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273 related items for PubMed ID: 12181445

  • 1. Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine.
    Sampath D, Shi Z, Plunkett W.
    Mol Pharmacol; 2002 Sep; 62(3):680-8. PubMed ID: 12181445
    [Abstract] [Full Text] [Related]

  • 2. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG, Cao CX, Pommier Y.
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [Abstract] [Full Text] [Related]

  • 3. G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation.
    Akiyama T, Sugiyama K, Shimizu M, Tamaoki T, Akinaga S.
    Jpn J Cancer Res; 1999 Dec; 90(12):1364-72. PubMed ID: 10665655
    [Abstract] [Full Text] [Related]

  • 4. Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells.
    Sandhu C, Donovan J, Bhattacharya N, Stampfer M, Worland P, Slingerland J.
    Oncogene; 2000 Nov 09; 19(47):5314-23. PubMed ID: 11103932
    [Abstract] [Full Text] [Related]

  • 5. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
    Guo N, Faller DV, Vaziri C.
    Cell Growth Differ; 2002 Feb 09; 13(2):77-86. PubMed ID: 11864911
    [Abstract] [Full Text] [Related]

  • 6. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
    Akiyama T, Yoshida T, Tsujita T, Shimizu M, Mizukami T, Okabe M, Akinaga S.
    Cancer Res; 1997 Apr 15; 57(8):1495-501. PubMed ID: 9108451
    [Abstract] [Full Text] [Related]

  • 7. Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells.
    Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY.
    Eur J Pharmacol; 2011 Nov 30; 670(2-3):356-64. PubMed ID: 21958871
    [Abstract] [Full Text] [Related]

  • 8. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
    Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.
    Genes Dev; 2003 Dec 15; 17(24):3062-74. PubMed ID: 14681206
    [Abstract] [Full Text] [Related]

  • 9. Rapid destruction of human Cdc25A in response to DNA damage.
    Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J.
    Science; 2000 May 26; 288(5470):1425-9. PubMed ID: 10827953
    [Abstract] [Full Text] [Related]

  • 10. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
    Levesque AA, Fanous AA, Poh A, Eastman A.
    Mol Cancer Ther; 2008 Feb 26; 7(2):252-62. PubMed ID: 18281511
    [Abstract] [Full Text] [Related]

  • 11. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.
    Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C.
    J Biol Chem; 2006 Oct 13; 281(41):30631-44. PubMed ID: 16912045
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  • 14. Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
    Sugiyama K, Akiyama T, Shimizu M, Tamaoki T, Courage C, Gescher A, Akinaga S.
    Cancer Res; 1999 Sep 01; 59(17):4406-12. PubMed ID: 10485490
    [Abstract] [Full Text] [Related]

  • 15. Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.
    Wang Q, Worland PJ, Clark JL, Carlson BA, Sausville EA.
    Cell Growth Differ; 1995 Aug 01; 6(8):927-36. PubMed ID: 8547221
    [Abstract] [Full Text] [Related]

  • 16. Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cells.
    Bilodeau JF, Faure R, Piedboeuf B, Mirault ME.
    Exp Cell Res; 2000 May 01; 256(2):347-57. PubMed ID: 10772807
    [Abstract] [Full Text] [Related]

  • 17. p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases.
    Saha P, Eichbaum Q, Silberman ED, Mayer BJ, Dutta A.
    Mol Cell Biol; 1997 Aug 01; 17(8):4338-45. PubMed ID: 9234691
    [Abstract] [Full Text] [Related]

  • 18. Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR.
    Goldstone S, Pavey S, Forrest A, Sinnamon J, Gabrielli B.
    Oncogene; 2001 Feb 22; 20(8):921-32. PubMed ID: 11314027
    [Abstract] [Full Text] [Related]

  • 19. Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition.
    Yoshida M, Feng W, Nishio K, Takahashi M, Heike Y, Saijo N, Wakasugi H, Ikekawa T.
    Int J Cancer; 2001 Nov 01; 94(3):348-52. PubMed ID: 11745413
    [Abstract] [Full Text] [Related]

  • 20. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
    Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN.
    Cancer Res; 2000 Apr 15; 60(8):2108-12. PubMed ID: 10786669
    [Abstract] [Full Text] [Related]

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