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Journal Abstract Search

125 related items for PubMed ID: 12123724

  • 1. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
    Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH.
    Adv Enzyme Regul; 2002; 42():333-47. PubMed ID: 12123724
    [No Abstract] [Full Text] [Related]

  • 2. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
    Miller F, Kentsis A, Osman R, Pan ZQ.
    J Biol Chem; 2005 Mar 04; 280(9):7985-96. PubMed ID: 15611064
    [Abstract] [Full Text] [Related]

  • 3. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
    Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.
    J Biol Chem; 2000 Aug 18; 275(33):25733-41. PubMed ID: 10823831
    [Abstract] [Full Text] [Related]

  • 4. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.
    IUBMB Life; 2001 Jul 18; 52(1-2):43-7. PubMed ID: 11795592
    [Abstract] [Full Text] [Related]

  • 5. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
    Yuan Y, Hilliard G, Ferguson T, Millhorn DE.
    J Biol Chem; 2003 May 02; 278(18):15911-6. PubMed ID: 12606543
    [Abstract] [Full Text] [Related]

  • 6. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.
    J Biol Chem; 2003 Feb 28; 278(9):6816-23. PubMed ID: 12468553
    [Abstract] [Full Text] [Related]

  • 7. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
    Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG.
    Science; 2001 Apr 20; 292(5516):464-8. PubMed ID: 11292862
    [Abstract] [Full Text] [Related]

  • 8. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.
    Science; 2001 Apr 20; 292(5516):468-72. PubMed ID: 11292861
    [Abstract] [Full Text] [Related]

  • 9. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.
    Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.
    J Biol Chem; 2004 Sep 24; 279(39):40337-44. PubMed ID: 15271983
    [Abstract] [Full Text] [Related]

  • 10. The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
    Tang TT, Lasky LA.
    J Biol Chem; 2003 Aug 08; 278(32):30125-35. PubMed ID: 12761217
    [Abstract] [Full Text] [Related]

  • 11. Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
    Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M.
    J Biol Chem; 2003 Mar 28; 278(13):11032-40. PubMed ID: 12538644
    [Abstract] [Full Text] [Related]

  • 12. HIF hydroxylation and the mammalian oxygen-sensing pathway.
    Safran M, Kaelin WG.
    J Clin Invest; 2003 Mar 28; 111(6):779-83. PubMed ID: 12639980
    [No Abstract] [Full Text] [Related]

  • 13. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein.
    Groulx I, Lee S.
    Mol Cell Biol; 2002 Aug 28; 22(15):5319-36. PubMed ID: 12101228
    [Abstract] [Full Text] [Related]

  • 14. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.
    J Biol Chem; 2003 Oct 03; 278(40):38183-7. PubMed ID: 12876291
    [Abstract] [Full Text] [Related]

  • 15. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
    Pugh CW, Ratcliffe PJ.
    Semin Cancer Biol; 2003 Feb 03; 13(1):83-9. PubMed ID: 12507560
    [Abstract] [Full Text] [Related]

  • 16. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer.
    Kim W, Kaelin WG.
    Curr Opin Genet Dev; 2003 Feb 03; 13(1):55-60. PubMed ID: 12573436
    [Abstract] [Full Text] [Related]

  • 17. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
    Masson N, Ratcliffe PJ.
    J Cell Sci; 2003 Aug 01; 116(Pt 15):3041-9. PubMed ID: 12829734
    [Abstract] [Full Text] [Related]

  • 18. Oxygen sensors and angiogenesis.
    Maxwell PH, Ratcliffe PJ.
    Semin Cell Dev Biol; 2002 Feb 01; 13(1):29-37. PubMed ID: 11969369
    [Abstract] [Full Text] [Related]

  • 19. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.
    Oncogene; 2000 Nov 16; 19(48):5435-43. PubMed ID: 11114720
    [Abstract] [Full Text] [Related]

  • 20. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
    Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY.
    Nature; 2002 Jun 27; 417(6892):975-8. PubMed ID: 12050673
    [Abstract] [Full Text] [Related]

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