, Lipsky JJ, Sandborn WJ.
    Gut; 2001 Nov 28; 49(5):665-70. PubMed ID: 11600469
    [Abstract] [Full Text] [Related]

  • 18. Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
    Levinsen M, Rosthøj S, Nygaard U, Heldrup J, Harila-Saari A, Jonsson OG, Bechensteen AG, Abrahamsson J, Lausen B, Frandsen TL, Weinshilboum RM, Schmiegelow K.
    Cancer Chemother Pharmacol; 2015 Jan 28; 75(1):59-66. PubMed ID: 25347948
    [Abstract] [Full Text] [Related]

  • 19. Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population.
    Hindorf U, Peterson C, Almer S.
    Ther Drug Monit; 2004 Dec 28; 26(6):673-8. PubMed ID: 15570193
    [Abstract] [Full Text] [Related]

  • 20. [Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].
    Gisbert JP, González-Lama Y, Maté J.
    Gastroenterol Hepatol; 2006 Nov 28; 29(9):568-83. PubMed ID: 17129552
    [Abstract] [Full Text] [Related]

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