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324 related items for PubMed ID: 12134947

  • 1. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):780-6. PubMed ID: 12134947
    [Abstract] [Full Text] [Related]

  • 2. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):787-93. PubMed ID: 12134948
    [Abstract] [Full Text] [Related]

  • 3. A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
    Ouyang H, Tang F, Siahaan TJ, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):794-801. PubMed ID: 12134949
    [Abstract] [Full Text] [Related]

  • 4. Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
    Tang F, Horie K, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):773-9. PubMed ID: 12134946
    [Abstract] [Full Text] [Related]

  • 5. Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan; 98(1):337-48. PubMed ID: 18537149
    [Abstract] [Full Text] [Related]

  • 6. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    Tang F, Horie K, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):765-72. PubMed ID: 12134945
    [Abstract] [Full Text] [Related]

  • 7. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A, Gudmundsson OS, Friis GJ, Siahaan TJ, Borchardt RT.
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
    [Abstract] [Full Text] [Related]

  • 8. Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
    Horie K, Tang F, Borchardt RT.
    Pharm Res; 2003 Feb; 20(2):161-8. PubMed ID: 12636153
    [Abstract] [Full Text] [Related]

  • 9. Transport characteristics of tryptanthrin and its inhibitory effect on P-gp and MRP2 in Caco-2 cells.
    Zhu X, Zhang X, Ma G, Yan J, Wang H, Yang Q.
    J Pharm Pharm Sci; 2011 Feb; 14(3):325-35. PubMed ID: 21824448
    [Abstract] [Full Text] [Related]

  • 10. Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.
    Taub ME, Podila L, Ely D, Almeida I.
    Drug Metab Dispos; 2005 Nov; 33(11):1679-87. PubMed ID: 16093365
    [Abstract] [Full Text] [Related]

  • 11. A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP.
    Xiao L, Yi T, Chen M, Lam CW, Zhou H.
    Eur J Pharm Sci; 2016 Oct 10; 93():456-67. PubMed ID: 27586020
    [Abstract] [Full Text] [Related]

  • 12. Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers.
    Tang F, Ouyang H, Yang JZ, Borchardt RT.
    J Pharm Sci; 2004 May 10; 93(5):1185-94. PubMed ID: 15067695
    [Abstract] [Full Text] [Related]

  • 13. Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
    Chen EC, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, Zhang S, Jorski J, Gaffney K, Umemoto KK, Salphati L.
    Mol Pharm; 2018 Nov 05; 15(11):5103-5113. PubMed ID: 30222362
    [Abstract] [Full Text] [Related]

  • 14. In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs.
    Yu L, Shen Q, Zhou Q, Jiang H, Bi H, Huang M, Zhou H, Zeng S.
    J Ethnopharmacol; 2013 Nov 25; 150(2):485-91. PubMed ID: 24036064
    [Abstract] [Full Text] [Related]

  • 15. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
    Ye D, Harder A, Fang Z, Weinheimer M, Laplanche L, Mezler M.
    Pharm Res; 2020 Sep 11; 37(10):194. PubMed ID: 32918191
    [Abstract] [Full Text] [Related]

  • 16. Functional characterization of peptide transporters in MDCKII-MDR1 cell line as a model for oral absorption studies.
    Agarwal S, Jain R, Pal D, Mitra AK.
    Int J Pharm; 2007 Mar 06; 332(1-2):147-52. PubMed ID: 17097248
    [Abstract] [Full Text] [Related]

  • 17. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT.
    Pharm Res; 1999 Jan 06; 16(1):16-23. PubMed ID: 9950273
    [Abstract] [Full Text] [Related]

  • 18. Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan 06; 98(1):349-61. PubMed ID: 18537150
    [Abstract] [Full Text] [Related]

  • 19. Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.
    Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Liu PQ, Duan W, Chowbay B, Wen JY, Li CG, Zhou SF.
    Curr Drug Metab; 2007 May 06; 8(4):325-40. PubMed ID: 17504222
    [Abstract] [Full Text] [Related]

  • 20. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.
    Zhang Y, Benet LZ.
    Pharm Res; 1998 Oct 06; 15(10):1520-4. PubMed ID: 9794492
    [Abstract] [Full Text] [Related]

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