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Journal Abstract Search

145 related items for PubMed ID: 12057649

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  • 2. Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template.
    Hirayama F, Koshio H, Katayama N, Ishihara T, Kaizawa H, Taniuchi Y, Sato K, Sakai-Moritani Y, Kaku S, Kurihara H, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S.
    Bioorg Med Chem; 2003 Feb 06; 11(3):367-81. PubMed ID: 12517432
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  • 5. Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
    Sato K, Taniuchi Y, Kawasaki T, Hirayama F, Koshio H, Matsumoto Y, Iizumi Y.
    Jpn J Pharmacol; 1998 Oct 06; 78(2):191-7. PubMed ID: 9829622
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  • 6. Dibasic (amidinoaryl)propanoic acid derivatives as novel blood coagulation factor Xa inhibitors.
    Nagahara T, Yokoyama Y, Inamura K, Katakura S, Komoriya S, Yamaguchi H, Hara T, Iwamoto M.
    J Med Chem; 1994 Apr 15; 37(8):1200-7. PubMed ID: 8164262
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  • 8. Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
    Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR.
    Bioorg Med Chem Lett; 2003 Feb 10; 13(3):369-73. PubMed ID: 12565931
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  • 10. Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors.
    Koshio H, Hirayama F, Ishihara T, Shiraki R, Shigenaga T, Taniuchi Y, Sato K, Moritani Y, Iwatsuki Y, Kaku S, Katayama N, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1305-23. PubMed ID: 15670939
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  • 13. Design, synthesis and biological activity of amidinobicyclic compounds (derivatives of DX-9065a) as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
    Komoriya S, Kanaya N, Nagahara T, Yokoyama A, Inamura K, Yokoyama Y, Katakura S, Hara T.
    Bioorg Med Chem; 2004 May 01; 12(9):2099-114. PubMed ID: 15080912
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  • 14. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles.
    Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T.
    J Thromb Haemost; 2008 Sep 01; 6(9):1542-9. PubMed ID: 18624979
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  • 15. Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.
    Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, Wong PC, Wexler RR, Lam PY.
    J Med Chem; 2001 Feb 15; 44(4):566-78. PubMed ID: 11170646
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  • 17. Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.
    Hirayama F, Koshio H, Ishihara T, Hachiya S, Sugasawa K, Koga Y, Seki N, Shiraki R, Shigenaga T, Iwatsuki Y, Moritani Y, Mori K, Kadokura T, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S.
    J Med Chem; 2011 Dec 08; 54(23):8051-65. PubMed ID: 21995444
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  • 18. Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.
    Wiley MR, Weir LC, Briggs S, Bryan NA, Buben J, Campbell C, Chirgadze NY, Conrad RC, Craft TJ, Ficorilli JV, Franciskovich JB, Froelich LL, Gifford-Moore DS, Goodson T, Herron DK, Klimkowski VJ, Kurz KD, Kyle JA, Masters JJ, Ratz AM, Milot G, Shuman RT, Smith T, Smith GF, Tebbe AL, Tinsley JM.
    J Med Chem; 2000 Mar 09; 43(5):883-99. PubMed ID: 10715155
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  • 19. Design, synthesis, and biological activity of piperidine diamine derivatives as factor Xa inhibitor.
    Mochizuki A, Nakamoto Y, Naito H, Uoto K, Ohta T.
    Bioorg Med Chem Lett; 2008 Jan 15; 18(2):782-7. PubMed ID: 18039572
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