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Journal Abstract Search

180 related items for PubMed ID: 12061251

  • 1. Synthesis and biological activity of disubstituted 4,5-polymethylenepyrazoles as selective cyclooxygenase-2 inhibitors.
    Yu JW, Kim HH, Jahng Y.
    Pharmazie; 2002 May; 57(5):301-5. PubMed ID: 12061251
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and biological acitivity of annulated pyrazoles as selective COX-2 inhibitors. I.
    Kim HH, Park JG, Moon TC, Chang HW, Jahng Y.
    Arch Pharm Res; 1999 Aug; 22(4):372-9. PubMed ID: 10489876
    [Abstract] [Full Text] [Related]

  • 3. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
    Ranatunge RR, Earl RA, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schwalb DJ, Young DV, Zemtseva IS.
    Bioorg Med Chem Lett; 2004 Dec 20; 14(24):6049-52. PubMed ID: 15546727
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles.
    Ranatunge RR, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Young DV, Zemetseva IS.
    Bioorg Med Chem; 2004 Mar 15; 12(6):1357-66. PubMed ID: 15018908
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2005 Aug 01; 13(15):4694-703. PubMed ID: 15914011
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.
    Ranatunge RR, Augustyniak M, Bandarage UK, Earl RA, Ellis JL, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schroeder JD, Shumway MJ, Tam SW, Trocha AM, Young DV.
    J Med Chem; 2004 Apr 22; 47(9):2180-93. PubMed ID: 15084117
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
    Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC.
    J Med Chem; 1997 Apr 25; 40(9):1347-65. PubMed ID: 9135032
    [Abstract] [Full Text] [Related]

  • 8. 1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.
    Sui Z, Guan J, Ferro MP, McCoy K, Wachter MP, Murray WV, Singer M, Steber M, Ritchie DM, Argentieri DC.
    Bioorg Med Chem Lett; 2000 Mar 20; 10(6):601-4. PubMed ID: 10741562
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors.
    Patel MV, Bell R, Majest S, Henry R, Kolasa T.
    J Org Chem; 2004 Oct 15; 69(21):7058-65. PubMed ID: 15471453
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
    Pal M, Madan M, Padakanti S, Pattabiraman VR, Kalleda S, Vanguri A, Mullangi R, Mamidi NV, Casturi SR, Malde A, Gopalakrishnan B, Yeleswarapu KR.
    J Med Chem; 2003 Sep 11; 46(19):3975-84. PubMed ID: 12954051
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of (E)- and (Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors.
    Reddy MV, Mallireddigari MR, Pallela VR, Venkatapuram P, Boominathan R, Bell SC, Reddy EP.
    Bioorg Med Chem; 2005 Mar 01; 13(5):1715-23. PubMed ID: 15698789
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr 01; 60(4):327-32. PubMed ID: 15848208
    [Abstract] [Full Text] [Related]

  • 13. Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
    Beswick P, Bingham S, Bountra C, Brown T, Browning K, Campbell I, Chessell I, Clayton N, Collins S, Corfield J, Guntrip S, Haslam C, Lambeth P, Lucas F, Mathews N, Murkit G, Naylor A, Pegg N, Pickup E, Player H, Price H, Stevens A, Stratton S, Wiseman J.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5445-8. PubMed ID: 15454242
    [Abstract] [Full Text] [Related]

  • 14. Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.
    Uddin MJ, Rao PN, McDonald R, Knaus EE.
    Bioorg Med Chem Lett; 2005 Jan 17; 15(2):439-42. PubMed ID: 15603969
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors.
    Khanapure SP, Garvey DS, Young DV, Ezawa M, Earl RA, Gaston RD, Fang X, Murty M, Martino A, Shumway M, Trocha M, Marek P, Tam SW, Janero DR, Letts LG.
    J Med Chem; 2003 Dec 04; 46(25):5484-504. PubMed ID: 14640557
    [Abstract] [Full Text] [Related]

  • 16. 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
    Singh SK, Vobbalareddy S, Kalleda SR, Rajjak SA, Casturi SR, Datla SR, Mamidi RN, Mullangi R, Bhamidipati R, Ramanujam R, Akella V, Yeleswarapu KR.
    Org Biomol Chem; 2004 Sep 07; 2(17):2442-50. PubMed ID: 15326524
    [Abstract] [Full Text] [Related]

  • 17. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.
    Ergün BC, Nuñez MT, Labeaga L, Ledo F, Darlington J, Bain G, Cakir B, Banoglu E.
    Arzneimittelforschung; 2010 Sep 07; 60(8):497-505. PubMed ID: 20863006
    [Abstract] [Full Text] [Related]

  • 18. Cyclooxygenase (COX) inhibitors: a comparative QSAR study.
    Garg R, Kurup A, Mekapati SB, Hansch C.
    Chem Rev; 2003 Mar 07; 103(3):703-32. PubMed ID: 12630850
    [No Abstract] [Full Text] [Related]

  • 19. Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide.
    Sano H, Noguchi T, Tanatani A, Hashimoto Y, Miyachi H.
    Bioorg Med Chem; 2005 May 02; 13(9):3079-91. PubMed ID: 15809144
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors.
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2005 Apr 01; 13(7):2459-68. PubMed ID: 15755648
    [Abstract] [Full Text] [Related]

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