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Journal Abstract Search

638 related items for PubMed ID: 12050673

  • 1. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
    Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY.
    Nature; 2002 Jun 27; 417(6892):975-8. PubMed ID: 12050673
    [Abstract] [Full Text] [Related]

  • 2. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
    Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP.
    Science; 2002 Jun 07; 296(5574):1886-9. PubMed ID: 12004076
    [Abstract] [Full Text] [Related]

  • 3. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.
    Science; 2001 Apr 20; 292(5516):468-72. PubMed ID: 11292861
    [Abstract] [Full Text] [Related]

  • 4. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.
    IUBMB Life; 2001 Jul 20; 52(1-2):43-7. PubMed ID: 11795592
    [Abstract] [Full Text] [Related]

  • 5. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
    Miller F, Kentsis A, Osman R, Pan ZQ.
    J Biol Chem; 2005 Mar 04; 280(9):7985-96. PubMed ID: 15611064
    [Abstract] [Full Text] [Related]

  • 6. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor.
    Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A.
    J Chem Theory Comput; 2015 Aug 11; 11(8):3946-54. PubMed ID: 26574473
    [Abstract] [Full Text] [Related]

  • 7. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.
    J Biol Chem; 2003 Feb 28; 278(9):6816-23. PubMed ID: 12468553
    [Abstract] [Full Text] [Related]

  • 8. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
    Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ.
    EMBO J; 2001 Sep 17; 20(18):5197-206. PubMed ID: 11566883
    [Abstract] [Full Text] [Related]

  • 9. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer.
    Maynard MA, Ohh M.
    Am J Nephrol; 2004 Sep 17; 24(1):1-13. PubMed ID: 14654728
    [Abstract] [Full Text] [Related]

  • 10. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
    Pugh CW, Ratcliffe PJ.
    Semin Cancer Biol; 2003 Feb 17; 13(1):83-9. PubMed ID: 12507560
    [Abstract] [Full Text] [Related]

  • 11. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
    Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.
    J Biol Chem; 2000 Aug 18; 275(33):25733-41. PubMed ID: 10823831
    [Abstract] [Full Text] [Related]

  • 12. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.
    Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G.
    EMBO J; 2003 Apr 15; 22(8):1857-67. PubMed ID: 12682018
    [Abstract] [Full Text] [Related]

  • 13. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
    Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.
    Nature; 1999 May 20; 399(6733):271-5. PubMed ID: 10353251
    [Abstract] [Full Text] [Related]

  • 14. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
    Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER.
    Oncogene; 2001 Aug 16; 20(36):5067-74. PubMed ID: 11526493
    [Abstract] [Full Text] [Related]

  • 15. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K, Makino Y, Pereira T, Poellinger L.
    EMBO J; 2000 Aug 15; 19(16):4298-309. PubMed ID: 10944113
    [Abstract] [Full Text] [Related]

  • 16. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau.
    Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE.
    J Biol Chem; 2003 Feb 28; 278(9):7558-63. PubMed ID: 12482756
    [Abstract] [Full Text] [Related]

  • 17. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
    Illingworth CJ, Loenarz C, Schofield CJ, Domene C.
    Biochemistry; 2010 Aug 17; 49(32):6936-44. PubMed ID: 20695530
    [Abstract] [Full Text] [Related]

  • 18. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
    Yuan Y, Hilliard G, Ferguson T, Millhorn DE.
    J Biol Chem; 2003 May 02; 278(18):15911-6. PubMed ID: 12606543
    [Abstract] [Full Text] [Related]

  • 19. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
    Hansen WJ, Ohh M, Moslehi J, Kondo K, Kaelin WG, Welch WJ.
    Mol Cell Biol; 2002 Mar 02; 22(6):1947-60. PubMed ID: 11865071
    [Abstract] [Full Text] [Related]

  • 20. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
    Yu F, White SB, Zhao Q, Lee FS.
    Proc Natl Acad Sci U S A; 2001 Aug 14; 98(17):9630-5. PubMed ID: 11504942
    [Abstract] [Full Text] [Related]

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