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306 related items for PubMed ID: 12139970

  • 1. The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.
    Sanna B, Debidda M, Pintus G, Tadolini B, Posadino AM, Bennardini F, Sava G, Ventura C.
    Arch Biochem Biophys; 2002 Jul 15; 403(2):209-18. PubMed ID: 12139970
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation.
    Pintus G, Tadolini B, Posadino AM, Sanna B, Debidda M, Bennardini F, Sava G, Ventura C.
    Eur J Biochem; 2002 Dec 15; 269(23):5861-70. PubMed ID: 12444974
    [Abstract] [Full Text] [Related]

  • 3. NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.
    Debidda M, Sanna B, Cossu A, Posadino AM, Tadolini B, Ventura C, Pintus G.
    Int J Oncol; 2003 Aug 15; 23(2):477-82. PubMed ID: 12851698
    [Abstract] [Full Text] [Related]

  • 4. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S.
    Cancer Res; 2002 Jan 01; 62(1):188-99. PubMed ID: 11782377
    [Abstract] [Full Text] [Related]

  • 5. Requirement for ERK activation in cisplatin-induced apoptosis.
    Wang X, Martindale JL, Holbrook NJ.
    J Biol Chem; 2000 Dec 15; 275(50):39435-43. PubMed ID: 10993883
    [Abstract] [Full Text] [Related]

  • 6. Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.
    Okano J, Rustgi AK.
    J Biol Chem; 2001 Jun 01; 276(22):19555-64. PubMed ID: 11278851
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.
    Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR.
    Nat Cell Biol; 2003 Jul 01; 5(7):647-54. PubMed ID: 12792650
    [Abstract] [Full Text] [Related]

  • 8. Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.
    Söderström TS, Poukkula M, Holmström TH, Heiskanen KM, Eriksson JE.
    J Immunol; 2002 Sep 15; 169(6):2851-60. PubMed ID: 12218097
    [Abstract] [Full Text] [Related]

  • 9. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines.
    Miranda MB, McGuire TF, Johnson DE.
    Leukemia; 2002 Apr 15; 16(4):683-92. PubMed ID: 11960350
    [Abstract] [Full Text] [Related]

  • 10. Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.
    Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Horiuchi M, Ogihara T.
    Hypertension; 2001 Feb 15; 37(2 Pt 2):581-6. PubMed ID: 11230338
    [Abstract] [Full Text] [Related]

  • 11. Sodium orthovanadate potentiates EGCG-induced apoptosis that is dependent on the ERK pathway.
    Choi YJ, Lim SY, Woo JH, Kim YH, Kwon YK, Suh SI, Lee SH, Choi WY, Kim JG, Lee IS, Park JW, Kwon TK.
    Biochem Biophys Res Commun; 2003 May 23; 305(1):176-85. PubMed ID: 12732214
    [Abstract] [Full Text] [Related]

  • 12. Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.
    Fukazawa H, Noguchi K, Murakami Y, Uehara Y.
    Mol Cancer Ther; 2002 Mar 23; 1(5):303-9. PubMed ID: 12489846
    [Abstract] [Full Text] [Related]

  • 13. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 14. Expression pattern and role of a 60-kilodalton progesterone binding protein in regulating granulosa cell apoptosis: involvement of the mitogen-activated protein kinase cascade.
    Peluso JJ, Bremner T, Fernandez G, Pappalardo A, White BA.
    Biol Reprod; 2003 Jan 01; 68(1):122-8. PubMed ID: 12493703
    [Abstract] [Full Text] [Related]

  • 15. Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis.
    Andreka P, Zang J, Dougherty C, Slepak TI, Webster KA, Bishopric NH.
    Circ Res; 2001 Feb 16; 88(3):305-12. PubMed ID: 11179198
    [Abstract] [Full Text] [Related]

  • 16. c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.
    Desbiens KM, Deschesnes RG, Labrie MM, Desfossés Y, Lambert H, Landry J, Bellmann K.
    Biochem J; 2003 Jun 01; 372(Pt 2):631-41. PubMed ID: 12646044
    [Abstract] [Full Text] [Related]

  • 17. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
    Tyagi A, Agarwal R, Agarwal C.
    Oncogene; 2003 Mar 06; 22(9):1302-16. PubMed ID: 12618755
    [Abstract] [Full Text] [Related]

  • 18. Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.
    Yu C, Wang S, Dent P, Grant S.
    Mol Pharmacol; 2001 Jul 06; 60(1):143-54. PubMed ID: 11408609
    [Abstract] [Full Text] [Related]

  • 19. Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
    Rice PL, Washington M, Schleman S, Beard KS, Driggers LJ, Ahnen DJ.
    Cancer Res; 2003 Feb 01; 63(3):616-20. PubMed ID: 12566304
    [Abstract] [Full Text] [Related]

  • 20. p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.
    Li SP, Junttila MR, Han J, Kähäri VM, Westermarck J.
    Cancer Res; 2003 Jul 01; 63(13):3473-7. PubMed ID: 12839928
    [Abstract] [Full Text] [Related]

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