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154 related items for PubMed ID: 12121968

  • 1. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.
    Cedazo-Minguez A, Popescu BO, Ankarcrona M, Nishimura T, Cowburn RF.
    J Biol Chem; 2002 Sep 27; 277(39):36646-55. PubMed ID: 12121968
    [Abstract] [Full Text] [Related]

  • 2. Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.
    Popescu BO, Cedazo-Minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, Cowburn RF.
    J Biol Chem; 2004 Feb 20; 279(8):6455-64. PubMed ID: 14625299
    [Abstract] [Full Text] [Related]

  • 3. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
    Tanii H, Ankarcrona M, Flood F, Nilsberth C, Mehta ND, Perez-Tur J, Winblad B, Benedikz E, Cowburn RF.
    Neuroscience; 2000 Feb 20; 95(2):593-601. PubMed ID: 10658639
    [Abstract] [Full Text] [Related]

  • 4. Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.
    Smith IF, Boyle JP, Vaughan PF, Pearson HA, Cowburn RF, Peers CS.
    Brain Res; 2002 Sep 13; 949(1-2):105-11. PubMed ID: 12213305
    [Abstract] [Full Text] [Related]

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  • 6. Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress.
    Vestling M, Wiehager B, Tanii H, Cowburn RF.
    J Neurosci Res; 2001 Nov 01; 66(3):448-56. PubMed ID: 11746362
    [Abstract] [Full Text] [Related]

  • 7. Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway.
    Puri S, Magenheimer BS, Maser RL, Ryan EM, Zien CA, Walker DD, Wallace DP, Hempson SJ, Calvet JP.
    J Biol Chem; 2004 Dec 31; 279(53):55455-64. PubMed ID: 15466861
    [Abstract] [Full Text] [Related]

  • 8. Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line.
    Flood F, Sundström E, Samuelsson EB, Wiehager B, Seiger A, Johnston JA, Cowburn RF.
    Neurochem Int; 2004 Jun 31; 44(7):487-96. PubMed ID: 15209417
    [Abstract] [Full Text] [Related]

  • 9. Intracellular calcium involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells.
    Sawisky GR, Chang JP.
    J Neuroendocrinol; 2005 Jun 31; 17(6):353-71. PubMed ID: 15929741
    [Abstract] [Full Text] [Related]

  • 10. Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.
    Nguyen HN, Wang C, Perry DC.
    Brain Res; 2002 Jan 11; 924(2):159-66. PubMed ID: 11750901
    [Abstract] [Full Text] [Related]

  • 11. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
    Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP.
    J Neurosci; 1997 Jun 01; 17(11):4212-22. PubMed ID: 9151738
    [Abstract] [Full Text] [Related]

  • 12. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
    Popescu BO, Cedazo-Minguez A, Popescu LM, Winblad B, Cowburn RF, Ankarcrona M.
    J Neurosci Res; 2001 Oct 01; 66(1):122-34. PubMed ID: 11599009
    [Abstract] [Full Text] [Related]

  • 13. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
    Sudoh S, Kawamura Y, Sato S, Wang R, Saido TC, Oyama F, Sakaki Y, Komano H, Yanagisawa K.
    J Neurochem; 1998 Oct 01; 71(4):1535-43. PubMed ID: 9751187
    [Abstract] [Full Text] [Related]

  • 14. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.
    Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S.
    J Neurosci Res; 2003 Oct 15; 74(2):184-91. PubMed ID: 14515347
    [Abstract] [Full Text] [Related]

  • 15. Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells.
    Liu QH, Zheng YM, Wang YX.
    Pflugers Arch; 2007 Jan 15; 453(4):531-41. PubMed ID: 17093969
    [Abstract] [Full Text] [Related]

  • 16. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH.
    Mol Neurobiol; 2015 Dec 15; 52(3):1835-1849. PubMed ID: 25394380
    [Abstract] [Full Text] [Related]

  • 17. Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y.
    Plant LD, Boyle JP, Thomas NM, Hipkins NJ, Benedikz E, Hooper NM, Henderson Z, Vaughan PF, Peers C, Cowburn RF, Pearson HA.
    Neuroreport; 2002 Aug 27; 13(12):1553-6. PubMed ID: 12218704
    [Abstract] [Full Text] [Related]

  • 18. Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.
    Zholos AV, Tsytsyura YD, Gordienko DV, Tsvilovskyy VV, Bolton TB.
    Br J Pharmacol; 2004 Jan 27; 141(1):23-36. PubMed ID: 14662735
    [Abstract] [Full Text] [Related]

  • 19. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC, Ghadge GD, Miller RJ, Roos RP.
    J Neurochem; 1999 Jul 27; 73(1):31-40. PubMed ID: 10386952
    [Abstract] [Full Text] [Related]

  • 20. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
    Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M.
    J Biol Chem; 2005 May 13; 280(19):19070-7. PubMed ID: 15764596
    [Abstract] [Full Text] [Related]

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