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208 related items for PubMed ID: 12182997

  • 1. Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.
    van Bree C, Castro Kreder N, Loves WJ, Franken NA, Peters GJ, Haveman J.
    Int J Radiat Oncol Biol Phys; 2002 Sep 01; 54(1):237-44. PubMed ID: 12182997
    [Abstract] [Full Text] [Related]

  • 2. Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
    Bergman AM, Giaccone G, van Moorsel CJ, Mauritz R, Noordhuis P, Pinedo HM, Peters GJ.
    Eur J Cancer; 2000 Oct 01; 36(15):1974-83. PubMed ID: 11000580
    [Abstract] [Full Text] [Related]

  • 3. Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines.
    van Moorsel CJ, Pinedo HM, Veerman G, Bergman AM, Kuiper CM, Vermorken JB, van der Vijgh WJ, Peters GJ.
    Br J Cancer; 1999 Jun 01; 80(7):981-90. PubMed ID: 10362105
    [Abstract] [Full Text] [Related]

  • 4. Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.
    Al-Madhoun AS, van der Wilt CL, Loves WJ, Padron JM, Eriksson S, Talianidis I, Peters GJ.
    Biochem Pharmacol; 2004 Aug 15; 68(4):601-9. PubMed ID: 15276067
    [Abstract] [Full Text] [Related]

  • 5. Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
    Peters GJ, Van Moorsel CJ, Lakerveld B, Smid K, Noordhuis P, Comijn EC, Weaver D, Willey JC, Voorn D, Van der Vijgh WJ, Pinedo HM.
    Int J Oncol; 2006 Jan 15; 28(1):237-44. PubMed ID: 16328001
    [Abstract] [Full Text] [Related]

  • 6. Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
    Bergman AM, Munch-Petersen B, Jensen PB, Sehested M, Veerman G, Voorn DA, Smid K, Pinedo HM, Peters GJ.
    Biochem Pharmacol; 2001 Jun 01; 61(11):1401-8. PubMed ID: 11331076
    [Abstract] [Full Text] [Related]

  • 7. Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.
    Ruiz van Haperen VW, Veerman G, Eriksson S, Stegmann AP, Peters GJ.
    Semin Oncol; 1995 Aug 01; 22(4 Suppl 11):35-41. PubMed ID: 7481843
    [Abstract] [Full Text] [Related]

  • 8. Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.
    Ruiz van Haperen VW, Veerman G, Eriksson S, Boven E, Stegmann AP, Hermsen M, Vermorken JB, Pinedo HM, Peters GJ.
    Cancer Res; 1994 Aug 01; 54(15):4138-43. PubMed ID: 8033147
    [Abstract] [Full Text] [Related]

  • 9. Synergistic interaction between cisplatin and gemcitabine in vitro.
    Bergman AM, Ruiz van Haperen VW, Veerman G, Kuiper CM, Peters GJ.
    Clin Cancer Res; 1996 Mar 01; 2(3):521-30. PubMed ID: 9816199
    [Abstract] [Full Text] [Related]

  • 10. Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
    Bergman AM, Pinedo HM, Jongsma AP, Brouwer M, Ruiz van Haperen VW, Veerman G, Leyva A, Eriksson S, Peters GJ.
    Biochem Pharmacol; 1999 Feb 15; 57(4):397-406. PubMed ID: 9933028
    [Abstract] [Full Text] [Related]

  • 11. Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells.
    van Bree C, Rodermond H, Leen R, Medema J, van Kuilenburg A.
    Br J Cancer; 2008 Apr 08; 98(7):1226-33. PubMed ID: 18349845
    [Abstract] [Full Text] [Related]

  • 12. Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene.
    Beauséjour CM, Gagnon J, Primeau M, Momparler RL.
    Biochem Biophys Res Commun; 2002 May 24; 293(5):1478-84. PubMed ID: 12054682
    [Abstract] [Full Text] [Related]

  • 13. Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine.
    van Haperen VW, Veerman G, Vermorken JB, Pinedo HM, Peters G.
    Biochem Pharmacol; 1996 Apr 12; 51(7):911-8. PubMed ID: 8651941
    [Abstract] [Full Text] [Related]

  • 14. Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines.
    Van Moorsel CJ, Smid K, Voorn DA, Bergman AM, Pinedo HM, Peters GJ.
    Int J Oncol; 2003 Jan 12; 22(1):201-7. PubMed ID: 12469205
    [Abstract] [Full Text] [Related]

  • 15. The radioenhancement of two human head and neck squamous cell carcinomas by 2'-2' difluorodeoxycytidine (gemcitabine; dFdC) is mediated by an increase in radiation-induced residual chromosome aberrations but not residual DNA DSBs.
    Rosier JF, Michaux L, Ameye G, Cedervall B, Libouton JM, Octave-Prignot M, Verellen-Dumoulin C, Scalliet P, Grégoire V.
    Mutat Res; 2003 Jun 19; 527(1-2):15-26. PubMed ID: 12787910
    [Abstract] [Full Text] [Related]

  • 16. Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro.
    Grégoire V, Rosier JF, De Bast M, Bruniaux M, De Coster B, Octave-Prignot M, Scalliet P.
    Radiother Oncol; 2002 Jun 19; 63(3):329-38. PubMed ID: 12142097
    [Abstract] [Full Text] [Related]

  • 17. Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.
    Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Egawa S, Unno M, Terasaki T.
    Pharm Res; 2012 Jul 19; 29(7):2006-16. PubMed ID: 22419259
    [Abstract] [Full Text] [Related]

  • 18. Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.
    Bierau J, van Gennip AH, Leen R, Meinsma R, Caron HN, van Kuilenburg AB.
    Cancer Chemother Pharmacol; 2006 Jan 19; 57(1):105-13. PubMed ID: 16133534
    [Abstract] [Full Text] [Related]

  • 19. Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
    Gourdeau H, Clarke ML, Ouellet F, Mowles D, Selner M, Richard A, Lee N, Mackey JR, Young JD, Jolivet J, Lafrenière RG, Cass CE.
    Cancer Res; 2001 Oct 01; 61(19):7217-24. PubMed ID: 11585758
    [Abstract] [Full Text] [Related]

  • 20. Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines.
    Shord SS, Patel SR.
    J Exp Clin Cancer Res; 2009 Jun 06; 28(1):76. PubMed ID: 19500405
    [Abstract] [Full Text] [Related]

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