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474 related items for PubMed ID: 12101228

  • 1. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein.
    Groulx I, Lee S.
    Mol Cell Biol; 2002 Aug; 22(15):5319-36. PubMed ID: 12101228
    [Abstract] [Full Text] [Related]

  • 2. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.
    Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD.
    Mol Cell Biol; 1999 Feb; 19(2):1486-97. PubMed ID: 9891082
    [Abstract] [Full Text] [Related]

  • 3. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K, Makino Y, Pereira T, Poellinger L.
    EMBO J; 2000 Aug 15; 19(16):4298-309. PubMed ID: 10944113
    [Abstract] [Full Text] [Related]

  • 4. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.
    Biochem J; 2004 Aug 01; 381(Pt 3):761-7. PubMed ID: 15104534
    [Abstract] [Full Text] [Related]

  • 5. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.
    Bonicalzi ME, Groulx I, de Paulsen N, Lee S.
    J Biol Chem; 2001 Jan 12; 276(2):1407-16. PubMed ID: 11024059
    [Abstract] [Full Text] [Related]

  • 6. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.
    J Biol Chem; 2003 Oct 03; 278(40):38183-7. PubMed ID: 12876291
    [Abstract] [Full Text] [Related]

  • 7. Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2.
    Groulx I, Bonicalzi ME, Lee S.
    J Biol Chem; 2000 Mar 24; 275(12):8991-9000. PubMed ID: 10722748
    [Abstract] [Full Text] [Related]

  • 8. Activation of hypoxia-induced transcription in normoxia.
    Hägg M, Wennström S.
    Exp Cell Res; 2005 May 15; 306(1):180-91. PubMed ID: 15878343
    [Abstract] [Full Text] [Related]

  • 9. The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
    Tang TT, Lasky LA.
    J Biol Chem; 2003 Aug 08; 278(32):30125-35. PubMed ID: 12761217
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
    Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS.
    Mol Cell Biol; 2003 Jul 08; 23(14):4959-71. PubMed ID: 12832481
    [Abstract] [Full Text] [Related]

  • 11. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.
    Oncogene; 2000 Nov 16; 19(48):5435-43. PubMed ID: 11114720
    [Abstract] [Full Text] [Related]

  • 12. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.
    J Biol Chem; 2003 Feb 28; 278(9):6816-23. PubMed ID: 12468553
    [Abstract] [Full Text] [Related]

  • 13. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
    Yu F, White SB, Zhao Q, Lee FS.
    Cancer Res; 2001 May 15; 61(10):4136-42. PubMed ID: 11358837
    [Abstract] [Full Text] [Related]

  • 14. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
    Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.
    Nature; 1999 May 20; 399(6733):271-5. PubMed ID: 10353251
    [Abstract] [Full Text] [Related]

  • 15. HIF activation by pH-dependent nucleolar sequestration of VHL.
    Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S.
    Nat Cell Biol; 2004 Jul 20; 6(7):642-7. PubMed ID: 15181450
    [Abstract] [Full Text] [Related]

  • 16. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
    Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.
    Mol Cell; 2005 Feb 18; 17(4):503-12. PubMed ID: 15721254
    [Abstract] [Full Text] [Related]

  • 17. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.
    IUBMB Life; 2001 Jul 18; 52(1-2):43-7. PubMed ID: 11795592
    [Abstract] [Full Text] [Related]

  • 18. Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.
    Khacho M, Mekhail K, Pilon-Larose K, Payette J, Lee S.
    Mol Cell Biol; 2008 Jan 18; 28(1):302-14. PubMed ID: 17967880
    [Abstract] [Full Text] [Related]

  • 19. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
    Pugh CW, Ratcliffe PJ.
    Semin Cancer Biol; 2003 Feb 18; 13(1):83-9. PubMed ID: 12507560
    [Abstract] [Full Text] [Related]

  • 20. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.
    Science; 2001 Apr 20; 292(5516):468-72. PubMed ID: 11292861
    [Abstract] [Full Text] [Related]

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