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136 related items for PubMed ID: 12170777

  • 1. Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.
    Qiao L, Yacoub A, McKinstry R, Park JS, Caron R, Fisher PB, Hagan MP, Grant S, Dent P.
    Cancer Biol Ther; 2002; 1(2):168-76. PubMed ID: 12170777
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  • 2. Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
    McKinstry R, Qiao L, Yacoub A, Dai Y, Decker R, Holt S, Hagan MP, Grant S, Dent P.
    Cancer Biol Ther; 2002; 1(3):243-53. PubMed ID: 12432271
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  • 3. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.
    Park JS, Carter S, Reardon DB, Schmidt-Ullrich R, Dent P, Fisher PB.
    Mol Biol Cell; 1999 Dec; 10(12):4231-46. PubMed ID: 10588655
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  • 4. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S.
    Cancer Res; 2002 Jan 01; 62(1):188-99. PubMed ID: 11782377
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  • 5. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
    Dent P, Reardon DB, Park JS, Bowers G, Logsdon C, Valerie K, Schmidt-Ullrich R.
    Mol Biol Cell; 1999 Aug 01; 10(8):2493-506. PubMed ID: 10436007
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  • 6. MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
    Yacoub A, Mitchell C, Hong Y, Gopalkrishnan RV, Su ZZ, Gupta P, Sauane M, Lebedeva IV, Curiel DT, Mahasreshti PJ, Rosenfeld MR, Broaddus WC, James CD, Grant S, Fisher PB, Dent P.
    Cancer Biol Ther; 2004 Aug 01; 3(8):739-51. PubMed ID: 15197348
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  • 10. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
    Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P.
    Mol Biol Cell; 2001 Sep 01; 12(9):2629-45. PubMed ID: 11553704
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  • 11. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
    Tyagi A, Agarwal R, Agarwal C.
    Oncogene; 2003 Mar 06; 22(9):1302-16. PubMed ID: 12618755
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  • 17. Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways.
    Kamiguti AS, Harris RJ, Slupsky JR, Baker PK, Cawley JC, Zuzel M.
    Oncogene; 2003 Apr 17; 22(15):2272-84. PubMed ID: 12700663
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  • 18. MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
    Yacoub A, Gilfor D, Hawkins W, Park MA, Hanna D, Hagan MP, Curiel DT, Fisher PB, Grant S, Dent P.
    Cancer Biol Ther; 2006 Oct 17; 5(10):1332-9. PubMed ID: 16957420
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  • 19. Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.
    Pelletier JP, Fernandes JC, Jovanovic DV, Reboul P, Martel-Pelletier J.
    J Rheumatol; 2001 Nov 17; 28(11):2509-19. PubMed ID: 11708426
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