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126 related items for PubMed ID: 12113837

  • 1. Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue.
    Smith AB, Corbett RM, Pettit GR, Chapuis JC, Schmidt JM, Hamel E, Jung MK.
    Bioorg Med Chem Lett; 2002 Aug 05; 12(15):2039-42. PubMed ID: 12113837
    [Abstract] [Full Text] [Related]

  • 2. Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
    Uckun FM, Mao C, Vassilev AO, Huang H, Jan ST.
    Bioorg Med Chem Lett; 2000 Mar 20; 10(6):541-5. PubMed ID: 10741549
    [Abstract] [Full Text] [Related]

  • 3. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.
    Biochemistry; 1995 Aug 01; 34(30):9714-21. PubMed ID: 7626642
    [Abstract] [Full Text] [Related]

  • 4. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
    Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.
    Mol Pharmacol; 1993 Oct 01; 44(4):757-66. PubMed ID: 8232226
    [Abstract] [Full Text] [Related]

  • 5. Spongistatins as tubulin targeting agents.
    Uckun FM, Mao C, Jan ST, Huang H, Vassilev AO, Navara CS, Narla RK.
    Curr Pharm Des; 2001 Sep 01; 7(13):1291-6. PubMed ID: 11472268
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of the C(2)-C(13) fragment (the A-B spiroketal unit) of spongistatin 1 (altohyrtin A): use of a common intermediate for the synthesis of both spongistatin spiroketals.
    Holson EB, Roush WR.
    Org Lett; 2002 Oct 17; 4(21):3723-5. PubMed ID: 12375928
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.
    Paterson I, Aceña JL, Bach J, Chen DY, Coster MJ.
    Chem Commun (Camb); 2003 Feb 21; (4):462-3. PubMed ID: 12638950
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
    Smith AB, Lin Q, Pettit GR, Chapuis JC, Schmidt JM.
    Bioorg Med Chem Lett; 1998 Mar 17; 8(6):567-8. PubMed ID: 9871561
    [Abstract] [Full Text] [Related]

  • 9. Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled iodo-spiroketalization reaction.
    Holson EB, Roush WR.
    Org Lett; 2002 Oct 17; 4(21):3719-22. PubMed ID: 12375927
    [Abstract] [Full Text] [Related]

  • 10. Synthesis of the C16-C28 spiroketal subunit of spongistatin 1 (altohyrtin A): the pyrone approach.
    Crimmins MT, Katz JD.
    Org Lett; 2000 Apr 06; 2(7):957-60. PubMed ID: 10768196
    [Abstract] [Full Text] [Related]

  • 11. An aldol approach to the synthesis of the EF fragment of spongistatin 1.
    Crimmins MT, Katz JD, McAtee LC, Tabet EA, Kirincich SJ.
    Org Lett; 2001 Mar 22; 3(6):949-52. PubMed ID: 11263923
    [Abstract] [Full Text] [Related]

  • 12. Structure-based design of novel anticancer agents.
    Uckun FM, Sudbeck EA, Mao C, Ghosh S, Liu XP, Vassilev AO, Navara CS, Narla RK.
    Curr Cancer Drug Targets; 2001 May 22; 1(1):59-71. PubMed ID: 12188892
    [Abstract] [Full Text] [Related]

  • 13. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
    ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW.
    Biochemistry; 1996 Jan 09; 35(1):243-50. PubMed ID: 8555181
    [Abstract] [Full Text] [Related]

  • 14. SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
    Uckun FM, Mao C, Jan ST, Huang H, Vassilev AO, Sudbeck EA, Navara CS, Narla RK.
    Curr Opin Investig Drugs; 2000 Oct 09; 1(2):252-6. PubMed ID: 11249582
    [Abstract] [Full Text] [Related]

  • 15. Unusual antimicrotubule activity of the antifungal agent spongistatin 1.
    Ovechkina YY, Pettit RK, Cichacz ZA, Pettit GR, Oakley BR.
    Antimicrob Agents Chemother; 1999 Aug 09; 43(8):1993-9. PubMed ID: 10428925
    [Abstract] [Full Text] [Related]

  • 16. Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38.
    Wang Y, Habgood GJ, Christ WJ, Kishi Y, Littlefield BA, Yu MJ.
    Bioorg Med Chem Lett; 2000 May 15; 10(10):1029-32. PubMed ID: 10843209
    [Abstract] [Full Text] [Related]

  • 17. Structurally simplified macrolactone analogues of halichondrin B.
    Seletsky BM, Wang Y, Hawkins LD, Palme MH, Habgood GJ, DiPietro LV, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5547-50. PubMed ID: 15482921
    [Abstract] [Full Text] [Related]

  • 18. Tubulin-perturbing naphthoquinone spiroketals.
    Balachandran R, Hopkins TD, Thomas CA, Wipf P, Day BW.
    Chem Biol Drug Des; 2008 Feb 15; 71(2):117-24. PubMed ID: 18194192
    [Abstract] [Full Text] [Related]

  • 19. An efficient strategy for the synthesis of endocyclic enol ethers and its application to the synthesis of spiroacetals.
    Fuwa H, Sasaki M.
    Org Lett; 2008 Jun 19; 10(12):2549-52. PubMed ID: 18484727
    [Abstract] [Full Text] [Related]

  • 20. Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin.
    Isbrucker RA, Cummins J, Pomponi SA, Longley RE, Wright AE.
    Biochem Pharmacol; 2003 Jul 01; 66(1):75-82. PubMed ID: 12818367
    [Abstract] [Full Text] [Related]

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