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Journal Abstract Search

170 related items for PubMed ID: 12086495

  • 1. Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
    Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD.
    J Med Chem; 2002 Jul 04; 45(14):3094-102. PubMed ID: 12086495
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  • 2. Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.
    Böhme TM, Keim C, Kreutzmann K, Linder M, Dingermann T, Dannhardt G, Mutschler E, Lambrecht G.
    J Med Chem; 2003 Feb 27; 46(5):856-67. PubMed ID: 12593665
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  • 4. Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
    Tecle H, Barrett SD, Lauffer DJ, Augelli-Szafran C, Brann MR, Callahan MJ, Caprathe BW, Davis RE, Doyle PD, Eubanks D, Lipiniski W, Mirzadegan T, Moos WH, Moreland DW, Nelson CB, Pavia MR, Raby C, Schwarz RD, Spencer CJ, Thomas AJ, Jaen JC.
    J Med Chem; 1998 Jul 02; 41(14):2524-36. PubMed ID: 9651157
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  • 5. Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
    Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C.
    Bioorg Med Chem; 2007 Dec 15; 15(24):7626-37. PubMed ID: 17889543
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  • 6. Activation of cerebral function by CS-932, a functionally selective M1 partial agonist: neurochemical characterization and pharmacological studies.
    Iwata N, Kozuka M, Hara T, Kanek T, Tonohiro T, Sugimoto M, Niitsu Y, Kondo Y, Yamamoto T, Sakai J, Nagano M.
    Jpn J Pharmacol; 2000 Nov 15; 84(3):266-80. PubMed ID: 11138727
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  • 7. Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.
    Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE.
    Bioorg Med Chem Lett; 2002 Apr 08; 12(7):1087-91. PubMed ID: 11909724
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  • 10. 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
    Pei XF, Gupta TH, Badio B, Padgett WL, Daly JW.
    J Med Chem; 1998 Jun 04; 41(12):2047-55. PubMed ID: 9622546
    [Abstract] [Full Text] [Related]

  • 11. CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology.
    Tecle H, Schwarz RD, Barrett SD, Callahan MJ, Caprathe BW, Davis RE, Doyle P, Emmerling M, Lauffer DJ, Mirzadegan T, Moreland DW, Lipiniski W, Nelson C, Raby C, Spencer C, Spiegel K, Thomas AJ, Jaen JC.
    Pharm Acta Helv; 2000 Mar 04; 74(2-3):141-8. PubMed ID: 10812951
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  • 13. Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.
    Sagara Y, Sagara T, Mase T, Kimura T, Numazawa T, Fujikawa T, Noguchi K, Ohtake N.
    J Med Chem; 2002 Feb 14; 45(4):984-7. PubMed ID: 11831911
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  • 15. PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP.
    Olianas MC, Onali P.
    Life Sci; 1999 Feb 14; 65(21):2233-40. PubMed ID: 10576595
    [Abstract] [Full Text] [Related]

  • 16. A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.
    Mitsuya M, Kobayashi K, Kawakami K, Satoh A, Ogino Y, Kakikawa T, Ohtake N, Kimura T, Hirose H, Sato A, Numazawa T, Hasegawa T, Noguchi K, Mase T.
    J Med Chem; 2000 Dec 28; 43(26):5017-29. PubMed ID: 11150173
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  • 18. Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.
    Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE.
    Bioorg Med Chem Lett; 2000 Oct 16; 10(20):2247-50. PubMed ID: 11055330
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  • 19. Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
    Bolognesi ML, Minarini A, Budriesi R, Cacciaguerra S, Chiarini A, Spampinato S, Tumiatti V, Melchiorre C.
    J Med Chem; 1998 Oct 08; 41(21):4150-60. PubMed ID: 9767650
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