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1877 related items for PubMed ID: 12172553

  • 1. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
    Inoki K, Li Y, Zhu T, Wu J, Guan KL.
    Nat Cell Biol; 2002 Sep; 4(9):648-57. PubMed ID: 12172553
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  • 2. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
    Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J.
    Proc Natl Acad Sci U S A; 2002 Oct 15; 99(21):13571-6. PubMed ID: 12271141
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  • 6. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
    Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R.
    J Cell Biol; 2002 Oct 28; 159(2):217-24. PubMed ID: 12403809
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  • 7. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
    Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.
    Proc Natl Acad Sci U S A; 2004 Sep 14; 101(37):13489-94. PubMed ID: 15342917
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  • 8. Tumour suppressors hamartin and tuberin: intracellular signalling.
    Krymskaya VP.
    Cell Signal; 2003 Aug 14; 15(8):729-39. PubMed ID: 12781866
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  • 13. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.
    Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ.
    J Neuropathol Exp Neurol; 2004 Dec 14; 63(12):1236-42. PubMed ID: 15624760
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  • 15. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions.
    Han S, Santos TM, Puga A, Roy J, Thiele EA, McCollin M, Stemmer-Rachamimov A, Ramesh V.
    Cancer Res; 2004 Feb 01; 64(3):812-6. PubMed ID: 14871804
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  • 16. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
    Kwiatkowski DJ.
    Cancer Biol Ther; 2003 Feb 01; 2(5):471-6. PubMed ID: 14614311
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  • 17. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
    Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N.
    Genes Dev; 1998 Feb 15; 12(4):502-13. PubMed ID: 9472019
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  • 18. Akt regulates growth by directly phosphorylating Tsc2.
    Potter CJ, Pedraza LG, Xu T.
    Nat Cell Biol; 2002 Sep 15; 4(9):658-65. PubMed ID: 12172554
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  • 19. Tuberous sclerosis: from tubers to mTOR.
    Kwiatkowski DJ.
    Ann Hum Genet; 2003 Jan 15; 67(Pt 1):87-96. PubMed ID: 12556239
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  • 20. Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins.
    Nellist M, Goedbloed MA, Halley DJ.
    Biochem Soc Trans; 2003 Jun 15; 31(Pt 3):587-91. PubMed ID: 12773161
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