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140 related items for PubMed ID: 12171915

  • 1. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
    Chen YR, Han J, Kori R, Kong AN, Tan TH.
    J Biol Chem; 2002 Oct 18; 277(42):39334-42. PubMed ID: 12171915
    [Abstract] [Full Text] [Related]

  • 2. Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.
    Xiao D, Singh SV.
    Cancer Res; 2002 Jul 01; 62(13):3615-9. PubMed ID: 12097262
    [Abstract] [Full Text] [Related]

  • 3. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.
    Chen YR, Wang W, Kong AN, Tan TH.
    J Biol Chem; 1998 Jan 16; 273(3):1769-75. PubMed ID: 9430725
    [Abstract] [Full Text] [Related]

  • 4. The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.
    Hu R, Kim BR, Chen C, Hebbar V, Kong AN.
    Carcinogenesis; 2003 Aug 16; 24(8):1361-7. PubMed ID: 12819185
    [Abstract] [Full Text] [Related]

  • 5. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
    Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.
    Carcinogenesis; 2006 Mar 16; 27(3):437-45. PubMed ID: 16272172
    [Abstract] [Full Text] [Related]

  • 6. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
    Xu C, Yuan X, Pan Z, Shen G, Kim JH, Yu S, Khor TO, Li W, Ma J, Kong AN.
    Mol Cancer Ther; 2006 Aug 16; 5(8):1918-26. PubMed ID: 16928811
    [Abstract] [Full Text] [Related]

  • 7. Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
    Wu SJ, Ng LT, Lin CC.
    Eur J Pharmacol; 2005 Aug 22; 518(2-3):96-106. PubMed ID: 16054126
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.
    Yang YM, Conaway CC, Chiao JW, Wang CX, Amin S, Whysner J, Dai W, Reinhardt J, Chung FL.
    Cancer Res; 2002 Jan 01; 62(1):2-7. PubMed ID: 11782348
    [Abstract] [Full Text] [Related]

  • 9. c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.
    Vivo C, Liu W, Broaddus VC.
    J Biol Chem; 2003 Jul 11; 278(28):25461-7. PubMed ID: 12707267
    [Abstract] [Full Text] [Related]

  • 10. Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
    Xiao D, Choi S, Lee YJ, Singh SV.
    Mol Carcinog; 2005 Jul 11; 43(3):130-40. PubMed ID: 15880419
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.
    Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ.
    J Biol Chem; 2004 Aug 27; 279(35):36490-6. PubMed ID: 15218033
    [Abstract] [Full Text] [Related]

  • 12. Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation.
    Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L.
    Gynecol Oncol; 2006 Oct 27; 103(1):261-70. PubMed ID: 16624391
    [Abstract] [Full Text] [Related]

  • 13. Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.
    Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S.
    J Biol Chem; 2002 Nov 15; 277(46):43648-58. PubMed ID: 12221076
    [Abstract] [Full Text] [Related]

  • 14. Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.
    Yu R, Jiao JJ, Duh JL, Tan TH, Kong AN.
    Cancer Res; 1996 Jul 01; 56(13):2954-9. PubMed ID: 8674048
    [Abstract] [Full Text] [Related]

  • 15. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.
    Saeki K, Kobayashi N, Inazawa Y, Zhang H, Nishitoh H, Ichijo H, Saeki K, Isemura M, Yuo A.
    Biochem J; 2002 Dec 15; 368(Pt 3):705-20. PubMed ID: 12206715
    [Abstract] [Full Text] [Related]

  • 16. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
    Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG.
    J Biol Chem; 2003 Sep 05; 278(36):33753-62. PubMed ID: 12824193
    [Abstract] [Full Text] [Related]

  • 17. c-Jun NH2-terminal kinase-dependent Fas activation contributes to etoposide-induced apoptosis in p53-mutated prostate cancer cells.
    Shimada K, Nakamura M, Ishida E, Kishi M, Yonehara S, Konishi N.
    Prostate; 2003 Jun 01; 55(4):265-80. PubMed ID: 12712406
    [Abstract] [Full Text] [Related]

  • 18. Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.
    Wang X, Govind S, Sajankila SP, Mi L, Roy R, Chung FL.
    Mol Nutr Food Res; 2011 Oct 01; 55(10):1572-81. PubMed ID: 21595016
    [Abstract] [Full Text] [Related]

  • 19. The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.
    Pullar JM, Thomson SJ, King MJ, Turnbull CI, Midwinter RG, Hampton MB.
    Carcinogenesis; 2004 May 01; 25(5):765-72. PubMed ID: 14729592
    [Abstract] [Full Text] [Related]

  • 20. c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.
    Yao S, Zhang Y, Li J.
    Mol Carcinog; 2006 Aug 01; 45(8):605-12. PubMed ID: 16652374
    [Abstract] [Full Text] [Related]

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