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Journal Abstract Search

674 related items for PubMed ID: 12048239

  • 1. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
    Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 11; 99(12):8025-30. PubMed ID: 12048239
    [Abstract] [Full Text] [Related]

  • 2. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 11; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

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  • 4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 11; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 5. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K.
    Am J Geriatr Psychiatry; 2013 May 11; 21(5):474-83. PubMed ID: 23570890
    [Abstract] [Full Text] [Related]

  • 6. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W.
    Exp Gerontol; 2000 Jul 11; 35(4):453-60. PubMed ID: 10959033
    [Abstract] [Full Text] [Related]

  • 7. Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
    Ikeuchi T, Sisodia SS.
    Neuromolecular Med; 2002 Jul 11; 1(1):43-54. PubMed ID: 12025815
    [Abstract] [Full Text] [Related]

  • 8. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 9. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
    Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C.
    EMBO J; 2002 Oct 15; 21(20):5408-16. PubMed ID: 12374741
    [Abstract] [Full Text] [Related]

  • 10. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
    Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE.
    J Neurochem; 2005 Oct 15; 95(2):446-56. PubMed ID: 16086682
    [Abstract] [Full Text] [Related]

  • 11. APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
    Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.
    Exp Cell Res; 2003 Jul 01; 287(1):1-9. PubMed ID: 12799176
    [Abstract] [Full Text] [Related]

  • 12. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
    Fukumori A, Fluhrer R, Steiner H, Haass C.
    J Neurosci; 2010 Jun 09; 30(23):7853-62. PubMed ID: 20534834
    [Abstract] [Full Text] [Related]

  • 13. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA, Schenk DB, Basi GS.
    Curr Alzheimer Res; 2013 Jan 09; 10(1):4-10. PubMed ID: 22950863
    [Abstract] [Full Text] [Related]

  • 14. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 15. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
    Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.
    J Biol Chem; 2002 Sep 27; 277(39):36521-6. PubMed ID: 12119298
    [Abstract] [Full Text] [Related]

  • 16. Mutations in APP have independent effects on Abeta and CTFgamma generation.
    Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM.
    Neurobiol Dis; 2004 Nov 27; 17(2):205-18. PubMed ID: 15474359
    [Abstract] [Full Text] [Related]

  • 17. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.
    Murphy MP, Uljon SN, Golde TE, Wang R.
    Biochim Biophys Acta; 2002 Mar 16; 1586(2):199-209. PubMed ID: 11959461
    [Abstract] [Full Text] [Related]

  • 18. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R.
    Nature; 1999 Apr 08; 398(6727):518-22. PubMed ID: 10206645
    [Abstract] [Full Text] [Related]

  • 19. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS.
    Biochemistry; 2003 Jun 24; 42(24):7580-6. PubMed ID: 12809514
    [Abstract] [Full Text] [Related]

  • 20. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
    Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P.
    Proc Natl Acad Sci U S A; 2002 Oct 29; 99(22):14452-7. PubMed ID: 12388777
    [Abstract] [Full Text] [Related]

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