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120 related items for PubMed ID: 12116869

  • 1. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
    Orús L, Sáinz Y, Pérez S, Oficialdegui AM, Martinez J, Lasheras B, del Río J, Monge A.
    Pharmazie; 2002 Jun; 57(6):355-7. PubMed ID: 12116869
    [Abstract] [Full Text] [Related]

  • 2. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
    Orús L, Martínez J, Pérez S, Oficialdegui AM, del Castillo JC, Mourelle M, Lasheras B, del Río J, Monge A.
    Pharmazie; 2002 Aug; 57(8):515-8. PubMed ID: 12227188
    [Abstract] [Full Text] [Related]

  • 3. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
    Martínez J, Pérez S, Oficialdegui AM, Heras B, Orús L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo JC, Lasheras B, Tordera R, del Río J, Monge A.
    Eur J Med Chem; 2001 Jan; 36(1):55-61. PubMed ID: 11231049
    [Abstract] [Full Text] [Related]

  • 4. New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
    Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A.
    J Med Chem; 2001 Feb 01; 44(3):418-28. PubMed ID: 11462981
    [Abstract] [Full Text] [Related]

  • 5. New 3-[4-(2,3-dihydro-14-benzodioxin-5-yl)piperazin-1-yl]-1-(5-substituted benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT(1A) serotonin receptors and serotonin transporter as a new class of antidepressants.
    Silanes SP, Orús L, Oficialdegui AM, Martínez Esparza J, Lasheras B, Del Río J, Monge A.
    Pharmazie; 2004 Jul 01; 59(7):499-501. PubMed ID: 15296084
    [Abstract] [Full Text] [Related]

  • 6. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
    Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH.
    J Med Chem; 2004 Jul 15; 47(15):3823-42. PubMed ID: 15239661
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and in vitro pharmacological evaluation of a new series of 5-HT1A 5-HT2A and 5-HT2C receptor ligands containing a norbornene nucleus.
    Fiorino F, Severino B, De Angelis F, Perissutti E, Magli E, Frecentese F, Esposito A, Massarelli P, Nencini C, Viti B, Santagada V, Caliendo G.
    Pharmazie; 2009 Sep 15; 64(9):555-64. PubMed ID: 19827295
    [Abstract] [Full Text] [Related]

  • 8. Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.
    Meagher KL, Mewshaw RE, Evrard DA, Zhou P, Smith DL, Scerni R, Spangler T, Abulhawa S, Shi X, Schechter LE, Andree TH.
    Bioorg Med Chem Lett; 2001 Jul 23; 11(14):1885-8. PubMed ID: 11459653
    [Abstract] [Full Text] [Related]

  • 9. Substitution mode of the amide fragment in some new N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl]pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity.
    Paluchowska MH, Bugno R, Charakchieva-Minol S, Bojarski AJ, Wesołowska A.
    Pol J Pharmacol; 2001 Jul 23; 53(4):369-76. PubMed ID: 11990083
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
    Wróbel MZ, Chodkowski A, Herold F, Gomółka A, Kleps J, Mazurek AP, Pluciński F, Mazurek A, Nowak G, Siwek A, Stachowicz K, Sławińska A, Wolak M, Szewczyk B, Satała G, Bojarski AJ, Turło J.
    Eur J Med Chem; 2013 May 23; 63():484-500. PubMed ID: 23524160
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.
    Oficialdegui AM, Martinez J, Pérez S, Heras B, Irurzun M, Palop JA, Tordera R, Lasheras B, del Río J, Monge A.
    Farmaco; 2000 May 23; 55(5):345-53. PubMed ID: 10983279
    [Abstract] [Full Text] [Related]

  • 12. Expression cloning of a serotonin transporter: a new way to study antidepressant drugs.
    Hoffman BJ.
    Pharmacopsychiatry; 1994 Jan 23; 27(1):16-22. PubMed ID: 8159777
    [Abstract] [Full Text] [Related]

  • 13. Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
    Zhou D, Harrison BL, Shah U, Andree TH, Hornby GA, Scerni R, Schechter LE, Smith DL, Sullivan KM, Mewshaw RE.
    Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1338-41. PubMed ID: 16332439
    [Abstract] [Full Text] [Related]

  • 14. Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.
    Chalon S, Tarkiainen J, Garreau L, Hall H, Emond P, Vercouillie J, Farde L, Dasse P, Varnas K, Besnard JC, Halldin C, Guilloteau D.
    J Pharmacol Exp Ther; 2003 Jan 01; 304(1):81-7. PubMed ID: 12490578
    [Abstract] [Full Text] [Related]

  • 15. 1,2,3,4-tetrahydroisoquinoline derivatives; lipophilicity evaluation vs. 5-HT1A receptor affinity.
    Bojarski AJ, Mokrosz MJ.
    Pharmazie; 1999 Nov 01; 54(11):828-30. PubMed ID: 10603608
    [Abstract] [Full Text] [Related]

  • 16. Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
    Zhou D, Zhou P, Evrard DA, Meagher K, Webb M, Harrison BL, Huryn DM, Golembieski J, Hornby GA, Schechter LE, Smith DL, Andree TH, Mewshaw RE.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6707-23. PubMed ID: 18571421
    [Abstract] [Full Text] [Related]

  • 17. 3-[(Aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter.
    Nencetti S, Demontis GC, Mazzoni MR, Betti L, Banti I, Rossello A, Lapucci A.
    J Pharm Pharmacol; 2007 Oct 15; 59(10):1439-45. PubMed ID: 17910821
    [Abstract] [Full Text] [Related]

  • 18. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.
    Perrone R, Berardi F, Colabufo NA, Lacivita E, Larizza C, Leopoldo M, Tortorella V.
    J Pharm Pharmacol; 2005 Oct 15; 57(10):1319-27. PubMed ID: 16259761
    [Abstract] [Full Text] [Related]

  • 19. Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance.
    Richelson E.
    J Clin Psychiatry; 2003 Oct 15; 64 Suppl 13():5-12. PubMed ID: 14552650
    [Abstract] [Full Text] [Related]

  • 20. Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
    Zajdel P, Subra G, Bojarski AJ, Duszyńska B, Tatarczyńska E, Nikiforuk A, Chojnacka-Wójcik E, Pawłowski M, Martinez J.
    Bioorg Med Chem; 2007 Apr 15; 15(8):2907-19. PubMed ID: 17321139
    [Abstract] [Full Text] [Related]

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