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183 related items for PubMed ID: 12130738

  • 1. SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties.
    Moser PC, Bergis OE, Jegham S, Lochead A, Duconseille E, Terranova JP, Caille D, Berque-Bestel I, Lezoualc'h F, Fischmeister R, Dumuis A, Bockaert J, George P, Soubrié P, Scatton B.
    J Pharmacol Exp Ther; 2002 Aug; 302(2):731-41. PubMed ID: 12130738
    [Abstract] [Full Text] [Related]

  • 2. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia.
    Micale V, Leggio GM, Mazzola C, Drago F.
    Brain Res; 2006 Nov 22; 1121(1):207-15. PubMed ID: 17011531
    [Abstract] [Full Text] [Related]

  • 3. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.
    Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):109-19. PubMed ID: 17069795
    [Abstract] [Full Text] [Related]

  • 4. 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
    Tapia I, Alonso-Cires L, López-Tudanca PL, Mosquera R, Labeaga L, Innerárity A, Orjales A.
    J Med Chem; 1999 Jul 29; 42(15):2870-80. PubMed ID: 10425096
    [Abstract] [Full Text] [Related]

  • 5. In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor.
    Mikami T, Komada T, Sugimoto H, Suzuki K, Ohmi T, Kimura N, Naganeo R, Nakata E, Nakatani K, Toga T, Eda H, Sakakibara M.
    Eur J Pharmacol; 2009 May 01; 609(1-3):5-12. PubMed ID: 19285067
    [Abstract] [Full Text] [Related]

  • 6. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
    Glennon JC, Van Scharrenburg G, Ronken E, Hesselink MB, Reinders JH, Van Der Neut M, Long SK, Feenstra RW, McCreary AC.
    Synapse; 2006 Dec 15; 60(8):599-608. PubMed ID: 17001660
    [Abstract] [Full Text] [Related]

  • 7. New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.
    Hinschberger A, Butt S, Lelong V, Boulouard M, Dumuis A, Dauphin F, Bureau R, Pfeiffer B, Renard P, Rault S.
    J Med Chem; 2003 Jan 02; 46(1):138-47. PubMed ID: 12502367
    [Abstract] [Full Text] [Related]

  • 8. Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies.
    Ray AM, Kelsell RE, Houp JA, Kelly FM, Medhurst AD, Cox HM, Calver AR.
    Eur J Pharmacol; 2009 Feb 14; 604(1-3):1-11. PubMed ID: 19100256
    [Abstract] [Full Text] [Related]

  • 9. Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease.
    Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD.
    Neuroscience; 2004 Feb 14; 129(1):49-54. PubMed ID: 15489027
    [Abstract] [Full Text] [Related]

  • 10. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

  • 11. 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs.
    Mikami T, Ochi Y, Suzuki K, Saito T, Sugie Y, Sakakibara M.
    J Pharmacol Exp Ther; 2008 Apr 16; 325(1):190-9. PubMed ID: 18198343
    [Abstract] [Full Text] [Related]

  • 12. Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating.
    Schreiber R, Vivian J, Hedley L, Szczepanski K, Secchi RL, Zuzow M, van Laarhoven S, Moreau JL, Martin JR, Sik A, Blokland A.
    Eur Neuropsychopharmacol; 2007 Mar 16; 17(4):277-88. PubMed ID: 16989988
    [Abstract] [Full Text] [Related]

  • 13. The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.
    Millan MJ, Gobert A, Roux S, Porsolt R, Meneses A, Carli M, Di Cara B, Jaffard R, Rivet JM, Lestage P, Mocaer E, Peglion JL, Dekeyne A.
    J Pharmacol Exp Ther; 2004 Oct 16; 311(1):190-203. PubMed ID: 15146031
    [Abstract] [Full Text] [Related]

  • 14. Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).
    Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, Saab AL, Smith DL, Sullivan K, Rizzo SJ, Tio C, Zhang MY, Schechter LE.
    J Pharmacol Exp Ther; 2008 Apr 16; 325(1):134-45. PubMed ID: 18182558
    [Abstract] [Full Text] [Related]

  • 15. Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities.
    Schaffhauser H, Mathiasen JR, Dicamillo A, Huffman MJ, Lu LD, McKenna BA, Qian J, Marino MJ.
    Biochem Pharmacol; 2009 Oct 15; 78(8):1035-42. PubMed ID: 19549510
    [Abstract] [Full Text] [Related]

  • 16. 5-HT4 receptor agonism in the five-choice serial reaction time task.
    Hille C, Bate S, Davis J, Gonzalez MI.
    Behav Brain Res; 2008 Dec 16; 195(1):180-6. PubMed ID: 18765258
    [Abstract] [Full Text] [Related]

  • 17. Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats.
    Tamburella A, Micale V, Navarria A, Drago F.
    Prog Neuropsychopharmacol Biol Psychiatry; 2009 Oct 01; 33(7):1205-10. PubMed ID: 19596038
    [Abstract] [Full Text] [Related]

  • 18. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.
    Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT.
    Neuropharmacology; 2011 Oct 01; 61(1-2):69-79. PubMed ID: 21392515
    [Abstract] [Full Text] [Related]

  • 19. Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization.
    Schwarz RD, Callahan MJ, Coughenour LL, Dickerson MR, Kinsora JJ, Lipinski WJ, Raby CA, Spencer CJ, Tecle H.
    J Pharmacol Exp Ther; 1999 Nov 01; 291(2):812-22. PubMed ID: 10525104
    [Abstract] [Full Text] [Related]

  • 20. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.
    Harada K, Aota M, Inoue T, Matsuda R, Mihara T, Yamaji T, Ishibashi K, Matsuoka N.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):171-84. PubMed ID: 17074317
    [Abstract] [Full Text] [Related]

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