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266 related items for PubMed ID: 12130740

  • 1. Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity.
    Duysen EG, Bartels CF, Lockridge O.
    J Pharmacol Exp Ther; 2002 Aug; 302(2):751-8. PubMed ID: 12130740
    [Abstract] [Full Text] [Related]

  • 2. Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers.
    Li H, Schopfer LM, Masson P, Lockridge O.
    Biochem J; 2008 Apr 15; 411(2):425-32. PubMed ID: 18076380
    [Abstract] [Full Text] [Related]

  • 3. Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.
    Mikami LR, Wieseler S, Souza RL, Schopfer LM, Nachon F, Lockridge O, Chautard-Freire-Maia EA.
    Pharmacogenet Genomics; 2008 Mar 15; 18(3):213-8. PubMed ID: 18300943
    [Abstract] [Full Text] [Related]

  • 4. Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers.
    Altamirano CV, Lockridge O.
    Biochemistry; 1999 Oct 05; 38(40):13414-22. PubMed ID: 10529218
    [Abstract] [Full Text] [Related]

  • 5. Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase.
    Chilukuri N, Sun W, Naik RS, Parikh K, Tang L, Doctor BP, Saxena A.
    Chem Biol Interact; 2008 Sep 25; 175(1-3):255-60. PubMed ID: 18603232
    [Abstract] [Full Text] [Related]

  • 6. Tetramerization domain of human butyrylcholinesterase is at the C-terminus.
    Blong RM, Bedows E, Lockridge O.
    Biochem J; 1997 Nov 01; 327 ( Pt 3)(Pt 3):747-57. PubMed ID: 9581552
    [Abstract] [Full Text] [Related]

  • 7. Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.
    Mikami LR, Wieseler S, Souza RL, Schopfer LM, Lockridge O, Chautard-Freire-Maia EA.
    Pharmacogenet Genomics; 2007 Sep 01; 17(9):681-5. PubMed ID: 17700357
    [Abstract] [Full Text] [Related]

  • 8. A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.
    Lockridge O, Blong RM, Masson P, Froment MT, Millard CB, Broomfield CA.
    Biochemistry; 1997 Jan 28; 36(4):786-95. PubMed ID: 9020776
    [Abstract] [Full Text] [Related]

  • 9. Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase.
    Chilukuri N, Parikh K, Sun W, Naik R, Tipparaju P, Doctor BP, Saxena A.
    Chem Biol Interact; 2005 Dec 15; 157-158():115-21. PubMed ID: 16253215
    [Abstract] [Full Text] [Related]

  • 10. Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats.
    Gao Y, Brimijoin S.
    Chem Biol Interact; 2005 Dec 15; 157-158():97-103. PubMed ID: 16243302
    [Abstract] [Full Text] [Related]

  • 11. Therapeutic use of butyrylcholinesterase for cocaine intoxication.
    Mattes CE, Lynch TJ, Singh A, Bradley RM, Kellaris PA, Brady RO, Dretchen KL.
    Toxicol Appl Pharmacol; 1997 Aug 15; 145(2):372-80. PubMed ID: 9266811
    [Abstract] [Full Text] [Related]

  • 12. Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
    Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S.
    J Pharmacol Exp Ther; 2002 Aug 15; 302(2):710-6. PubMed ID: 12130735
    [Abstract] [Full Text] [Related]

  • 13. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.
    Chilukuri N, Duysen EG, Parikh K, diTargiani R, Doctor BP, Lockridge O, Saxena A.
    Mol Pharmacol; 2009 Sep 15; 76(3):612-7. PubMed ID: 19542320
    [Abstract] [Full Text] [Related]

  • 14. Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.
    Duysen EG, Lockridge O.
    Drug Metab Dispos; 2011 Aug 15; 39(8):1321-3. PubMed ID: 21540357
    [Abstract] [Full Text] [Related]

  • 15. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
    Xue L, Ko MC, Tong M, Yang W, Hou S, Fang L, Liu J, Zheng F, Woods JH, Tai HH, Zhan CG.
    Mol Pharmacol; 2011 Feb 15; 79(2):290-7. PubMed ID: 20971807
    [Abstract] [Full Text] [Related]

  • 16. Increased organophosphate scavenging in a butyrylcholinesterase mutant.
    Geyer BC, Woods RR, Mor TS.
    Chem Biol Interact; 2008 Sep 25; 175(1-3):376-9. PubMed ID: 18514178
    [Abstract] [Full Text] [Related]

  • 17. The role of Phe329 in binding of cationic triarylmethane dyes to human butyrylcholinesterase.
    Biberoglu K, Tacal Ö, Akbulut H.
    Arch Biochem Biophys; 2011 Jul 25; 511(1-2):64-8. PubMed ID: 21530486
    [Abstract] [Full Text] [Related]

  • 18. The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.
    Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP.
    Biochemistry; 1998 Oct 27; 37(43):15086-96. PubMed ID: 9790671
    [Abstract] [Full Text] [Related]

  • 19. Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.
    Yang W, Xue L, Fang L, Chen X, Zhan CG.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):148-52. PubMed ID: 20060817
    [Abstract] [Full Text] [Related]

  • 20. Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.
    Xue L, Hou S, Tong M, Fang L, Chen X, Jin Z, Tai HH, Zheng F, Zhan CG.
    Biochem J; 2013 Aug 01; 453(3):447-54. PubMed ID: 23849058
    [Abstract] [Full Text] [Related]

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