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269 related items for PubMed ID: 12049632

  • 1. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism.
    Holness MJ, Smith ND, Bulmer K, Hopkins T, Gibbons GF, Sugden MC.
    Biochem J; 2002 Jun 15; 364(Pt 3):687-94. PubMed ID: 12049632
    [Abstract] [Full Text] [Related]

  • 2. Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.
    Holness MJ, Bulmer K, Smith ND, Sugden MC.
    Biochem J; 2003 Feb 01; 369(Pt 3):687-95. PubMed ID: 12435272
    [Abstract] [Full Text] [Related]

  • 3. Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).
    Holness MJ, Bulmer K, Gibbons GF, Sugden MC.
    Biochem J; 2002 Sep 15; 366(Pt 3):839-46. PubMed ID: 12099888
    [Abstract] [Full Text] [Related]

  • 4. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.
    Wu P, Peters JM, Harris RA.
    Biochem Biophys Res Commun; 2001 Sep 21; 287(2):391-6. PubMed ID: 11554740
    [Abstract] [Full Text] [Related]

  • 5. Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.
    Sugden MC, Bulmer K, Gibbons GF, Holness MJ.
    Arch Biochem Biophys; 2001 Nov 15; 395(2):246-52. PubMed ID: 11697863
    [Abstract] [Full Text] [Related]

  • 6. Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.
    Sugden MC, Bulmer K, Augustine D, Holness MJ.
    Diabetes; 2001 Dec 15; 50(12):2729-36. PubMed ID: 11723055
    [Abstract] [Full Text] [Related]

  • 7. Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.
    Sugden MC, Bulmer K, Gibbons GF, Knight BL, Holness MJ.
    Biochem J; 2002 Jun 01; 364(Pt 2):361-8. PubMed ID: 12023878
    [Abstract] [Full Text] [Related]

  • 8. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.
    Sugden MC, Holness MJ.
    Curr Drug Targets Immune Endocr Metabol Disord; 2002 Jul 01; 2(2):151-65. PubMed ID: 12476789
    [Abstract] [Full Text] [Related]

  • 9. Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.
    Osabe M, Sugatani J, Fukuyama T, Ikushiro S, Ikari A, Miwa M.
    Drug Metab Dispos; 2008 Feb 01; 36(2):294-302. PubMed ID: 17967931
    [Abstract] [Full Text] [Related]

  • 10. Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation.
    Nanji AA, Dannenberg AJ, Jokelainen K, Bass NM.
    J Pharmacol Exp Ther; 2004 Jul 01; 310(1):417-24. PubMed ID: 15016835
    [Abstract] [Full Text] [Related]

  • 11. Transcriptional regulation of cellular retinol-binding protein, type II gene expression in small intestine by dietary fat.
    Suruga K, Mochizuki K, Kitagawa M, Goda T, Horie N, Takeishi K, Takase S.
    Arch Biochem Biophys; 1999 Feb 01; 362(1):159-66. PubMed ID: 9917340
    [Abstract] [Full Text] [Related]

  • 12. Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.
    Savkur RS, Bramlett KS, Michael LF, Burris TP.
    Biochem Biophys Res Commun; 2005 Apr 01; 329(1):391-6. PubMed ID: 15721319
    [Abstract] [Full Text] [Related]

  • 13. Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.
    Kannisto K, Chibalin A, Glinghammar B, Zierath JR, Hamsten A, Ehrenborg E.
    Int J Mol Med; 2006 Jan 01; 17(1):45-52. PubMed ID: 16328010
    [Abstract] [Full Text] [Related]

  • 14. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.
    Sumanasekera WK, Tien ES, Davis JW, Turpey R, Perdew GH, Vanden Heuvel JP.
    Biochemistry; 2003 Sep 16; 42(36):10726-35. PubMed ID: 12962497
    [Abstract] [Full Text] [Related]

  • 15. Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate.
    Sugden MC, Orfali KA, Fryer LG, Holness MJ, Priestman DA.
    J Mol Cell Cardiol; 1997 Jul 16; 29(7):1867-75. PubMed ID: 9236140
    [Abstract] [Full Text] [Related]

  • 16. Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids.
    Stavinoha MA, Rayspellicy JW, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME.
    Am J Physiol Endocrinol Metab; 2004 Nov 16; 287(5):E878-87. PubMed ID: 15292029
    [Abstract] [Full Text] [Related]

  • 17. Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.
    Yoon M, Lee H, Jeong S, Kim JJ, Nicol CJ, Nam KW, Kim M, Cho BG, Oh GT.
    Br J Pharmacol; 2003 Apr 16; 138(7):1295-302. PubMed ID: 12711630
    [Abstract] [Full Text] [Related]

  • 18. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
    Lee GY, Kim NH, Zhao ZS, Cha BS, Kim YS.
    Biochem J; 2004 Mar 15; 378(Pt 3):983-90. PubMed ID: 14641110
    [Abstract] [Full Text] [Related]

  • 19. Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin.
    Huang B, Wu P, Bowker-Kinley MM, Harris RA.
    Diabetes; 2002 Feb 15; 51(2):276-83. PubMed ID: 11812733
    [Abstract] [Full Text] [Related]

  • 20. Peroxisome proliferator-activated receptor-alpha mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene, a ligand of constitutive androstane receptor.
    Columbano A, Ledda-Columbano GM, Pibiri M, Concas D, Reddy JK, Rao MS.
    Hepatology; 2001 Aug 15; 34(2):262-6. PubMed ID: 11481610
    [Abstract] [Full Text] [Related]

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