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169 related items for PubMed ID: 12177808

  • 1. Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.
    Playle LC, Hicks DJ, Qualtrough D, Paraskeva C.
    Br J Cancer; 2002 Jul 29; 87(3):352-8. PubMed ID: 12177808
    [Abstract] [Full Text] [Related]

  • 2. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.
    J Natl Cancer Inst; 1996 Jul 17; 88(14):956-65. PubMed ID: 8667426
    [Abstract] [Full Text] [Related]

  • 3. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y.
    Cancer Res; 2002 Oct 15; 62(20):5743-8. PubMed ID: 12384533
    [Abstract] [Full Text] [Related]

  • 4. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A, Kohn EA, Brown MK, Rathman J, Livingstone M, Blank DH, Gribble GW.
    Mol Cancer Ther; 2002 Oct 15; 1(12):1067-78. PubMed ID: 12481430
    [Abstract] [Full Text] [Related]

  • 5. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.
    Bunch RT, Eastman A.
    Clin Cancer Res; 1996 May 15; 2(5):791-7. PubMed ID: 9816232
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines.
    Lee SI, Brown MK, Eastman A.
    Biochem Pharmacol; 1999 Dec 01; 58(11):1713-21. PubMed ID: 10571245
    [Abstract] [Full Text] [Related]

  • 7. [Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].
    Hui ZG, Li YX, Yang WZ, Wu JX, Yu ZH.
    Ai Zheng; 2003 Jan 01; 22(1):6-10. PubMed ID: 12561427
    [Abstract] [Full Text] [Related]

  • 8. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
    Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN.
    Cancer Res; 2000 Apr 15; 60(8):2108-12. PubMed ID: 10786669
    [Abstract] [Full Text] [Related]

  • 9. [Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
    Hui ZG, Li YX, Yang WZ, Yu ZH.
    Ai Zheng; 2005 Jan 15; 24(1):1-6. PubMed ID: 15642191
    [Abstract] [Full Text] [Related]

  • 10. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN, Schwartz GK.
    Cancer Res; 2004 Sep 15; 64(18):6635-44. PubMed ID: 15374978
    [Abstract] [Full Text] [Related]

  • 11. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG, Cao CX, Pommier Y.
    Acta Pharmacol Sin; 2004 Jun 15; 25(6):756-62. PubMed ID: 15169628
    [Abstract] [Full Text] [Related]

  • 12. Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine (UCN-01) in human lung cancer cell lines.
    Kim YM, Jeong IH, Pyo H.
    Int J Radiat Oncol Biol Phys; 2012 Jul 01; 83(3):e399-407. PubMed ID: 22417802
    [Abstract] [Full Text] [Related]

  • 13. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ, Stanbridge EJ, Lao X, Cai Q, Fan ST, Redpath JL.
    Radiat Res; 2007 Dec 01; 168(6):706-15. PubMed ID: 18088187
    [Abstract] [Full Text] [Related]

  • 14. Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells.
    Mack PC, Jones AA, Gustafsson MH, Gandara DR, Gumerlock PH, Goldberg Z.
    Radiat Res; 2004 Dec 01; 162(6):623-34. PubMed ID: 15548112
    [Abstract] [Full Text] [Related]

  • 15. UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
    Yu L, Orlandi L, Wang P, Orr MS, Senderowicz AM, Sausville EA, Silvestrini R, Watanabe N, Piwnica-Worms H, O'Connor PM.
    J Biol Chem; 1998 Dec 11; 273(50):33455-64. PubMed ID: 9837924
    [Abstract] [Full Text] [Related]

  • 16. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
    Cartee L, Sankala H, Davis C, Smith R, Maggio S, Lin PS, Dent P, Grant S.
    Int J Oncol; 2002 Aug 11; 21(2):351-9. PubMed ID: 12118331
    [Abstract] [Full Text] [Related]

  • 17. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    Sugiyama K, Shimizu M, Akiyama T, Tamaoki T, Yamaguchi K, Takahashi R, Eastman A, Akinaga S.
    Int J Cancer; 2000 Mar 01; 85(5):703-9. PubMed ID: 10699952
    [Abstract] [Full Text] [Related]

  • 18. Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.
    Tian H, Faje AT, Lee SL, Jorgensen TJ.
    Neoplasia; 2002 Mar 01; 4(2):171-80. PubMed ID: 11896572
    [Abstract] [Full Text] [Related]

  • 19. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
    Hirose Y, Berger MS, Pieper RO.
    Cancer Res; 2001 Aug 01; 61(15):5843-9. PubMed ID: 11479224
    [Abstract] [Full Text] [Related]

  • 20. [Potentiation of radiosensitivity by staurosporine associated with abrogation of G2 phase arrest].
    Sun XC, Wang JJ, Zhen YS, Shao RG.
    Yao Xue Xue Bao; 2002 Jun 01; 37(6):419-23. PubMed ID: 12579796
    [Abstract] [Full Text] [Related]

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