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305 related items for PubMed ID: 12166947

  • 1. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.
    Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M.
    J Med Chem; 2002 Aug 15; 45(17):3746-54. PubMed ID: 12166947
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
    Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ.
    J Med Chem; 2007 Jun 28; 50(13):3138-42. PubMed ID: 17539621
    [Abstract] [Full Text] [Related]

  • 3. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.
    Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL.
    J Pharmacol Exp Ther; 2003 Feb 28; 304(2):827-32. PubMed ID: 12538839
    [Abstract] [Full Text] [Related]

  • 4. Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
    Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ.
    Life Sci; 1997 Feb 28; 60(15):1263-9. PubMed ID: 9096243
    [Abstract] [Full Text] [Related]

  • 5. Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
    Salvadori S, Balboni G, Guerrini R, Tomatis R, Bianchi C, Bryant SD, Cooper PS, Lazarus LH.
    J Med Chem; 1997 Sep 12; 40(19):3100-8. PubMed ID: 9301674
    [Abstract] [Full Text] [Related]

  • 6. Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.
    Berezowska I, Chung NN, Lemieux C, Wilkes BC, Schiller PW.
    J Med Chem; 2007 Mar 22; 50(6):1414-7. PubMed ID: 17315860
    [Abstract] [Full Text] [Related]

  • 7. Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).
    Mosberg HI, Lomize AL, Wang C, Kroona H, Heyl DL, Sobczyk-Kojiro K, Ma W, Mousigian C, Porreca F.
    J Med Chem; 1994 Dec 09; 37(25):4371-83. PubMed ID: 7996549
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
    Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB.
    J Med Chem; 1998 Jul 16; 41(15):2872-81. PubMed ID: 9667975
    [Abstract] [Full Text] [Related]

  • 9. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
    Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ.
    J Med Chem; 2007 Nov 01; 50(22):5528-32. PubMed ID: 17927164
    [Abstract] [Full Text] [Related]

  • 10. Conformationally restricted deltorphin analogues.
    Schiller PW, Weltrowska G, Nguyen TM, Wilkes BC, Chung NN, Lemieux C.
    J Med Chem; 1992 Oct 16; 35(21):3956-61. PubMed ID: 1331451
    [Abstract] [Full Text] [Related]

  • 11. Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
    Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI.
    J Med Chem; 1997 Nov 21; 40(24):3957-62. PubMed ID: 9397176
    [Abstract] [Full Text] [Related]

  • 12. 2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides.
    Sasaki Y, Sasaki A, Ariizumi T, Igari Y, Sato K, Kohara H, Niizuma H, Ambo A.
    Biol Pharm Bull; 2004 Feb 21; 27(2):244-7. PubMed ID: 14758045
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
    Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ.
    J Med Chem; 2007 Jun 14; 50(12):2779-86. PubMed ID: 17516639
    [Abstract] [Full Text] [Related]

  • 14. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.
    Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ.
    J Med Chem; 2012 Apr 12; 55(7):3027-35. PubMed ID: 22394120
    [Abstract] [Full Text] [Related]

  • 15. Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.
    Corbett AD, Gillan MG, Kosterlitz HW, McKnight AT, Paterson SJ, Robson LE.
    Br J Pharmacol; 1984 Sep 12; 83(1):271-9. PubMed ID: 6091824
    [Abstract] [Full Text] [Related]

  • 16. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
    Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ.
    J Med Chem; 2006 May 18; 49(10):2868-75. PubMed ID: 16686530
    [Abstract] [Full Text] [Related]

  • 17. Opioid profiles of Cys2-containing enkephalin analogues.
    Pencheva N, Milanov P, Vezenkov L, Pajpanova T, Naydenova E.
    Eur J Pharmacol; 2004 Sep 13; 498(1-3):249-56. PubMed ID: 15364002
    [Abstract] [Full Text] [Related]

  • 18. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
    Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ.
    J Med Chem; 2008 Mar 13; 51(5):1369-76. PubMed ID: 18266313
    [Abstract] [Full Text] [Related]

  • 19. Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
    Fujita Y, Tsuda Y, Li T, Motoyama T, Takahashi M, Shimizu Y, Yokoi T, Sasaki Y, Ambo A, Kita A, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y.
    J Med Chem; 2004 Jul 01; 47(14):3591-9. PubMed ID: 15214786
    [Abstract] [Full Text] [Related]

  • 20. Design of opioid peptides for a potential delta-receptor affinity label function: comparison with the mu-specific Tyr-D-Ala-Gly-(Me)Phe-chloromethyl ketone.
    Rónai AZ, Hepp J, Magyar A, Borsodi A, Medzihradszky K.
    Pharmacology; 1994 Aug 01; 49(2):121-31. PubMed ID: 7972321
    [Abstract] [Full Text] [Related]

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