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325 related items for PubMed ID: 12167642

  • 1. Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
    Dhanak D, Duffy KJ, Johnston VK, Lin-Goerke J, Darcy M, Shaw AN, Gu B, Silverman C, Gates AT, Nonnemacher MR, Earnshaw DL, Casper DJ, Kaura A, Baker A, Greenwood C, Gutshall LL, Maley D, DelVecchio A, Macarron R, Hofmann GA, Alnoah Z, Cheng HY, Chan G, Khandekar S, Keenan RM, Sarisky RT.
    J Biol Chem; 2002 Oct 11; 277(41):38322-7. PubMed ID: 12167642
    [Abstract] [Full Text] [Related]

  • 2. A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.
    Ranjith-Kumar CT, Wen Y, Baxter N, Bhardwaj K, Cheng Kao C.
    PLoS One; 2011 Oct 11; 6(7):e22575. PubMed ID: 21799903
    [Abstract] [Full Text] [Related]

  • 3. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
    McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G.
    Nucleic Acids Res; 2004 Oct 11; 32(2):422-31. PubMed ID: 14739234
    [Abstract] [Full Text] [Related]

  • 4. Interference of HCV replication by cell penetrable human monoclonal scFv specific to NS5B polymerase.
    Thueng-in K, Thanongsaksrikul J, Jittavisutthikul S, Seesuay W, Chulanetra M, Sakolvaree Y, Srimanote P, Chaicumpa W.
    MAbs; 2014 Oct 11; 6(5):1327-39. PubMed ID: 25517317
    [Abstract] [Full Text] [Related]

  • 5. Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
    Nguyen TT, Gates AT, Gutshall LL, Johnston VK, Gu B, Duffy KJ, Sarisky RT.
    Antimicrob Agents Chemother; 2003 Nov 11; 47(11):3525-30. PubMed ID: 14576112
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.
    Ma H, Leveque V, De Witte A, Li W, Hendricks T, Clausen SM, Cammack N, Klumpp K.
    Virology; 2005 Feb 05; 332(1):8-15. PubMed ID: 15661135
    [Abstract] [Full Text] [Related]

  • 7. Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.
    Gu B, Johnston VK, Gutshall LL, Nguyen TT, Gontarek RR, Darcy MG, Tedesco R, Dhanak D, Duffy KJ, Kao CC, Sarisky RT.
    J Biol Chem; 2003 May 09; 278(19):16602-7. PubMed ID: 12554734
    [Abstract] [Full Text] [Related]

  • 8. Evidence for Internal Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B In Cellulo.
    Schult P, Nattermann M, Lauber C, Seitz S, Lohmann V.
    J Virol; 2019 Oct 01; 93(19):. PubMed ID: 31315989
    [Abstract] [Full Text] [Related]

  • 9. Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor.
    Chen Y, Bopda-Waffo A, Basu A, Krishnan R, Silberstein E, Taylor DR, Talele TT, Arora P, Kaushik-Basu N.
    Antivir Chem Chemother; 2009 Sep 25; 20(1):19-36. PubMed ID: 19794229
    [Abstract] [Full Text] [Related]

  • 10. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
    Devogelaere B, Berke JM, Vijgen L, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Nyanguile O, Tahri A, Amssoms K, Lenz O, Cummings MD, Clayton RF, Vendeville S, Raboisson P, Simmen KA, Fanning GC, Lin TI.
    Antimicrob Agents Chemother; 2012 Sep 25; 56(9):4676-84. PubMed ID: 22710121
    [Abstract] [Full Text] [Related]

  • 11. Phosphorylation of hepatitis C virus RNA polymerases ser29 and ser42 by protein kinase C-related kinase 2 regulates viral RNA replication.
    Han SH, Kim SJ, Kim EJ, Kim TE, Moon JS, Kim GW, Lee SH, Cho K, Yoo JS, Son WS, Rhee JK, Han SH, Oh JW.
    J Virol; 2014 Oct 25; 88(19):11240-52. PubMed ID: 25031343
    [Abstract] [Full Text] [Related]

  • 12. Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
    Nikonov A, Juronen E, Ustav M.
    J Biol Chem; 2008 Aug 29; 283(35):24089-102. PubMed ID: 18574240
    [Abstract] [Full Text] [Related]

  • 13. Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.
    Cheney IW, Naim S, Lai VC, Dempsey S, Bellows D, Walker MP, Shim JH, Horscroft N, Hong Z, Zhong W.
    Virology; 2002 Jun 05; 297(2):298-306. PubMed ID: 12083828
    [Abstract] [Full Text] [Related]

  • 14. 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
    Nyanguile O, Pauwels F, Van den Broeck W, Boutton CW, Quirynen L, Ivens T, van der Helm L, Vandercruyssen G, Mostmans W, Delouvroy F, Dehertogh P, Cummings MD, Bonfanti JF, Simmen KA, Raboisson P.
    Antimicrob Agents Chemother; 2008 Dec 05; 52(12):4420-31. PubMed ID: 18852280
    [Abstract] [Full Text] [Related]

  • 15. The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo.
    Lee KJ, Choi J, Ou JH, Lai MM.
    J Virol; 2004 Apr 05; 78(7):3797-802. PubMed ID: 15016899
    [Abstract] [Full Text] [Related]

  • 16. Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
    Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF.
    Antimicrob Agents Chemother; 2004 Dec 05; 48(12):4813-21. PubMed ID: 15561861
    [Abstract] [Full Text] [Related]

  • 17. Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
    Ahmed-Belkacem A, Ahnou N, Barbotte L, Wychowski C, Pallier C, Brillet R, Pohl RT, Pawlotsky JM.
    Gastroenterology; 2010 Mar 05; 138(3):1112-22. PubMed ID: 19962982
    [Abstract] [Full Text] [Related]

  • 18. Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.
    Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL.
    J Biol Chem; 2005 Nov 25; 280(47):39260-7. PubMed ID: 16188890
    [Abstract] [Full Text] [Related]

  • 19. NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
    Bessa LM, Launay H, Dujardin M, Cantrelle FX, Lippens G, Landrieu I, Schneider R, Hanoulle X.
    J Biol Chem; 2017 Nov 03; 292(44):18024-18043. PubMed ID: 28912275
    [Abstract] [Full Text] [Related]

  • 20. Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
    Herlihy KJ, Graham JP, Kumpf R, Patick AK, Duggal R, Shi ST.
    Antimicrob Agents Chemother; 2008 Oct 03; 52(10):3523-31. PubMed ID: 18694956
    [Abstract] [Full Text] [Related]

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